Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Some HIV-1, HIV-2, and SIV isolates of different genetic subtypes and biological phenotypes use other chemokine receptors, such as CXCR6, a T-lymphocyte-expressed seven-transmembrane domain receptor that mediates fusion, entry, and trafficking of tumor-infiltrating lymphocytes.
|Gene Name:||chemokine (C-X-C motif) receptor 6|
|Family/Subfamily:||GPCR , Chemokine|
|Synonyms:||CXCR6, CD186 antigen, CXCR-6, STRL33, TYMSTR, BONZO, CD186, CDw186, CXC-R6|
|Target Sequences:||NM_006564 NP_006555.1 O00574|
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