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PTEN

phosphatase and tensin homolog

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.

Gene Name: phosphatase and tensin homolog
Family/Subfamily: Protein Phosphatase , PTEN
Synonyms: PTEN, 10q23del, BZS, DEC, GLM2, MHAM, Phosphatase and tensin homolog, PTEN1, MMAC1
Target Sequences: NM_000314 NP_000305.3 P60484

☰ Filters
Antibodies (471)
cDNAs (15)
ELISA Kits (11)
Proteins (9)
cDNA Clone (1)
Cell-Based (1)
Cell-Based Phosphorylation (2)
Custom (2)
Expression-Ready ORF Clone (14)
Over-Expression Lysate (3)
Primary (471)
Recombinant (6)
Sandwich (6)
PTEN (506)
Human (369)
Mouse (99)
Rat (93)
Bovine (5)
Chicken (3)
Dog (22)
Horse (3)
Monkey (7)
Pig (4)
Rabbit (3)
Zebrafish (5)
IHC (123)
IHC-Fr (4)
IHC-P (22)
WB (259)
Flo (8)
DB (182)
ELISA (184)
FLISA (15)
ICC (25)
IF (51)
IP (40)
Peptide-ELISA (8)
PLA (1)
rabbit (419)
mouse (49)
goat (2)
sheep (1)
IgG (322)
IgG1 (19)
IgG1,k (5)
IgG2a (12)
IgG2a,k (4)
IgG2b (1)
IgM,k (2)
monoclonal mc (55)
polyclonal pc (414)
recombinant monoclonal rmc (2)
1096CT4.3.3 (1)
17.A (1)
1B8 (2)
28H6 (1)
2C10 (1)
2G9 (1)
9E8 (1)
RBT-PTEN (2)
RM265 (1)
96-Well Microplate (4)
96-Well Strip Plate (7)
AF488 Conjugated (1)
AP Conjugated (23)
APC Conjugated (23)
Atto 390 Conjugated (2)
Atto 488 Conjugated (2)
Atto 594 Conjugated (4)
Azide-free (18)
Biotin Conjugated (24)
FITC Conjugated (25)
HRP Conjugated (22)
MaxLight 405 Conjugated (23)
MaxLight 490 Conjugated (23)
MaxLight 550 Conjugated (23)
MaxLight 650 Conjugated (23)
MaxLight 750 Conjugated (23)
PE (2)
PE Conjugated (21)
PerCP Conjugated (2)
Ready-to-Use (1)
RPE Conjugated (2)
Unconjugated (205)
C-Terminus (40)
aa305-335 (13)
aa368-398 (13)
pS229 (13)
pS294 (13)
pS362 (13)
pS385 (13)
pT366 (13)
pT382 (13)
pT383 (13)
pT401 (13)
pY174 (13)
pY176 (13)
pY240 (13)
pY315 (13)
pY336 (13)
pY68 (13)
N-Terminus (10)
Ser370 (7)
pSer370 (7)
pSer380 (7)
320-400 aa (6)
Ser385 (5)
Ser380/Thr382/Thr383 (3)
pSer380/Thr382/Thr383/Ser385 (3)
pSer385 (3)
310-390 aa (2)
aa254-270 (2)
aa325-375 (2)
aa386-403 (2)
Internal (1)
Ser380 (1)
aa1-50 (1)
aa152-200 (1)
aa161-191 (1)
aa2-403 (1)
aa215-245 (1)
aa225-255 (1)
aa280-310 (1)
aa300-330 (1)
aa304-403 (1)
aa321-351 (1)
aa347-377 (1)
aa351-380 (1)
aa365-395 (1)
aa370-400 (1)
aa377-403 (1)
aa53-82 (1)
aa91-403 (1)
around the acetylation site of K402. (1)
p370 (1)
p380 (1)
p380/382/383 (1)
p385 (1)
pSer380 pThr382Thr383 (1)
pSer380/ (1)
pSer380/Thr382/Ser385 (1)
pSer380/Thr382/Thr383 (1)
pSer380/Thr383/Ser385 (1)
No (506)
Adherent Cell Cultures (3)
Cell Culture Supernatants (1)
Cell Lysates (3)
Plasma (4)
Serum (4)
Tissue Homogenates (5)
6His, N-terminus (1)
8His, N-terminus (1)
DDK (Flag), C-terminus (1)
DDK (Flag), N-terminus (1)
GFP, C-terminus (2)
GFP, N-terminus (1)
GST (1)
HA, C-terminus (1)
HA, N-terminus (1)
His (2)
His, C-terminus (1)
His, N-Terminal (1)
His, N-terminus (1)
Myc, C-terminus (1)
Myc, N-terminus (1)
Myc-DDK (Flag) (3)
OFP, C-terminus (1)
OFP, N-terminus (1)
Untagged (2)
Human (15)
Lentiviral (1)
Mammalian (13)
Human (8)
293T Cells (1)
E. coli (4)
HEK 293 Cells (3)
Sf9 Cells (1)
Purified (2)
Low endotoxin level (2)
Biologically active (1)
PTEN ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$687
PTEN Protein
Select
E. coli
6His, N-terminus
48.6 kDa
10 µg/$265; 50 µg/$384; 100 µg/$612; 200 µg/$765; 1 mg/$1,748
Select
PTEN Rabbit anti-Human Monoclonal (C-Terminus) Antibody
ELISA, Flo, ICC, IHC, IP, WB
Unconjugated
20 µg/$523
Select
