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APOA1 / Apolipoprotein A 1

apolipoprotein A-I

APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18-amino acid signal peptide is removed co-translationally and a 6-amino acid propeptide is cleaved post-translationally. Variation in the latter step, in addition to modifications leading to so-called isoforms, is responsible for some of the polymorphism observed. APOA1 is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the C-III gene is transcribed convergently in relation to A-I. Defects in the apolipoprotein A-1 gene are associated with HDL deficiency and Tangier disease.

Gene Name: apolipoprotein A-I
Synonyms: APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI
Target Sequences: NM_000039 NP_000030.1 P02647

Publications (6)

1
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC. Journal of lipid research. 2006 47:832-43. [PubMed:16418537]
2
A microbial TLR2 agonist imparts macrophage-activating ability to apolipoprotein A-1. Hasebe A, Pennock ND, Mu HH, Chan FV, Taylor ML, Cole BC. Journal of immunology (Baltimore, Md. : 1950). 2006 177:4826-32. [PubMed:16982924]
3
Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression. Molina L, Fasquelle L, Nouvian R, Salvetat N, Scott HS, Guipponi M, Molina F, Puel JL, Delprat B. Human molecular genetics. 2013 22:1289-99. (ICC, IHC; Mouse) [PubMed:23255163]
4
Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial. Graham SM, Chen J, Chung DW, Barker KR, Conroy AL, Hawkes MT, Namasopo S, Kain KC, López JA, Liles WC. Malaria journal. 2016 15:56. (ELISA; Human) [Full Text Article] [PubMed:26830467] [PMC:PMC4736470] Related Antibodies: LS-C11247, LS-C11248.
5
Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men. Graham SM, Chen J, Le J, Ling M, Chung DW, Liles WC, López JA. International journal of medical sciences. 2019 January;16:276-284. [Full Text Article] [PubMed:30745808] [PMC:PMC6367531] Related Antibodies: LS-C11247.
6
Apolipoprotein CIII Deficiency Protects Against Atherosclerosis in Knockout Rabbits. Haizhao Yan , Manabu Niimi , Fumikazu Matsuhisa , Huanjin Zhou, Shuji Kitajima, Yajie Chen, Chuan Wang, Xiawen Yang, Jian Yao, Dongshan Yang, Jifeng Zhang, Masami Murakami, Katsuyuki Nakajima, Yao Wang, Enqi Liu, Jingyan Liang, Y Eugene Chen, Jianglin Fan. Arteriosclerosis, thrombosis, and vascular biology. 2020 September;40:2095-2107. [Full Text Article] [PubMed:32757647] Related Antibodies: LS-C314186.
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APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
1.406 - 90 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich
96-Well Microplate
Human
1.4 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$830
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Sandwich
96-Well Strip Plate
Rat
0.21 - 150 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$741
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Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$705
APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
31.25 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich
96-Well Microplate
Human
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Mouse
0.14 - 100 ng/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$990
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Sandwich
96-Well Strip Plate
Rhesus monkey
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$940
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Sandwich
96-Well Strip Plate
Rabbit
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$818
APOA1 / Apolipoprotein A 1 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Bovine
78 - 5000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
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Competitive EIA
96-Well Strip Plate
Dog
28.12 - 1800 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$854
APOA1 / Apolipoprotein A 1 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rabbit
24.69 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$741
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$795
APOA1 / Apolipoprotein A 1 ELISA Kit
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Competitive EIA
12 x 8-Well Microstrips
Pig
80 - 2000 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
62.5 - 4000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$627
APOA1 / Apolipoprotein A 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
APOA1 / Apolipoprotein A 1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
12.5 - 800 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,089; 1000 Wells/$1,589
APOA1 / Apolipoprotein A 1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Mouse
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,109; 1000 Wells/$1,625
APOA1 / Apolipoprotein A 1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Rat
0.42 - 300 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,153; 1000 Wells/$1,698
APOA1 / Apolipoprotein A 1 ELISA Kit
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Development Kit
Antibody Pair and Standard
Rabbit
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
500 Wells/$1,254; 1000 Wells/$1,867
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96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$626
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Custom
96-Well Strip Plate
Monkey
0.7 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$1,100
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).