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Leptin

Leptin is a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Gene Name: Leptin
Synonyms: LEP, Leptin, LEPD, Obese protein, Obese, mouse, homolog of, Obesity factor, OBS, OB
Target Sequences: NM_000230 NP_000221.1 P41159

Publications (5)

1
Leptin as a potential target for estrogen receptor-positive breast cancer. Yom CK, Lee KM, Han W, Kim SW, Kim HS, Moon BI, Jeong KY, Im SA, Noh DY. Journal of breast cancer. 2013 16:138-45. (WB; Human) [Full Text Article] [PubMed:23843844] [PMC:PMC3706857] Related Antibodies: LS-C25172.
2
Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Jones HN, Olbrych SK, Smith KL, Cnota JF, Habli M, Ramos-Gonzales O, Owens KJ, Hinton AC, Polzin WJ, Muglia LJ, Hinton RB. Placenta. 2015 36:1078-86. (WB; Mouse) [Full Text Article] [PubMed:26278057] Related Antibodies: LS-B1459.
3
Delta-like protein 1 in the pituitary-adipose axis in the adult male mouse. Bello AR, Puertas-Avendaño RA, González-Gómez MJ, González-Gómez M, Laborda J, Damas C, Ruiz-Hidalgo M, Diaz C. Journal of neuroendocrinology. 2017 August;29: [Full Text Article] [PubMed:28718206] [PMC:PMC6084355]
4
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Kirthana Ganeshan, Joni Nikkanen, Kevin Man, Yew Ann Leong, Yoshitaka Sogawa, J Alan Maschek, Tyler Van Ry, D Nyasha Chagwedera, James E Cox, Ajay Chawla. Cell. 2019 April;177:399-413.e12. [Full Text Article] [PubMed:30853215] [PMC:PMC6456449]
5
Effects of 3-nitrooxypropanol on rumen fermentation, lactational performance, and resumption of ovarian cyclicity in dairy cows. A Melgar, M T Harper, J Oh, F Giallongo, M E Young, T L Ott, S Duval, A N Hristov. Journal of dairy science. 2020 Jan;103:410-432. [Full Text Article] [PubMed:31733848]
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☰ Filters
Products
Antibodies (175)
Primary (175)
Leptin (175)
Human (93)
Mouse (58)
Rat (46)
Bovine (22)
Chicken (3)
Chimpanzee (6)
Cow (16)
Dog (6)
Gibbon (6)
Goat (3)
Hamster (6)
Horse (14)
Monkey (4)
Orangutan (3)
Pig (1)
Rabbit (3)
Sheep (3)
IHC (41)
IHC-P (17)
WB (139)
Flo (7)
ELISA (81)
ICC (17)
IF (13)
IP (10)
Peptide-ELISA (2)
RIA (1)
rabbit (122)
mouse (36)
goat (8)
rat (8)
sheep (1)
Product Group
IHCPlus (4)
IgG (67)
IgG1 (11)
IgG1,k (10)
IgG2a (1)
IgG2b,k (2)
monoclonal mc (44)
polyclonal pc (131)
03 (1)
10H1 (1)
13A127 (1)
3G1-1C9 (1)
3G7 (2)
4F12 (1)
4F8 (1)
5F10 (1)
9C10 (1)
AT7E10 (1)
C10 (8)
C4 (8)
LEP-02 (1)
YD-HLEP4B6 (1)
AP Conjugated (1)
APC (8)
APC Conjugated (10)
Azide-free (2)
Biotin Conjugated (22)
Cy3 Conjugated (8)
Cy7 Conjugated (8)
FITC Conjugated (15)
HRP Conjugated (14)
PE Conjugated (11)
Preservative Free (3)
Unconjugated (86)
aa22-167 (35)
aa15-141 (8)
aa29-160 (8)
aa134-166 (7)
aa8-37 (7)
N-Terminus (5)
C-Terminus (4)
aa116-167 (2)
aa22-56 (2)
aa57-92 (2)
Lys36 (1)
aa1-24 (1)
aa36-85 (1)
aa57-70 (1)
aa74-109 (1)
No (173)
Yes (2)
Leptin Antibody - Human, Kidney:Formalin-Fixed Paraffin-Embedded (FFPE)
Select
Leptin Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
500 µg/$460
Leptin Antibody - Anti-LEP / Leptin antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
Leptin Antibody - Anti-LEP / Leptin antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Leptin Antibody - Detection limit for recombinant GST tagged LEP is approximately 0.1 ng/ml as a capture antibody.
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Leptin Mouse anti-Human Monoclonal (3G1-1C9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Leptin Antibody - Western Blot (non-reducing) of Leptin antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Goat anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