PTEN Rabbit anti-Human Monoclonal (C-Terminus) Antibody
Flo, ICC, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$455
Select
PTEN Rabbit anti-Human Monoclonal (pSer380) Antibody
ICC, IHC, WB
Unconjugated
100 µl/$487
PTEN Antibody - Immunohistochemical analysis of PTEN staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
PTEN Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Rat, Mouse, Dog, Human
IHC, IP, WB
Unconjugated
100 µl/$289
PTEN Antibody
Select
PTEN Rabbit anti-Human Polyclonal (C-Terminus) Antibody
ELISA, IHC
Unconjugated
100 µl/$309
Select
PTEN Rabbit anti-Human Monoclonal (C-Terminus) (AF488) Antibody
ELISA, Flo, WB
AF488 Conjugated
500 µl/$511
Select
PTEN Rabbit anti-Human Monoclonal (RM265) Antibody
Human
IHC, WB
Unconjugated
50 µl/$466
PTEN Antibody - Confocal immunofluorescence analysis of Hela (left) and HepG2 (right) cells using PTEN mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Select
PTEN Mouse anti-Human Monoclonal (1B8) Antibody
Mouse, Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$383
Select
PTEN Rabbit anti-Human Monoclonal (pSer380 pThr382Thr383) Antibody
ELISA, WB
Unconjugated
20 µl/$449; 100 µl/$688
Select
PTEN Rabbit anti-Human Polyclonal (pSer380) Antibody
ELISA, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$687
PTEN Antibody - Immunohistochemical analysis of PTEN staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
PTEN Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Pig, Human, Monkey
ICC, IF, IHC, WB
Unconjugated
30 µl/$245; 100 µl/$289; 200 µl/$341
PTEN Antibody - Immunohistochemical analysis of PTEN (pS380/T382/T383) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
PTEN Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Rat, Mouse, Dog, Human
ICC, IF, IHC, IP, WB
Unconjugated
30 µl/$253; 100 µl/$305; 200 µl/$369
PTEN Antibody - 1:200 staining human colon carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
PTEN Rabbit anti-Human Polyclonal (pSer370) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
PTEN Antibody - Confocal Immunofluorescence (IF) analysis of HeLa (left) and HepG2 (right) cells using PTEN Monoclonal Antibody (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Select
PTEN Mouse anti-Human Monoclonal Antibody
Mouse, Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$371
Select
PTEN Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$376
PTEN Antibody - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with PTEN antibody.
Select
PTEN Rabbit anti-Human Polyclonal Antibody
Human
Flo, IF, IHC, WB
Unconjugated
20 µg/$340; 100 µg/$501
PTEN Antibody - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with PTEN antibody.
Select
PTEN Rabbit anti-Human Polyclonal Antibody
Human
Flo, IF, IHC, WB
Unconjugated
100 µg/$501
Select
PTEN Rabbit anti-Human Polyclonal (aa305-335) (Biotin) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$767
Select
PTEN Rabbit anti-Human Polyclonal (aa305-335) (FITC) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$767
Select
PTEN Rabbit anti-Human Polyclonal (aa305-335) (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$767
Select
PTEN Rabbit anti-Human Polyclonal (aa305-335) (AP) Antibody
Human
ELISA, ICC, IF, IHC, WB
AP Conjugated
200 µl/$767
Select
PTEN Rabbit anti-Human Polyclonal (aa305-335) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$767
Select
PTEN Rabbit anti-Human Polyclonal (aa305-335) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$767
Viewing 1-25 of 506 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).