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APOB / Apolipoprotein B

apolipoprotein B

Apolipoprotein B (ApoB) is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL). The protein occurs in the plasma in 2 main isoforms, apoB-48 and apoB-100. The first is synthesized exclusively by the gut, the second by the liver. The intestinal (B-48) and hepatic (B-100) forms of apoB are coded by a single gene and by a single mRNA transcript larger than 16 kb. The 2 proteins share a common amino terminal sequence. In the ApoB-100 isoform the precursor has 4563 amino acids, and the mature apoB-100 has 4536 amino acid residues. Mature, circulating B-48 is homologous over its entire length (estimated to be between 2130 and 2144 amino acid residues) with the amino-terminal portion of B-100 and contains no sequence from the carboxyl end of B-100. From structural studies, it is thought that apoB-48 represents the amino-terminal 47% of apoB-100 and that the carboxyl terminus of apoB-48 is in the vicinity of residue 2151 of apoB-100. Apolipoprotein B-48 may be the product of an intestinal mRNA with an in-frame UAA stop codon resulting from a C-to-U change in the codon CAA encoding Gln(2153) in apoB-100 mRNA. Since only the sequence that codes B-100 is present in genomic DNA, this presents the possibility of an organ-specific introduction of a stop codon to an mRNA and the change from CAA to UAA of codon 2153 of the message as a unique RNA editing process.

Gene Name: apolipoprotein B
Synonyms: APOB, ApoB-100, Apolipoprotein B-48, ApoB-48, Apolipoprotein B, FLDB, LDLCQ4, Mutant Apo B 100, Apo B-100, Apolipoprotein B-100, Apolipoprotein B48
Target Sequences: NM_000384 NP_000375.2 P04114

Publications (7)

