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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
Protein Family And Group
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RPA3

replication protein A3, 14kDa

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER), probably through interaction with UNG (PubMed:9765279). Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA (PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (PubMed:19996105).

Gene Name: replication protein A3, 14kDa
Synonyms: RPA3, REPA3, Replication factor A protein 3, Replication protein A3 (14kD), Replication protein A3, 14kDa, RF-A protein 3, RP-A p14, RPA14
Target Sequences: NM_002947 NP_002938.1 P35244


☰ Filters
RPA3 (23)
Product Group
No (23)
RPA3 Antibody - Anti-RPA3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 111] (IgG1) to Human RPA3
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50µl   1mg/ml   $425.00
RPA3 Antibody - Western blot analysis of extracts of various cells.
Select
Rabbit Polyclonal (IgG) to Human RPA3
Mouse, Rat, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $255.00; 100µl   5.5mg/ml   $315.00; 200µl   $425.00
Select
Mouse Monoclonal [clone 14.2] (IgG1) to Human RPA3
Mouse, Human
IP, WB
Unconjugated
100µl   1mg/ml   $355.00
RPA3 Antibody - Western blot All lanes: Replication protein A 14 kDa subunit antibody at 2µg/ml Lane 1: LO2 whole cell lysate Lane 2: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 14 kDa Observed band size: 14 kDa
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
ELISA, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
ELISA, IHC, WB
HRP Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
ELISA, IHC, WB
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
ELISA, IHC, WB
FITC Conjugated
50µg   $285.00; 100µg   $385.00
RPA3 Antibody - RPA3 monoclonal antibody (M01), clone 1F4 Western blot of RPA3 expression in HL-60.
Select
Mouse Monoclonal [clone 1F4] (IgG1,l) to Human RPA3
Human
ELISA, RNAi, WB
Unconjugated
100µg   $365.00
RPA3 Antibody - IHC of paraffin-embedded lung CA patient tumor using RPA3 subunit antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $355.00
Select
Rabbit Polyclonal to Human RPA3
Human
IHC, WB
Unconjugated
100µl   $385.00
RPA3 Antibody - Immunofluorescence analysis of MCF7 cells using RPA3 antibody.
Select
Rabbit Polyclonal (IgG) to Human RPA3
Mouse, Rat, Human
IF, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $295.00; 200µl   $385.00
RPA3 Antibody - Immunochemical staining of human RPA3 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
IHC-P, WB
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
Select
Rabbit Polyclonal (IgG) to Human RPA3
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal to Human RPA3
Mouse, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
RPA3 Antibody - Immunohistochemistry of paraffin-embedded human prostate tissue using RPA3 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
ELISA, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
ELISA, WB
HRP Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
ELISA, WB
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
ELISA, WB
FITC Conjugated
50µg   $285.00; 100µg   $385.00
RPA3 Antibody - Western blot analysis of SW480, MCF7 lysate, antibody was diluted at 2000. Secondary antibody was diluted at 1:20000.
Select
Rabbit Polyclonal (IgG) to Human RPA3
Mouse, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Mouse Monoclonal (IgG1,k) to Human RPA3
Mouse, Human
IP, WB
Unconjugated
100µg   $435.00
Select
Rabbit Polyclonal (IgG) to Mouse RPA3
Mouse, Rat
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human RPA3
Human
ELISA
Unconjugated
100µg   $375.00
Select
Rabbit Polyclonal (IgG) to Human RPA3
Mouse, Rat, Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Viewing 1-23 of 23 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).