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PRKCZ / PKC-Zeta

protein kinase C, zeta

Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis.

Gene Name: protein kinase C, zeta
Family/Subfamily: Protein Kinase , PKC
Synonyms: PRKCZ, PKC-ZETA, PKC2, Pkcz, PKCzeta, Protein kinase c zeta, Protein kinase C zeta type, NPKC-zeta, PKC Zeta, Protein kinase C, zeta, Protein kinase Czeta
Target Sequences: NM_002744 NP_002735.3 Q05513

☰ Filters
Antibodies (102)
ELISA Kits (15)
cDNAs (15)
Proteins (14)
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Cell-Based (1)
Cell-Based Phosphorylation (2)
Expression-Ready ORF Clone (14)
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PRKCZ / PKC-Zeta (146)
Human (79)
Mouse (59)
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PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
PRKCZ / PKC-Zeta Antibody - Immunohistochemical analysis of PKC zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Rat, Rabbit, Mouse, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$289
PRKCZ / PKC-Zeta Antibody - Anti-PRKCZ / PKC-Zeta antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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PRKCZ / PKC-Zeta Rabbit anti-Human Monoclonal (Internal) (EP1490(2)) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$485
PRKCZ / PKC-Zeta Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (aa376-425) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$505
PRKCZ / PKC-Zeta Antibody - IHC of p-PKC (T410) pAb in paraffin-embedded human lung carcinoma tissue.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (pThr410) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$327; 100 µl/$409
PRKCZ / PKC-Zeta Antibody - Western blot of Phospho-PKC zeta (T560) antibody
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (500-580 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
100 µl/$394
PRKCZ / PKC-Zeta Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (pThr410) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
PRKCZ / PKC-Zeta Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (pThr560) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
PRKCZ / PKC-Zeta Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
PRKCZ / PKC-Zeta Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using PKC ? (Ab-560) antibody.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (p560) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$347
PRKCZ / PKC-Zeta Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PKC? (Ab-410) antibody.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (p410) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$347
PRKCZ / PKC-Zeta Antibody - P-peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PKC? (phospho-Thr410) antibody.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (pThr410) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$347
PRKCZ / PKC-Zeta Antibody - Western blot of PKC zeta expression in PMA treated COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$347
PRKCZ / PKC-Zeta Antibody - Western blot of PKC zeta phosphorylation expression in PMA treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (pThr410) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$347
PRKCZ / PKC-Zeta Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using PKC zeta (Phospho-Thr410) Antibody. The picture on the right is blocked with the phospho peptide.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (pThr410) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$457
PRKCZ / PKC-Zeta Antibody - Western blot of PKC zeta antibody
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (350-430 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
PRKCZ / PKC-Zeta Antibody - Western blot of PKC zeta antibody
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (500-580 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
PRKCZ / PKC-Zeta Antibody - Western blot of Phospho-PKC zeta (T410) antibody
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (350-430 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
PRKCZ / PKC-Zeta Antibody - IHC of PKC (P556) pAb in paraffin-embedded human brain tissue.
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (Pro556) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$319; 100 µl/$393
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PRKCZ / PKC-Zeta Rabbit anti-Rat Polyclonal (aa579-592) Antibody
Mouse, Rat
ELISA, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µl/$478
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal (pThr410/Thr403) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$611
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PRKCZ / PKC-Zeta Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$562
Viewing 1-25 of 146 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).