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HEXA

hexosaminidase A (alpha polypeptide)

HEXA is the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I).

Gene Name: hexosaminidase A (alpha polypeptide)
Synonyms: HEXA, Hexosaminidase subunit A, TSD
Target Sequences: NM_000520 NP_000511.2 P06865

Publications (1)

1
Novel bicistronic lentiviral vectors correct ß-Hexosaminidase deficiency in neural and hematopoietic stem cells and progeny: implications for in vivo and ex vivo gene therapy of GM2 gangliosidosis. Francesca Ornaghi, Davide Sala, Fabiana Tedeschi, Maria Chiara Maffia, Martina Bazzucchi, Francesco Morena, Manuela Valsecchi, Massimo Aureli, Sabata Martino, Angela Gritti. Neurobiology of disease. 2020 February;134:104667. [Full Text Article] [PubMed:31682993] Related Antibodies: LS-C197404.

☰ Filters
Antibodies (66)
ELISA Kits (10)
Proteins (10)
Custom (3)
Over-Expression Lysate (2)
Primary (66)
Recombinant (8)
Sandwich (7)
HEXA (86)
Human (61)
Mouse (32)
Rat (16)
Dog (4)
Gibbon (3)
Guinea pig (4)
Monkey (5)
Orangutan (3)
Pig (12)
IHC (15)
IHC-P (10)
WB (60)
Flo (4)
ELISA (23)
IF (2)
rabbit (59)
mouse (7)
Product Group
IHCPlus (3)
IgG (33)
IgG1,k (1)
IgG2a (1)
IgG2a,l (1)
IgG2b (3)
monoclonal mc (6)
polyclonal pc (60)
1D4B (1)
3D1 (1)
3F10 (2)
AT20F1 (1)
96-Well Microplate (1)
96-Well Strip Plate (9)
AP Conjugated (3)
APC (2)
APC Conjugated (5)
Azide-free (2)
Biotin Conjugated (7)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (7)
HRP Conjugated (7)
PE Conjugated (5)
Unconjugated (28)
aa142-170 (8)
aa315-343 (8)
aa318-529 (8)
aa319-528 (8)
aa431-480 (4)
121-170 aa, Internal (1)
Internal (1)
aa1-529 (1)
aa191-207 (1)
aa513-529 (1)
No (85)
Yes (1)
Cell Culture Supernatants (1)
Plasma (7)
Serum (7)
Tissue Homogenates (3)
GST (1)
His (3)
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His-T7 (2)
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Human (7)
Mouse (2)
293T Cells (1)
Baculovirus (2)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (3)
HEXA Antibody - Anti-HEXA antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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HEXA Rabbit anti-Human Polyclonal (aa142-170) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$440
HEXA Antibody - Anti-HEXA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HEXA Rabbit anti-Human Polyclonal (aa431-480) Antibody
Mouse, Dog, Guinea pig, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HEXA Antibody - Anti-HEXA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HEXA Rabbit anti-Human Polyclonal (aa431-480) (HRP) Antibody
Mouse, Dog, Guinea pig, Pig, Orangutan, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$459
HEXA Antibody - Anti-HEXA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HEXA Rabbit anti-Human Polyclonal (aa431-480) (Biotin) Antibody
Mouse, Dog, Guinea pig, Pig, Orangutan, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$459
HEXA Antibody - Anti-HEXA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HEXA Rabbit anti-Human Polyclonal (aa431-480) (FITC) Antibody
Mouse, Dog, Guinea pig, Pig, Orangutan, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$459
HEXA Antibody - Immunofluorescence of monoclonal antibody to HEXA on HeLa cell . [antibody concentration 10 ug/ml]
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HEXA Mouse anti-Human Monoclonal (3D1) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$413
HEXA Antibody - Anti-HEXA antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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HEXA Mouse anti-Human Monoclonal (AT20F1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$440
HEXA Protein
Select
Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$351; 250 µg/$925; 10 µg/$249
HEXA ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$752
HEXA Antibody - Western blot using HEXA monoclonal antibody against human HEXA (AA: 29-181) recombinant protein. (Expected MW is 43.1 kDa)
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HEXA Mouse anti-Human Monoclonal (3F10) Antibody
Human
ELISA, Flo, WB
Unconjugated
0.1 mg/$426
HEXA Antibody - Western blot analysis of extracts of various cell lines.
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HEXA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
HEXA Antibody - Immunohistochemistry image at a dilution of 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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HEXA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$284; 100 µg/$348
HEXA Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with HEXA Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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HEXA Rabbit anti-Human Polyclonal (aa315-343) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$376
HEXA Antibody - Immunohistochemistry of paraffin-embedded rat testis using HEXA antibody at dilution of 1:100 (40x lens).
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HEXA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
HEXA Antibody - HEXA antibody. IHC(P): Human Intestinal Cancer Tissue.
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HEXA Rabbit anti-Human Polyclonal (aa191-207) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$421
Select
HEXA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
HEXA Antibody - 1:100 staining human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HEXA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
HEXA Antibody - HEXA Antibody in Western Blot (WB)
Select
HEXA Mouse anti-Human Monoclonal (3F10) Antibody
Mouse, Human
Flo, WB
Unconjugated
100 µg/$460
Select
HEXA Mouse anti-Human Monoclonal (aa1-529) (1D4B) Antibody
Human
IHC, WB
Unconjugated
100 µg/$787
Select
HEXA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$421
Select
HEXA Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
Select
HEXA Rabbit anti-Human Polyclonal (aa315-343) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$642
Select
HEXA Rabbit anti-Human Polyclonal (aa315-343) (AP) Antibody
Human
ELISA, WB
AP Conjugated
200 µl/$825
Select
HEXA Rabbit anti-Human Polyclonal (aa142-170) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$642
HEXA Antibody - Western blot of HEXA antibody
Select
HEXA Rabbit anti-Human Polyclonal (121-170 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
Viewing 1-25 of 86 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).