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CD36

CD36 molecule (thrombospondin receptor)

Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Gene Name: CD36 molecule (thrombospondin receptor)
Synonyms: CD36, Cluster determinant 36, FAT, Fatty acid translocase, Glycoprotein IIIb, gp4, GPIIIB, GPIV, PAS-4 protein, PAS IV, PASIV, Platelet collagen receptor, Platelet glycoprotein IV, SCARB3, Thrombospondin receptor, BDPLT10, CD36 antigen, CHDS7, gp3B, PAS-4, Platelet glycoprotein 4
Target Sequences: NM_000072 NP_000063.2 P16671

Publications (23)

1
Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. Febbraio M, Podrez EA, Smith JD, Hajjar DP, Hazen SL, Hoff HF, Sharma K, Silverstein RL. The Journal of clinical investigation. 2000 105:1049-56. [PubMed:10772649] [PMC:PMC300837]
2
Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Circulation research. 2005 97:372-9. (IHC, WB; Mouse) [PubMed:16051889]
3
Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady-state CD8 alpha+ dendritic cells. Tagliani E, Guermonprez P, Seplveda J, Lpez-Bravo M, Ardavn C, Amigorena S, Benvenuti F, Burrone OR. Journal of immunology (Baltimore, Md. : 1950). 2008 180:3201-9. (WB; Mouse) [PubMed:18292544]
4
Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanism. During A, Doraiswamy S, Harrison EH. Journal of lipid research. 2008 49:1715-24. [PubMed:18424859] [PMC:PMC2444002]
5
IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle. Chabowski A, Zmijewska M, Gorski J, Bonen A, Kaminski K, Kozuch M, Winnicka MM. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2008 105-17. (WB; Mouse) [PubMed:19258660]
6
Scavenger receptors are associated with cellular interactions of S100A12 in vitro and in vivo. Hoppmann S, Steinbach J, Pietzsch J. The international journal of biochemistry & cell biology. 2010 42:651-61. [PubMed:20025991]
7
A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W. Gastroenterology. 2010 139:653-63. [PubMed:20303349] [PMC:PMC2910786]
8
Oxidant production, oxLDL uptake, and CD36 levels in human monocytederived macrophages are downregulated by the macrophage-generated antioxidant 7,8-dihydroneopterin. Gieseg SP, Amit Z, Yang YT, Shchepetkina A, Katouah H. Antioxidants & redox signaling. 2010 13:1525-34. [PubMed:20408759]
9
Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats. Marecki JC, Ronis MJ, Shankar K, Badger TM. The Journal of nutritional biochemistry. 2011 22:142-52. [PubMed:20435456]
10
Modulation of macrophage fatty acid content and composition by exposure to dyslipidemic serum in vitro. Wong BX, Kyle RA, Croft KD, Quinn CM, Jessup W, Yeap BB. Lipids. 2011 46:371-80. [PubMed:21286835]
11
Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. Sos BC, Harris C, Nordstrom SM, Tran JL, Balzs M, Caplazi P, Febbraio M, Applegate MA, Wagner KU, Weiss EJ. The Journal of clinical investigation. 2011 121:1412-23. (WB; Mouse) [PubMed:21364286] [PMC:PMC3069761]
12
Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. Faustino JV, Wang X, Johnson CE, Klibanov A, Derugin N, Wendland MF, Vexler ZS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:12992-3001. [PubMed:21900578] [PMC:PMC3539822]
13
CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein. Huang W, Febbraio M, Silverstein RL. PloS one. 2011 6:e29092. [PubMed:22216174] [PMC:PMC3244426]
14
CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies. Baines RJ, Chana RS, Hall M, Febbraio M, Kennedy D, Brunskill NJ. American journal of physiology. Renal physiology. 2012 303:F1006-14. (IHC, WB; Mouse) [PubMed:22791331]
15
Stored platelets alter glycerophospholipid and sphingolipid species, which are differentially transferred to newly released extracellular vesicles. Pienimaeki-Roemer A, Ruebsaamen K, Boettcher A, Ors E, Scherer M, Liebisch G, Kilalic D, Ahrens N, Schmitz G. Transfusion. 2013 53:612-26. (WB; Human) [PubMed:22804622]
16
C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle. Olson AK, Ledee D, Iwamoto K, Kajimoto M, O'Kelly Priddy C, Isern N, Portman MA. Journal of molecular and cellular cardiology. 2013 55:156-64. (WB; Mouse) [PubMed:22828478] [PMC:PMC3524362]
17
Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia. Nair KS, Bigelow ML, Asmann YW, Chow LS, Coenen-Schimke JM, Klaus KA, Guo ZK, Sreekumar R, Irving BA. Oncoimmunology. 2012 1:618-629. (WB; Mouse) [PubMed:22934254] [PMC:PMC3429566]
18
Enhanced recovery from ischemia-reperfusion injury in PI3K dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling. McLean BA, Kienesberger PC, Wang W, Masson G, Zhabyeyev P, Dyck JR, Oudit GY. Journal of molecular and cellular cardiology. 2013 54:18-Sep. (WB; Mouse) [PubMed:23142539]
19
Resistin-like molecule ß is abundantly expressed in foam cells and is involved in atherosclerosis development. Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T. Arteriosclerosis, thrombosis, and vascular biology. 2013 33:1986-93. (WB, IF; Mouse) [Full Text Article] [PubMed:23702657] Related Antibodies: LS-B662.
20
The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis. Masakazu Hanayama, Yasunori Yamamoto, Hiroki Utsunomiya, Osamu Yoshida, Shuang Liu, Masaki Mogi, Bunzo Matsuura, Eiji Takeshita, Yoshiou Ikeda, Yoichi Hiasa. Scientific reports. 2021 June;11:13380. [Full Text Article] [PubMed:34183709] [PMC:PMC8239050] Related Antibodies: LS-B662.
21
Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation. Khoa D Nguyen, Claudia Macaubas, Phi Truong, Nan Wang, Tieying Hou, Taejin Yoon, Elizabeth D Mellins. Molecular immunology. 2014 June;59:172-9. [Full Text Article] [PubMed:24632292] [PMC:PMC4068397] Related Antibodies: LS-C88455.
