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APOA1 / Apolipoprotein A 1

apolipoprotein A-I

APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18-amino acid signal peptide is removed co-translationally and a 6-amino acid propeptide is cleaved post-translationally. Variation in the latter step, in addition to modifications leading to so-called isoforms, is responsible for some of the polymorphism observed. APOA1 is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the C-III gene is transcribed convergently in relation to A-I. Defects in the apolipoprotein A-1 gene are associated with HDL deficiency and Tangier disease.

Gene Name: apolipoprotein A-I
Synonyms: APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI
Target Sequences: NM_000039 NP_000030.1 P02647

Publications (6)

1
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC. Journal of lipid research. 2006 47:832-43. [PubMed:16418537]
2
A microbial TLR2 agonist imparts macrophage-activating ability to apolipoprotein A-1. Hasebe A, Pennock ND, Mu HH, Chan FV, Taylor ML, Cole BC. Journal of immunology (Baltimore, Md. : 1950). 2006 177:4826-32. [PubMed:16982924]
3
Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression. Molina L, Fasquelle L, Nouvian R, Salvetat N, Scott HS, Guipponi M, Molina F, Puel JL, Delprat B. Human molecular genetics. 2013 22:1289-99. (ICC, IHC; Mouse) [PubMed:23255163]
4
Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial. Graham SM, Chen J, Chung DW, Barker KR, Conroy AL, Hawkes MT, Namasopo S, Kain KC, López JA, Liles WC. Malaria journal. 2016 15:56. (ELISA; Human) [Full Text Article] [PubMed:26830467] [PMC:PMC4736470] Related Antibodies: LS-C11247, LS-C11248.
5
Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men. Graham SM, Chen J, Le J, Ling M, Chung DW, Liles WC, López JA. International journal of medical sciences. 2019 January;16:276-284. [Full Text Article] [PubMed:30745808] [PMC:PMC6367531] Related Antibodies: LS-C11247.
6
Apolipoprotein CIII Deficiency Protects Against Atherosclerosis in Knockout Rabbits. Haizhao Yan , Manabu Niimi , Fumikazu Matsuhisa , Huanjin Zhou, Shuji Kitajima, Yajie Chen, Chuan Wang, Xiawen Yang, Jian Yao, Dongshan Yang, Jifeng Zhang, Masami Murakami, Katsuyuki Nakajima, Yao Wang, Enqi Liu, Jingyan Liang, Y Eugene Chen, Jianglin Fan. Arteriosclerosis, thrombosis, and vascular biology. 2020 September;40:2095-2107. [Full Text Article] [PubMed:32757647] Related Antibodies: LS-C314186.
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Proteins (33)
Native (2)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (27)
APOA1 / Apolipoprotein A 1 (33)
Bind (1)
ELISA (1)
Func (1)
SDS-PAGE (3)
No (33)
6His, C-terminus (3)
6His, N-terminus (3)
8His, N-terminus (1)
Fc (1)
Fc, C-terminus (1)
GST (1)
His (5)
His, N-Terminal (1)
His,C-terminus (4)
His,N-terminus (1)
His-GST (1)
His-T7 (1)
Human IgG1 Fc, N-terminus (1)
Myc-DDK (Flag) (3)
Bovine (1)
Dog (1)
Goat (1)
Human (22)
Mouse (5)
Pig (1)
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293T Cells (1)
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E. coli (15)
HEK 293 Cells (10)
Human (1)
Human Cells (2)
Mammalian Cells (1)
Wheat Germ Extract (1)
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Purified (8)
Low endotoxin level (14)
Biologically active (1)
APOA1 / Apolipoprotein A 1 Protein
Select
Yeast
6His, N-terminus
29.5 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
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Human
None
28 kDa
0.5 mg/$401
APOA1 / Apolipoprotein A 1 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
E. coli
None
Less than 0.1 ng/µg of protein (less than 1EU/µg).
28.2 kDa
20 µg/$268; 100 µg/$349
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30.2 kDa
100 µg/$926
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E. coli
His,N-terminus
SDS-PAGE
The recombinant human APOA1 consists of 263 amino acids and predicts a molecular mass of 30.7 kDa. It migrates as an approximately 27-31 kDa band in SDS-PAGE under reducing conditions.
100 µg/$480; 1 mg/$2,339
APOA1 / Apolipoprotein A 1 Protein
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HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human APOA1/Fc is a disulfide-linked homodimeric protein.The reduced monomer consists of 481 amino acids migrates as approximately 55 kDa band in SDS-PAGE under reducing conditions as predicted.
100 µg/$480; 1 mg/$2,339
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Dog
None
29.0 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,441
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HEK 293 Cells
6His, N-terminus
29.6 kDa
200 µl/$283
Select
HEK 293 Cells
8His, N-terminus
29.6 kDa
100 µg/$298
APOA1 / Apolipoprotein A 1 Protein - 12.5% SDS-PAGE of human APOA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
55.11 kDa
10 µg/$479; 25 µg/$670
APOA1 / Apolipoprotein A 1 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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HEK 293 Cells
6His, N-terminus
27 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432; 250 µg/$726; 500 µg/$1,270; 1000 µg/$1,799
APOA1 / Apolipoprotein A 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
30.78 kDa
20 µg/$150
APOA1 / Apolipoprotein A 1 Protein
Select
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse ApoA1 comprises 257 amino acids and has a predicted molecular mass of 30.2 kDa. The apparent molecular mass of the protein is approximately 27-31 kDa in SDS-PAGE under reducing conditions due to glycosylation.
100 µg/$480
APOA1 / Apolipoprotein A 1 Protein - Purified recombinant protein APOA1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
28.9 kDa
20 µg/$1,107
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
55.8 kDa
100 µg/$926
APOA1 / Apolipoprotein A 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
30.78 kDa
100 µg/$494
APOA1 / Apolipoprotein A 1 Protein - Recombinant Apolipoprotein A1 By SDS-PAGE
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E. coli
His, N-Terminal
18.5 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
Select
E. coli
115 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
12.76 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30.2 kDa
10 µg/$248; 50 µg/$288
Select
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
55 kDa
100 µg/$926; 1 mg/$4,191
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30 kDa
10 µg/$288; 50 µg/$436
APOA1 / Apolipoprotein A 1 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
HEK 293 Cells
Human IgG1 Fc, N-terminus
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$519
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
29.0 kDa
10 µg/$288; 50 µg/$436
Viewing 1-25 of 33 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).