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SDF1 / CXCL12

chemokine (C-X-C motif) ligand 12

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Gene Name: chemokine (C-X-C motif) ligand 12
Family/Subfamily: Intercrine , Intercrine alpha
Synonyms: CXCL12, C-X-C motif chemokine 12, HIRH, IRH, SDF-1, SDF-1b, SDF1A, SDF1B, TPAR1, TLSF-a, TLSF-b, SDF-1a, SDF1, Sdf1alpha, Stromal cell-derived factor 1, TLSF, HSDF-1, PBSF, SCYB12
Target Sequences: NM_000609 NP_000600.1 P48061

Publications (2)

1
Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage. Jong-Ik Heo, Kwang Il Kim, Sang-Keun Woo, Joong Sun Kim, Kyu Jin Choi, Hae-June Lee, Kwang Seok Kim. Cells. 2019 October;8: [Full Text Article] [PubMed:31658727] [PMC:PMC6830118]
2
Characterization and Validation of Antibodies for Immunohistochemical Staining of the Chemokine CXCL12. Simon P Fricker, Kam Sprott, Melanie Spyra, Philipp Uhlig, Nicole Lange, Kerstin David, Yan Wang. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2019 Apr;67:257-266. [Full Text Article] [PubMed:30562126] [PMC:PMC6437344] Related Antibodies: LS-B943.

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Antibodies (110)
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SDF1 / CXCL12 (205)
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SDF1 / CXCL12 Antibody - Anti-CXCL12 antibody IHC of human breast, fibroblasts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SDF1 / CXCL12 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Xenopus, Chicken, Mouse, Dog, Guinea pig, Bat, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SDF1 / CXCL12 Antibody - Anti-CXCL12 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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SDF1 / CXCL12 Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
SDF1 / CXCL12 Antibody - Anti-CXCL12 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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SDF1 / CXCL12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
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SDF1 / CXCL12 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
IHC, IP, WB
Unconjugated
30 µg/$281; 100 µg/$484
SDF1 / CXCL12 Antibody - Western blot of SDF-1 antibody
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SDF1 / CXCL12 Rabbit anti-Human Polyclonal (C-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
SDF1 / CXCL12 Antibody - Detection limit for recombinant GST tagged CXCL12 is approximately 1 ng/ml as a capture antibody.
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SDF1 / CXCL12 Mouse anti-Human Monoclonal (1E5) Antibody
Human
ELISA
Unconjugated
100 µg/$413
SDF1 / CXCL12 Antibody - CXCL12 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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SDF1 / CXCL12 Rabbit anti-Human Polyclonal (aa64-92) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$376
SDF1 / CXCL12 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.15 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$653
SDF1 / CXCL12 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$809
SDF1 / CXCL12 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$559
SDF1 / CXCL12 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$772
SDF1 / CXCL12 ELISA Kit
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Sandwich
96-Well Microplate
Human
32.77 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$537
SDF1 / CXCL12 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$859
SDF1 / CXCL12 ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
SDF1 / CXCL12 Antibody - Anti-Murine SDF-1a (CXCL12) Western Blot Reduced
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SDF1 / CXCL12 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
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SDF1 / CXCL12 Goat anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
25 µg/$325; 50 µg/$361
SDF1 / CXCL12 ELISA Kit
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Development Kit
200 Wells
Human
63 - 4000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$180
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CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
8 kDa (SDS-PAGE)
5 µg/$284; 25 µg/$373
SDF1 / CXCL12 Antibody - Western Blot (non-reducing) of SDF-1 / CXCL12 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SDF1 / CXCL12 Goat anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
SDF1 / CXCL12 Antibody - Western Blot (non-reducing) of SDF-1 / CXCL12 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SDF1 / CXCL12 Goat anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$325; 50 µg/$361
SDF1 / CXCL12 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma
1 Plate/$537
SDF1 / CXCL12 Antibody - IHC analysis of CXCL12 using anti-CXCL12 antibody. CXCL12 was detected in paraffin-embedded section of rat spleen tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-CXCL12 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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SDF1 / CXCL12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
100 µg/$421
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SDF1 / CXCL12 Rabbit anti-Human Polyclonal (AP) Antibody
Human
ELISA, Neut, WB
AP Conjugated
50 µg/$450
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SDF1 / CXCL12 Goat anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$863
SDF1 / CXCL12 Antibody - Western blot of recombinant SDF-1 / CXCL12.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SDF1 / CXCL12 Rabbit anti-Mouse Polyclonal (aa22-89) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$299; 200 µl/$343; 500 µl/$486; 1 ml/$557
Viewing 1-25 of 205 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).