1
Apolipoprotein B48, the Structural Component of Chylomicrons, Is Sufficient to Antagonize Staphylococcus aureus Quorum-Sensing. Elmore BO, Triplett KD, Hall PR. PloS one. 2015 10:e0125027. (WB; Mouse) [Full Text Article] [PubMed:25942561] [PMC:PMC4420250] Related Antibodies: LS-B6180.
2
Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding. Zhu L, Shi J, Luu TN, Neuman JC, Trefts E, Yu S, Palmisano BT, Wasserman DH, Linton MF, Stafford JM. Molecular metabolism. 2018 February;8:106-116. [Full Text Article] [PubMed:29331506] [PMC:PMC5985047] Related Antibodies: LS-B6180.
3
Spatial distributions of lipids in atherosclerosis of human coronary arteries studied by time-of-flight secondary ion mass spectrometry. Lehti S, Sjövall P, Käkelä R, Mäyränpää MI, Kovanen PT, Öörni K. The American journal of pathology. 2015 May;185:1216-1233. [Full Text Article] [PubMed:25805604]
4
Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties. Satu Lehti, Su D Nguyen, Ilya Belevich, Helena Vihinen, Hanna M Heikkilä, Rabah Soliymani, Reijo Käkelä, Jani Saksi, Matti Jauhiainen, Gregory A Grabowski, Outi Kummu, Sohvi Hörkkö, Marc Baumann, Perttu J Lindsberg, Eija Jokitalo, Petri T Kovanen, Katariina Öörni. The American journal of pathology. 2018 Feb;188:525-538. [Full Text Article] [PubMed:29154769]
5
Estrogen-related receptor ? regulates hepatic triglyceride metabolism through phospholipase A2 G12B. Longhui Chen, Min Wu, Shengnan Zhang, Wenjuan Tan, Min Guan, Liqiang Feng, Chen Chen, Jun Tao, Ling Chen, Linbing Qu. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Jul;33:7942-7952. [Full Text Article] [PubMed:30922124]
6
Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity. Zhu L, Martinez MN, Emfinger CH, Palmisano BT, Stafford JM. American journal of physiology. Endocrinology and metabolism. 2014 May;306:E1188-97. [Full Text Article] [PubMed:24691030] [PMC:PMC4116406] Related Antibodies: LS-B6180.
7
Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance. Zhu L, Brown WC, Cai Q, Krust A, Chambon P, McGuinness OP, Stafford JM. Diabetes. 2013 Feb;62:424-34. [Full Text Article] [PubMed:22966069] [PMC:PMC3554377] Related Antibodies: LS-B6180.
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Antibodies (197)
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APOB / Apolipoprotein B (246)
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APOB / Apolipoprotein B Antibody - Anti-Apolipoprotein B antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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APOB / Apolipoprotein B Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
ID, IHC, IHC-P, WB
Unconjugated
0.05 ml/$525
APOB / Apolipoprotein B Antibody - Anti-Apolipoprotein B antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
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APOB / Apolipoprotein B Goat anti-Human Polyclonal (aa3984-3995) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
APOB / Apolipoprotein B Antibody - Anti-Apolipoprotein B antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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APOB / Apolipoprotein B Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$725
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APOB / Apolipoprotein B Goat anti-Human Polyclonal Antibody
IP, WB
Unconjugated
1 ml/$494
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APOB / Apolipoprotein B Goat anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
1 ml/$979
APOB / Apolipoprotein B Antibody - Anti-Apolipoprotein B antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOB / Apolipoprotein B Rabbit anti-Human Polyclonal (aa4031-4080) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
APOB / Apolipoprotein B ELISA Kit
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Competitive EIA
96-Well Microplate
Mouse
0.156 - 10 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$734
APOB / Apolipoprotein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$861
APOB / Apolipoprotein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$855
APOB / Apolipoprotein B ELISA Kit
Select
Sandwich
96-Well Microplate
Human
78.13 - 5000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$563
APOB / Apolipoprotein B ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
31.25 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$563
APOB / Apolipoprotein B Protein
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Human
None
550 kDa
500 µg/$417
APOB / Apolipoprotein B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$834
APOB / Apolipoprotein B Antibody - Anti-APOB / Apolipoprotein B antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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APOB / Apolipoprotein B Mouse anti-Human Monoclonal (GF1) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
0.5 mg/$505
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APOB / Apolipoprotein B Mouse anti-Human Monoclonal (2000) Antibody
Human
ELISA, IHC, IHC-Fr
Unconjugated
1 ml/$680
APOB / Apolipoprotein B Antibody - Immunofluorescence analysis of Apolipoprotein B was performed using 70% confluent log phase Hep G2 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton X-100 for 10 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Apolipoprotein B (F2C9) Mouse Monoclonal Antibody at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate a dilution of 1:2000 for 45 minutes at room temperature (Panel a: green). Nuclei (Panel b: blue) were stained with DAPI. F-actin (Panel c: red) was stained with Alexa Fluor® 555 Rhodamine Phalloidin. Panel d represents the merged image showing cytoplasmic localization. Panel e shows the no primary antibody control. The images were captured at 60X magnification.
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APOB / Apolipoprotein B Mouse anti-Human Monoclonal (F2C9) Antibody
Human
ELISA, IF, IP, RIA
Unconjugated
1 mg/$824
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APOB / Apolipoprotein B Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr
Unconjugated
1 ml/$680
APOB / Apolipoprotein B Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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APOB / Apolipoprotein B Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P
Unconjugated
0.5 mg/$460
APOB / Apolipoprotein B Antibody - Western Blot; Sample: Recombinant protein.
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APOB / Apolipoprotein B Rabbit anti-Mouse Polyclonal (aa3360-3526) Antibody
Mouse
WB
Unconjugated
100 µl/$302; 200 µl/$345; 500 µl/$489; 1 ml/$561
APOB / Apolipoprotein B Antibody - Immunofluorescence of HepG2 cells using ApoB mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
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APOB / Apolipoprotein B Mouse anti-Human Monoclonal (6G6) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$426
APOB / Apolipoprotein B ELISA Kit
Select
Sandwich
96-Well Microplate
Human
2.458 - 600 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
APOB / Apolipoprotein B Protein - Recombinant Apolipoprotein B By SDS-PAGE
Select
E. coli
6His, N-terminus
21.4 kDa
10 µg/$241; 50 µg/$301; 100 µg/$384; 200 µg/$479; 1 mg/$1,250; 500 µg/$955; 5 mg/$2,493
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APOB / Apolipoprotein B Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$430
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APOB / Apolipoprotein B Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr
Unconjugated
1 ml/$680
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APOB / Apolipoprotein B Mouse anti-Human Monoclonal (Concentrated) (4C11) Antibody
Human
ELISA, IHC, IHC-Fr
Unconjugated, Concentrated
1 ml/$457
Viewing 1-25 of 246 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).