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MME / CD10

membrane metallo-endopeptidase

MME / CD10 is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Gene Name: membrane metallo-endopeptidase
Family/Subfamily: Protease , Metallopeptidase M13
Synonyms: MME, Atriopeptidase, CALLA, CD10, EPN, Membrane metallo-endopeptidase, NEP, Neprilysin, Neutral endopeptidase, Neutral endopeptidase 24.11, CD10 antigen, Enkephalinase, Neprylisin, SFE, Skin fibroblast elastase
Target Sequences: NM_000902 NP_000893.2 P08473

Publications (1)

1
A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. Denny MF, Yalavarthi S, Zhao W, Thacker SG, Anderson M, Sandy AR, McCune WJ, Kaplan MJ. Journal of immunology (Baltimore, Md. : 1950). 2010 184:3284-97. [PubMed:20164424] [PMC:PMC2929645] Related Antibodies: LS-C41007.

☰ Filters
Antibodies (230)
cDNAs (52)
Proteins (34)
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MME / CD10 (335)
Human (210)
Mouse (59)
Rat (53)
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Bat (4)
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monoclonal mc (129)
polyclonal pc (100)
recombinant monoclonal rmc (1)
113 (1)
13 (1)
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aa411-750 (10)
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491-540 aa, Internal (1)
CD10 (1)
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Select
MME / CD10 Mouse anti-Human Monoclonal (Biotin) (MEM-78) Antibody
Human
Flo, IP
Biotin Conjugated
0.1 mg/$327
MME / CD10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
MME / CD10 Rabbit anti-Human Polyclonal (aa274-302) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$515
Select
MME / CD10 Mouse anti-Human Monoclonal (SS2/36) Antibody
Human
IHC, IHC-Fr
Unconjugated
500 µl/$266
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$792
MME / CD10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$835
MME / CD10 Antibody - Nalm-6 cell line stained with purified HI10a and detected with anti-mouse IgGs-FITC
Select
MME / CD10 Mouse anti-Human Monoclonal (HI10a) Antibody
Human, Monkey, Baboon
Flo
Unconjugated
100 µg/$262
MME / CD10 Antibody - Anti-CD10 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
Cancer Pathology
Cancer
MME / CD10 Mouse anti-Human Monoclonal (56C6) Antibody
Rat, Human
IHC, IHC-P
Unconjugated
0.1 ml/$845
MME / CD10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
MME / CD10 Mouse anti-Human Monoclonal (56C6) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.05 ml/$460
MME / CD10 Antibody - IHC of paraffin-embedded prostate cancer tissues using CD10 mouse monoclonal antibody with DAB staining.
Select
MME / CD10 Mouse anti-Human Monoclonal (aa52-246) (7D4B1) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$415
Select
MME / CD10 Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µl/$488
Select
MME / CD10 Mouse anti-Human Monoclonal (SN5c) Antibody
Human
Flo, IHC-Fr, IP, WB
Unconjugated
0.1 mg/$363
MME / CD10 Antibody - Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
MME / CD10 Rabbit anti-Human Polyclonal (E19-P) Antibody
IHC, IHC-P
Unconjugated
100 µl/$525
MME / CD10 Antibody
Select
MME / CD10 Mouse anti-Human Monoclonal (2A1H5E1) Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$357
MME / CD10 Antibody - Immunofluorescence staining of MME in MCF7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-human MME monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Cell membrane.
Select
MME / CD10 Rabbit anti-Human Monoclonal (Preservative Free) (113) Antibody
Human
ICC, IF
Unconjugated, Preservative Free
50 µl/$290; 100 µl/$350
Select
MME / CD10 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo, WB
Biotin Conjugated
100 µg/$533
Select
MME / CD10 Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$700
MME / CD10 Antibody - Surface staining of human peripheral blood with anti-human CD10 (MEM-78) APC.
Select
MME / CD10 Mouse anti-Human Monoclonal (APC) (MEM-78) Antibody
Human
Flo, IP
APC Conjugated
100 Tests/$355
MME / CD10 Antibody - Immunohistochemical staining of paraffin-embedded Raji cell pellets using anti-MME. (CD10) mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH9.0) at 120°C for 2.5 min. (1:600)
Select
MME / CD10 Mouse anti-Human Monoclonal (aa411-750) (UMAB236) Antibody
Human
Flo, IHC, PMA, WB
Unconjugated
100 µl/$464
MME / CD10 Antibody - Immunohistochemical staining of paraffin-embedded Raji cell pellets using anti-MME. (CD10) mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH9.0) at 120°C for 2.5 min. (1:600)
Select
MME / CD10 Mouse anti-Human Monoclonal (aa411-750) (Carrier-free) (UMAB236) Antibody
Human
Flo, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$508
MME / CD10 Antibody - MME/CD10 western blot of CEM cell line lysates (35 ug/lane). The MME/CD10 antibody detected the MME/CD10 protein (arrow).
Select
MME / CD10 Mouse anti-Human Monoclonal (aa272-300) Antibody
Human
WB
Unconjugated
400 µl/$381
MME / CD10 Antibody - MME / CD10 antibody Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
MME / CD10 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100 µl/$434
MME / CD10 Antibody - Western blot of recombinant MME / CD10.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
MME / CD10 Rabbit anti-Human Polyclonal (aa565-750) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$294; 200 µl/$334; 500 µl/$467; 1 ml/$533
MME / CD10 Antibody - Anti-MME / CD10 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Cancer Pathology
Cancer
MME / CD10 Rabbit anti-Human Polyclonal (G27-P) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
100 µl/$460
Select
MME / CD10 Mouse anti-Human Monoclonal (3G6B11) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$415
Select
MME / CD10 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$376
Viewing 1-25 of 335 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).