Leptin Antibody - Western Blot (non-reducing) of Leptin antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Goat anti-Rat Polyclonal (Biotin) Antibody
Rat
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
Leptin Antibody - Western Blot (non-reducing) of Leptin antibody
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Leptin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
Leptin Antibody - Western Blot (non-reducing) of Leptin antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Leptin Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
Leptin Antibody - Western blot of recombinant Leptin.
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Leptin Rabbit anti-Cow Polyclonal (aa29-160) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
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Leptin Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
250 µg/$503
Leptin Antibody - LEP Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human placenta tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Leptin Rabbit anti-Human Polyclonal (aa8-37) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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Leptin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Pig, Human, Monkey
ELISA, IP, RIA, WB
Unconjugated
100 µl/$574
Leptin Antibody - ICC/IF analysis of Leptin in HeLa cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human Leptin antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
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Leptin Mouse anti-Human Monoclonal (AT7E10) Antibody
Human
ELISA, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
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Leptin Rabbit anti-Human Polyclonal (aa57-92) Antibody
Human
IF, IHC
Unconjugated
50 µl/$860
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Leptin Mouse anti-Human Monoclonal (YD-HLEP4B6) Antibody
Human
ELISA, IP, WB
Unconjugated
500 µg/$763; 1 mg/$957
Leptin Antibody - Confocal immunofluorescence of Leptin (LEP) Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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Leptin Rabbit anti-Human Polyclonal (aa134-166) Antibody
Human
IF, WB
Unconjugated
400 µl/$393
Leptin Antibody - Leptin antibody Western blot. All lanes: Anti LEP/leptin at 0.5 ug/ml. WB: NIH3T3 Whole Cell Lysate at 40 ug. Predicted band size: 16 kD. Observed band size: 16 kD.
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Leptin Rabbit anti-Mouse Polyclonal (aa74-109) Antibody
Mouse
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
Leptin Antibody - Immunohistochemistry analysis of Ob antibody in paraffin-embedded human breast carcinoma tissue.
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Leptin Rabbit anti-Human Polyclonal (aa36-85) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
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Leptin Mouse anti-Human Monoclonal (4F12) Antibody
Human
ELISA
Unconjugated
0.2 mg/$611; 0.5 mg/$845
Leptin Antibody - Western Blot; Sample: Recombinant LEP, Mouse.
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Leptin Rat anti-Mouse Monoclonal (aa22-167) (C4) Antibody
Mouse
WB
Unconjugated
100 µl/$307; 200 µl/$348; 500 µl/$486; 1 ml/$555; 2 ml/$742; 5 ml/$1,205
Select
Leptin Rabbit anti-Human Polyclonal (aa8-37) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
Select
Leptin Rabbit anti-Human Polyclonal (aa8-37) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
Select
Leptin Rabbit anti-Human Polyclonal (aa8-37) (PE) Antibody
Human
ELISA, ICC, IF, IHC-P, WB
PE Conjugated
200 µl/$952
Select
Leptin Rabbit anti-Human Polyclonal (aa8-37) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
Select
Leptin Rabbit anti-Human Polyclonal (aa8-37) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).