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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
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Phone:
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TYRO3

TYRO3 protein tyrosine kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Gene Name: TYRO3 protein tyrosine kinase
Family/Subfamily: Protein Kinase , Axl
Synonyms: TYRO3, Brt, BYK, Dtk, Sky kinase, Sky, Tif, Tyrosine-protein kinase byk, Tyrosine-protein kinase SKY, Tyrosine-protein kinase DTK, TYRO3 protein tyrosine kinase, Tyrosine-protein kinase brt, RSE, Tyrosine-protein kinase RSE
Target Sequences: NM_006293 NP_006284.2 Q06418


TYRO3 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TYRO3
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg   $425.00
TYRO3 Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with TYRO3 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human TYRO3
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
TYRO3 Antibody - IHC of paraffin-embedded Kidney tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2D11] (IgG1) to Human TYRO3
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $345.00
TYRO3 Antibody - IHC of paraffin-embedded Kidney tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2D11] (IgG1) to Human TYRO3
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
TYRO3 Antibody - IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2C4] (IgG2b) to Human TYRO3
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1.3mg/ml   $345.00
TYRO3 Antibody - IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2C4] (IgG2b) to Human TYRO3
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
TYRO3 Antibody - Immunofluorescence of HeLa (Left) and MCF-7 (Right) cells using Tyro3 mouse monoclonal antibody (green).
Select
Mouse Monoclonal [clone 6D6F10] (IgG1) to Human TYRO3
Human
ELISA, IF
Unconjugated
100µl   $345.00
TYRO3 Antibody - IHC of paraffin-embedded pancreas tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI9B12] (IgG1) to Human TYRO3
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $345.00
TYRO3 Antibody - IHC of paraffin-embedded pancreas tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI9B12] (IgG1) to Human TYRO3
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
TYRO3 Antibody - Western blot - Anti-TYRO3 Picoband antibody
Select
Rabbit Polyclonal to Human TYRO3
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100µg   $355.00
TYRO3 Antibody - IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI4C8] (IgG1) to Human TYRO3
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl   1.3mg/ml   $345.00
TYRO3 Antibody - IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI4C8] (IgG1) to Human TYRO3
Human
IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
TYRO3 Antibody - IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI5B4] (IgG2a) to Human TYRO3
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $345.00
TYRO3 Antibody - IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI5B4] (IgG2a) to Human TYRO3
Human
IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
TYRO3 Antibody - IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2G2] (IgG2b) to Human TYRO3
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl   1.32mg/ml   $345.00
TYRO3 Antibody - IHC of paraffin-embedded breast tissue using anti-TYRO3 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2G2] (IgG2b) to Human TYRO3
Human
IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
TYRO3 Antibody - Anti-TYRO3 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TYRO3.
Select
Mouse Monoclonal [clone OTI5B7] (IgG2a) to Human TYRO3
Human
Flo, IF, IP
Unconjugated
100µl   1mg/ml   $345.00
TYRO3 Antibody - Anti-TYRO3 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TYRO3.
Select
Mouse Monoclonal [clone OTI5B7] (IgG2a) to Human TYRO3
Human
Flo, IF, IP
Unconjugated, Carrier-free
100µg   $395.00
TYRO3 Antibody - TYRO3 Antibody in Immunofluorescence (IF)
Select
Mouse Monoclonal [clone 1C10E8, 9A3F2] (IgG1) to Human TYRO3
Human
ICC, IF, WB
Unconjugated
100µl   $445.00
TYRO3 Antibody - TYRO3 Antibody - Lane 1: Western blot on normal human brain, Lane 2: Western blot on normal mouse brain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human TYRO3
Mouse, Human
ICC, IF, WB
Unconjugated
100µl   $335.00
TYRO3 Antibody
Select
Mouse Monoclonal [clone 1C10E8, 9A3F2] (IgG1) to Human TYRO3
Human
ELISA, IF, WB
Unconjugated
100µg   $345.00
TYRO3 Antibody - Immunofluorescence (IF) staining of methanol-fixed MCF-7 and HepG2 cells showing membrane and cytoplasmic localization using Tyro3 Monoclonal Antibody.
Select
Mouse Monoclonal (IgG1) to Human TYRO3
Human
ELISA, IF, WB
Unconjugated
100µl   $345.00
TYRO3 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human TYRO3
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human TYRO3
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
TYRO3 Antibody - Western Blot analysis of TYRO3 expression in transfected 293T cell line by TYRO3 monoclonal antibody (M05), clone 4F6.Lane 1: TYRO3 transfected lysate(96.9 KDa).Lane 2: Non-transfected lysate.
Select
Mouse Monoclonal [clone 4F6] (IgG2a,k) to Human TYRO3
Human
ELISA, RNAi, WB
Unconjugated
100µg   $365.00
Viewing 1-25 of 50 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).