22
Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development. Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T. Arteriosclerosis, thrombosis, and vascular biology. 2012 32:291-8. [PubMed:22095983] Related Antibodies: LS-B662.
23
Redistribution and hemostatic action of recombinant activated factor VII associated with platelets. Lopez-Vilchez I, Hedner U, Altisent C, Diaz-Ricart M, Escolar G, Galan AM. The American journal of pathology. 2011 Jun;178:2938-48. [Full Text Article] [PubMed:21641410] [PMC:PMC3124331] Related Antibodies: LS-C88455.
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CD36 Antibody - Anti-CD36 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD36 Rabbit anti-Human Polyclonal (aa300-400) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
CD36 Antibody - Anti-CD36 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD36 Rabbit anti-Human Polyclonal (aa300-400) (Biotin) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$406
CD36 Antibody - Anti-CD36 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD36 Rabbit anti-Human Polyclonal (aa300-400) (DY488) Antibody
Human
ICC, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$406
CD36 Antibody - Frozen human tonsil section stained with UltraVision LP and AEC chromogen. Note staining of monocytes, macrophages and endothelial cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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CD36 Mouse anti-Human Monoclonal (185-1G2) Antibody
Human
Block, Flo, IF, IHC, IHC-Fr
Unconjugated
500 µl/$557
CD36 Antibody - Anti-CD36 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody at a dilution of 1:20.
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CD36 Rabbit anti-Human Polyclonal (aa99-114) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
1 Each/$485
CD36 Antibody - Anti-CD36 antibody IHC of human skeletal muscle, adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD36 Rabbit anti-Human Polyclonal (aa100-200) Antibody
Mouse, Bovine, Rat, Pig, Primate, Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
CD36 Antibody - Staining of CD36 in mouse liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD36 Mouse anti-Mouse Monoclonal (D-2712) Antibody
Mouse, Rat
IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$376
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CD36 Mouse anti-Mouse Monoclonal (JC63.1) Antibody
Mouse, Rat, Human
Flo, Func
Unconjugated
100 µg/$395
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CD36 Mouse anti-Human Monoclonal (FITC) (CLB-IVC7) Antibody
Human
Flo, IF
FITC Conjugated
100 Tests/$593
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CD36 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo, IP
Biotin Conjugated
100 µg/$533
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CD36 Mouse anti-Human Monoclonal (FA6-152) Antibody
Human
Flo, Func, IF, IHC, IHC-Fr, IP
Unconjugated
100 µg/$501
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CD36 Mouse anti-Human Monoclonal (FITC) (FA6-152) Antibody
Human
Flo, Func, IF, IHC, IHC-Fr, IP
FITC Conjugated
100 µg/$556
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CD36 Rat anti-Mouse Monoclonal Antibody
Mouse
Flo, IF
Unconjugated
100 µg/$547; 250 µg/$742
CD36 Antibody - Immunofluorescent staining of HeLa cells using anti-CD36 mouse monoclonal antibody.
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CD36 Mouse anti-Human Monoclonal (OTI1B3) Antibody
Human
IF, WB
Unconjugated
100 µl/$409
CD36 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$574
CD36 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$696
CD36 Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma with CD36 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CD36 Rabbit anti-Human Polyclonal (aa213-242) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$376
CD36 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
CD36 Antibody - Flow cytometry of mouse peripheral blood platelets with Rat anti-Mouse CD36.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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CD36 Rat anti-Mouse Monoclonal (MF3) Antibody
Mouse
Flo, IF, WB
Unconjugated
0.1 mg/$363; 0.25 mg/$444
CD36 Antibody - CD36 antibody CD36(CD36 molecule (thrombospondin receptor)) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD36 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Goat, Dog, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$414
CD36 Antibody - Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-CD36 mouse monoclonal antibody. (Dilution 1:50).
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CD36 Mouse anti-Human Monoclonal (OTI3F4) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
CD36 Antibody - CD36 antibody Western blot of Fetal Liver lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD36 Rabbit anti-Human Polyclonal (aa36-85) Antibody
Dog, Pig, Horse, Human
WB
Unconjugated
100 µl/$414
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CD36 Mouse anti-Human Monoclonal (185-1G2) Antibody
Human
Flo, ICC, IHC, IHC-Fr
Unconjugated
0.1 mg/$437
CD36 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:200.
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Cancer Pathology
Cancer
CD36 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
CD36 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
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CD36 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Viewing 1-25 of 225 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).