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TTR / Transthyretin

transthyretin

TTR / Transthyretin is transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Gene Name: transthyretin
Synonyms: TTR, ATTR, CTS1, CTS, HsT2651, PALB, Prealbumin, TBPA, Transthyretin, Carpal tunnel syndrome 1, Prealbumin, amyloidosis type I, Thyroxine-binding prealbumin
Target Sequences: NM_000371 NP_000362.1 P02766

Publications (4)

1
Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer's disease. Bergen AA, Kaing S, ten Brink JB; Netherlands Brain Bank, Gorgels TG, Janssen SF. BMC genomics. 2015 16:956. (IHC; Human) [Full Text Article] [PubMed:26573292] [PMC:PMC4647590]
2
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing. Finn JD, Smith AR, Patel MC, Shaw L, Youniss MR, van Heteren J, Dirstine T, Ciullo C, Lescarbeau R, Seitzer J, Shah RR, Shah A, Ling D, Growe J, Pink M, Rohde E, Wood KM, Salomon WE, Harrington WF, Dombrowski C, Strapps WR, Chang Y, Morrissey DV. Cell reports. 2018 February;22:2227-2235. [Full Text Article] [PubMed:29490262] Related Antibodies: LS-C407961.
3
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. Michaela Auer-Grumbach, Stefan Toegel, Maria Schabhüttl, Daniela Weinmann, Catharina Chiari, David L H Bennett, Christian Beetz, Dennis Klein, Peter M Andersen, Ilka Böhme, Regina Fink-Puches, Michael Gonzalez, Matthew B Harms, William Motley, Mary M Reilly, Wilfried Renner, Sabine Rudnik-Schöneborn, Beate Schlotter-Weigel, Andreas C Themistocleous, Jochen H Weishaupt, Albert C Ludolph, Thomas Wieland, Feifei Tao, Lisa Abreu, Reinhard Windhager, Manuela Zitzelsberger, Tim M Strom, Thomas Walther. American journal of human genetics. 2016 September;99:607-623. [Full Text Article] [PubMed:27588448] [PMC:PMC5011077]
4
Rescue of retinal morphology and function in a humanized mouse at the mouse retinol-binding protein locus. Li Liu, Tomohiro Suzuki, Jingling Shen, Shigeharu Wakana, Kimi Araki, Ken-Ichi Yamamura, Lei Lei, Zhenghua Li. Laboratory investigation; a journal of technical methods and pathology. 2017 April;97:395-408. [Full Text Article] [PubMed:28134916]
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Plasma (34)
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TTR / Transthyretin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
1.56 - 100 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$863
TTR / Transthyretin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
25 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.31 - 20 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.125 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
TTR / Transthyretin ELISA Kit
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Development Kit
Antibody Pair and Standard
Pig
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,352; 1000 Wells/$2,029
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
10 - 250 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TTR / Transthyretin ELISA Kit
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Development Kit
Antibody Pair and Standard
Canine
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,356; 1000 Wells/$2,037
TTR / Transthyretin ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,182; 1000 Wells/$1,747
TTR / Transthyretin ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
TTR / Transthyretin ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
TTR / Transthyretin ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
TTR / Transthyretin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Microplate
Rat
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
TTR / Transthyretin ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$961
TTR / Transthyretin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
25 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
TTR / Transthyretin ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
8.23 - 6000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$968
TTR / Transthyretin ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
TTR / Transthyretin ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).