Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
|Gene Name:||potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4|
|Family/Subfamily:||Ion Channel , Potassium channel - calcium-activated|
|Synonyms:||KCNN4, HIKCa1, HKCa4, HIK1, IK1, KCA4, HSK4, IKCA1, KCa3.1, SK4, SKCa 4, Putative Gardos channel, SKCa4|
|Target Sequences:||NM_002250 NP_002241.1 O15554|
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