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ACE2 / ACE-2

angiotensin I converting enzyme 2

Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes).

Gene Name: angiotensin I converting enzyme 2
Family/Subfamily: Protease , Metallopeptidase M2
Synonyms: ACE2, ACE-related carboxypeptidase, ACEH, Metalloprotease MPROT15, SARS-CoV2 Coronavirus Receptor, SARS-CoV-2 Coronavirus Receptor, COVID-19 viral receptor
Target Sequences: NM_021804 NP_068576.1 Q9BYF1

Publications (6)

1
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianos SG. Journal of virology. 2013 87:8017-28. (IHC; Human) [Full Text Article] [PubMed:23678171] [PMC:PMC3700180] Related Antibodies: LS-C122669.
2
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension. Francine Duchatsch, Paula B Constantino, Naiara A Herrera, Mayara F Fabrício, Lidieli P Tardelli, Aline M Martuscelli, Thiago J Dionísio, Carlos F Santos, Sandra L Amaral. Journal of the American Society of Hypertension : JASH. 2018 August;12:605-613. [Full Text Article] [PubMed:29945776]
3
Reduced severe acute respiratory syndrome coronavirus 2 entry factors and enhanced innate immune gene expression in the nasal epithelium of pregnant rats. Arvind Palanisamy, Tusar Giri. American journal of obstetrics and gynecology. 2020 October; [Full Text Article] [PubMed:33039392] [PMC:PMC7544630] Related Antibodies: LS-C763699.
4
Pregnancy as a "golden opportunity" for patient activation and engagement. Lynn M Yee, Melissa A Simon, William A Grobman, Priya V Rajan. American journal of obstetrics and gynecology. 2020 September; [Full Text Article] [PubMed:32979375] Related Antibodies: LS-C763699.
5
Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia. Emma N Bardsley, Oliver C Neely, David J Paterson. Journal of molecular and cellular cardiology. 2020 Jan;138:234-243. [Full Text Article] [PubMed:31836539] [PMC:PMC7049903]
6
Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice. Chhabra KH, Xia H, Pedersen KB, Speth RC, Lazartigues E. American journal of physiology. Endocrinology and metabolism. 2013 Apr;304:E874-84. [Full Text Article] [PubMed:23462816] [PMC:PMC3625779] Related Antibodies: LS-B3197.
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Antibodies (114)
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ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
0.05 mg/$440
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of Human Kidney.  Positive staining of proximal renal tubules.  : Formalin-Fixed, Paraffin-Embedded (FFPE)
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa140-172) Antibody
Human
IHC-P
Unconjugated
200 µl/$440
ACE2 / ACE-2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ACE2 / ACE-2 Mouse anti-Human Monoclonal (aa18-237) (1G4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.05 mg/$440
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa684-733) Antibody
Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa684-733) (HRP) Antibody
Pig, Orangutan, Gibbon, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$459
ACE2 / ACE-2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ACE2 / ACE-2 Mouse anti-Human Monoclonal (AC18F) Antibody
Human
ELISA, Flo, IHC-P, WB
Unconjugated
50 µg/$320; 100 µg/$369
ACE2 / ACE-2 Antibody - Western blot analysis using anti-ACE2 (human), mAb (AC18F) at 1: 2,000 dilution. 1. hACE2 (Fc protein). 2. hACE2 (Ecto domain) (FLAG-tagged). 3. Other hGITR (Fc protein) (control).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACE2 / ACE-2 Mouse anti-Human Monoclonal (Biotin) (AC18F) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
50 µg/$369
ACE2 / ACE-2 Antibody - Western blot analysis of ACE2 expression in HeLa (A); SP20 (B); PC12 (C) whole cell lysates.
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$311
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ACE2 / ACE-2 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$280; 120 µl/$343; 200 µl/$451
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ACE2 / ACE-2 Goat anti-Human Polyclonal (aa18-740) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$819
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$522
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$835
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$809
ACE2 / ACE-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$696
ACE2 / ACE-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa140-172) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$825
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal (aa140-172) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$825
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ACE2 / ACE-2 Mouse anti-Human Monoclonal (aa18-740) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$771
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ACE2 / ACE-2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$284; 100 µg/$348
ACE2 / ACE-2 Assay Kit - (a) Kinetic activity curves using different amounts of ACE2 Positive Control in the assay. (b) ACE2 activity was measured for different types of rat tissue samples (total protein in lung and kidney; 17 µg and 23 µg respectively), and human kidney tissue sample (10 µg total protein) in presence (+ Inhibitor) and absence (- Inhibitor) of ACE2 Inhibitor. (c) Spiked ACE2 activity and inhibition measured in HEK293 cell lysate (total protein: 37 µg).
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Enzymatic Activity Assay
ACE2 / ACE-2
Spectrophotometry (fluorometric)
100 Assays/$540
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
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Human Cells
Mouse IgG1 Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
110 kDa
20 µg/$641; 100 µg/$1,423
Viewing 1-25 of 162 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).