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UCHL1 / PGP9.5
ubiquitin carboxyl-terminal hydrolase L1 (ubiquitin thiolesterase)
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
| Gene Name: | ubiquitin carboxyl-terminal hydrolase L1 (ubiquitin thiolesterase) |
| Family/Subfamily: | Protease , Cysteine C12 |
| Synonyms: | UCHL1, Ubiquitin C-terminal hydrolase, PARK5, PGP9.5, PGP95, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, Uch-L1, Ubiquitin carboxyl-terminal esterase L1, HEL-117, NDGOA, HEL-S-53, SPG79 |
| Target Sequences: | NM_004181 NP_004172.2 P09936 |
Publications (4)
1
Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and three-dimensional projection of the human enteric nervous system. Liu YA, Chen Y, Chiang AS, Peng SJ, Pasricha PJ, Tang SC. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2011 23:e446-57. (IHC)
[PubMed:21895876]
2
Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1. Zhang M, Deng Y, Luo Y, Zhang S, Zou H, Cai F, Wada K, Song W. Journal of neurochemistry. 2012 120:1129-38.
[PubMed:22212137]
3
The fetal ovary exhibits temporal sensitivity to a 'real-life' mixture of environmental chemicals. Lea RG, Amezaga MR, Loup B, Mandon-Pépin B, Stefansdottir A, Filis P, Kyle C, Zhang Z, Allen C, Purdie L, Jouneau L, Cotinot C, Rhind SM, Sinclair KD, Fowler PA. Scientific reports. 2016 6:22279. (WB; Human)
[Full Text Article]
[PubMed:26931299]
[PMC:PMC4773987]
Related Antibodies: LS-B489.
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UCHL1 / PGP9.5 Chicken anti-Human Polyclonal Antibody
Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
UCHL1 / PGP9.5 Goat anti-Human Polyclonal (aa58-68) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
ELISA, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
UCHL1 / PGP9.5 Rabbit anti-Human Polyclonal (aa100-200) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
UCHL1 / PGP9.5 Rabbit anti-Human Polyclonal (aa171-220) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
UCHL1 / PGP9.5 Mouse anti-Human Monoclonal (UMAB244) Antibody
Mouse, Rat, Human
IHC, PMA, WB
Unconjugated
100 µl/$493
UCHL1 / PGP9.5 Mouse anti-Human Monoclonal (Carrier-free) (UMAB244) Antibody
Mouse, Rat, Human
IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
UCHL1 / PGP9.5 Rabbit anti-Human Polyclonal (aa200-223) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
UCHL1 / PGP9.5 Mouse anti-Human Monoclonal (BH7) Antibody
Human
IF, IHC, WB
Unconjugated
100 µl/$343
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Microplate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$724
Sandwich
96-Well Microplate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$724
Sandwich CLIA
12 x 8-Well Microstrips
Human
15.63 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$808
UCHL1 / PGP9.5 Rabbit anti-Human Polyclonal (aa187-214) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Cancer Pathology
Cancer
UCHL1 / PGP9.5 Mouse anti-Human Monoclonal (1B8-4D2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$485
UCHL1 / PGP9.5 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
UCHL1 / PGP9.5 Rabbit anti-Human Polyclonal (aa16-46) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
UCHL1 / PGP9.5 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Dog, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$460
UCHL1 / PGP9.5 Mouse anti-Human Monoclonal (31A3) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.2 mg/$536
Sandwich
96-Well Strip Plate
Pig
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
UCHL1 / PGP9.5 Mouse anti-Human Monoclonal Antibody
Guinea pig, Rat, Pig, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$485
UCHL1 / PGP9.5 Rabbit anti-Human Polyclonal (aa16-46) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$737
Cancer Pathology
Cancer
UCHL1 / PGP9.5 Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
UCHL1 / PGP9.5 Mouse anti-Human Monoclonal (OTI2B5) Antibody
Rat, Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
UCHL1 / PGP9.5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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