Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

STK11 / LKB1

serine/threonine kinase 11

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro).

Gene Name: serine/threonine kinase 11
Family/Subfamily: Protein Kinase , CAMKL
Synonyms: STK11, HLKB1, Peutz-Jeghers syndrome, PJS, Serine/threonine kinase 11, Liver kinase B1, LKB1
Target Sequences: NM_000455 NP_000446.1 Q15831

Publications (1)

1
miR-424 Promotes Bovine Adipogenesis Through an Unconventional Post-Transcriptional Regulation of STK11. Li Wang, Song Zhang, Wenzhen Zhang, Gong Cheng, Rajwali Khan, Zainaguli Junjvlieke, Shijun Li, Linsen Zan. Frontiers in genetics. 2020 Mar;11:145. [Full Text Article] [PubMed:32194625] [PMC:PMC7064614] Related Antibodies: LS-C388827.

☰ Filters
Antibodies (123)
cDNAs (30)
ELISA Kits (9)
Proteins (8)
cDNA Clone (2)
Cell-Based (1)
Cell-Based Phosphorylation (2)
Custom (3)
Expression-Ready ORF Clone (28)
Over-Expression Lysate (2)
Primary (123)
Recombinant (6)
Sandwich (3)
STK11 / LKB1 (170)
Human (109)
Mouse (91)
Rat (33)
Bat (4)
Bovine (5)
Chicken (7)
Chimpanzee (3)
Dog (9)
Gibbon (3)
Guinea pig (5)
Hamster (9)
Horse (9)
Monkey (16)
Non-Human Primate (1)
Pig (5)
Sheep (1)
Xenopus (4)
Zebrafish (9)
IHC (41)
IHC-P (15)
WB (108)
Flo (5)
DB (6)
ELISA (51)
ICC (10)
IF (17)
IP (3)
Peptide-ELISA (7)
rabbit (105)
mouse (18)
Product Group
IHCPlus (2)
PathPlus Cancer (2)
Ig (3)
IgG (76)
IgG1 (10)
IgG1,k (1)
monoclonal mc (19)
polyclonal pc (104)
27D10 (1)
2A7-H2 (1)
4H12 (2)
OTI0A3 (2)
OTI1F10 (2)
OTI4B2 (2)
96-Well Microplate (3)
96-Well Strip Plate (6)
AP Conjugated (5)
APC (1)
APC Conjugated (6)
Azide-free (3)
Biotin Conjugated (8)
Carrier-free (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (6)
Sepharose Conjugated (1)
Unconjugated (79)
pSer428 (11)
C-Terminus (8)
aa19-48 (8)
aa393-420 (8)
aa49-309 (8)
pSer307 (7)
pThr189 (7)
aa1-236 (6)
pSer334 (5)
aa317-366 (4)
aa71-120 (4)
aa421-433 (3)
130-210 aa (2)
270-350 aa (2)
370-450 aa (2)
Internal (2)
Ab-428 (1)
Arg425 (1)
Ser428 (1)
aa1-433 (1)
aa140-189 (1)
aa155-204 (1)
aa300-349 (1)
aa384-433 (1)
aa62-430 (1)
p189 (1)
p334 (1)
No (169)
Yes (1)
Adherent Cell Cultures (3)
Cell Lysates (1)
Plasma (2)
Serum (2)
Tissue Homogenates (2)
DDK (Flag), C-terminus (2)
DDK (Flag), N-terminus (2)
GFP, C-terminus (4)
GFP, N-terminus (2)
GST (1)
GST, N-terminus (1)
GST, N-terminus + His, C-terminus (1)
HA, C-terminus (2)
HA, N-terminus (2)
His (1)
His, C-terminus (2)
His, N-terminus (2)
His-SUMO (1)
His-T7 (1)
Myc, C-terminus (2)
Myc, N-terminus (2)
Myc-DDK (Flag) (2)
OFP, C-terminus (2)
OFP, N-terminus (2)
Untagged (4)
Human (15)
Mouse (15)
Lentiviral (2)
Mammalian (26)
Human (6)
Mouse (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (3)
Low endotoxin level (1)
STK11 / LKB1 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
STK11 / LKB1 Rabbit anti-Human Monoclonal (27D10) Antibody
Rat, Human, Monkey
IHC-P, IP, WB
Unconjugated
50 µl/$695
STK11 / LKB1 Antibody - Anti-STK11 / LKB1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$555
STK11 / LKB1 Antibody - IHC-P: LKB1 antibody testing of human liver cancer tissue
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (aa421-433) Antibody
Mouse, Dog, Guinea pig, Sheep, Bovine, Pig, Horse, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$480
STK11 / LKB1 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using LKB1 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (aa384-433) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$306; 100 µl/$366
STK11 / LKB1 Protein
Select
E. coli
His-SUMO
Less than 1.0 EU/µg protein (determined by LAL method).
64.1 kD
1 mg/$1,152; 100 µg/$400; 20 µg/$307
STK11 / LKB1 Antibody - IHC of paraffin-embedded Carcinoma of Human kidney tissue using anti-STK11 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Select
STK11 / LKB1 Mouse anti-Human Monoclonal (aa1-236) (OTI0A3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$409
STK11 / LKB1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
STK11 / LKB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, WB
Unconjugated
50 µl/$440
STK11 / LKB1 Antibody - Western blot of LKB1 antibody
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (130-210 aa) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
STK11 / LKB1 Antibody - Immunohistochemical analysis of LKB1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$289
STK11 / LKB1 Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using LKB1 (Phospho-Ser428) Antibody. The picture on the right is blocked with the phospho peptide.
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (pSer428) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (370-450 aa) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
STK11 / LKB1 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$721
STK11 / LKB1 Antibody - Western blot using STK11 mouse monoclonal antibody against NIH/3T3 (1),Raw246.7 (2), COS7 (3), Jurkat (4), HEK293 (5) and A431 (6) cell lysate.
Select
STK11 / LKB1 Mouse anti-Human Monoclonal (4H12) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$394
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (aa421-433) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$331
STK11 / LKB1 Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (pSer428) Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
STK11 / LKB1 Antibody - Immunohistochemical of paraffin-embedded M.skeletal muscle section using Mouse Stk11 Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
Select
STK11 / LKB1 Rabbit anti-Mouse Polyclonal (aa393-420) Antibody
Mouse
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$381
STK11 / LKB1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY STK11 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-STK11.
Select
STK11 / LKB1 Mouse anti-Human Monoclonal (aa1-236) (OTI1F10) Antibody
Human
WB
Unconjugated
100 µl/$409
STK11 / LKB1 Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
STK11 / LKB1 Antibody - STK11 / LKB1 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (aa317-366) Antibody
Zebrafish, Pig, Horse, Rat, Hamster, Mouse, Dog, Bovine, Human, Monkey
WB
Unconjugated
100 µl/$434
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$347
STK11 / LKB1 Antibody - Western blot of LKB1 phosphorylation expression in PMA treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (pSer428) Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$347
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (pSer428) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$347
STK11 / LKB1 Antibody - Western blot of LKB1 antibody
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (370-450 aa) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
STK11 / LKB1 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal (270-350 aa) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Select
STK11 / LKB1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$411
Viewing 1-25 of 170 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).