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DEFA5 / Defensin 5

defensin, alpha 5, Paneth cell-specific

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.

Gene Name: defensin, alpha 5, Paneth cell-specific
Synonyms: DEFA5, DEF5, Defensin, alpha 5, Defensin 5, Defensin-5, HD-5, HD5(20-94)
Target Sequences: NM_021010 NP_066290.1 Q01523

Publications (5)

1
Human defensin 5 expression in intestinal metaplasia of the upper gastrointestinal tract. Shen B, Porter EM, Reynoso E, Shen C, Ghosh D, Connor JT, Drazba J, Rho HK, Gramlich TL, Li R, Ormsby AH, Sy MS, Ganz T, Bevins CL. Journal of clinical pathology. 2005 58:687-94. [PubMed:15976333] [PMC:PMC1770712]
2
Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:18129-34. (IHC, WB) [PubMed:16330776] [PMC:PMC1306791]
3
Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. Wehkamp J, Chu H, Shen B, Feathers RW, Kays RJ, Lee SK, Bevins CL. FEBS letters. 2006 580:5344-50. (ICC, IHC) [PubMed:16989824]
4
Lowered expression of galectin-2 is associated with lymph node metastasis in gastric cancer. Jung JH, Kim HJ, Yeom J, Yoo C, Shin J, Yoo J, Kang CS, Lee C. Journal of gastroenterology. 2012 47:37-48. (WB; Human) [PubMed:22015694]
5
Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes. Kim HJ, Kang UB, Lee H, Jung JH, Lee ST, Yu MH, Kim H, Lee C. Journal of proteomics. 2012 75:2983-97. [PubMed:22178445]
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☰ Filters
Antibodies (44)
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DEFA5 / Defensin 5 (70)
Human (46)
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rabbit (23)
mouse (21)
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aa20-94 (19)
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DEFA5 / Defensin 5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$792
DEFA5 / Defensin 5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$654
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (8C8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (Biotin) (8C8) Antibody
Human
IF, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$406
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (DY650) (8C8) Antibody
Human
IF, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$406
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (DY488) (8C8) Antibody
Human
IF, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$406
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (DY550) (8C8) Antibody
Human
IF, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$406
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DEFA5 / Defensin 5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$771
DEFA5 / Defensin 5 Antibody - Anti-DEFA5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$505
DEFA5 / Defensin 5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
Select
DEFA5 / Defensin 5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$740
Select
DEFA5 / Defensin 5 Mouse anti-Rabbit Monoclonal (R3) Antibody
Rabbit
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$987
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (Concentrated) (R3) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated, Concentrated
100 µg/$867
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (aa20-94) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$836
DEFA5 / Defensin 5 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
DEFA5 / Defensin 5 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$654
DEFA5 / Defensin 5 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
GST, N-terminus
1 mg/$1,646; 100 µg/$565; 20 µg/$395
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (8C8) Antibody
Human
IHC, IHC-Fr, WB
Unconjugated
100 µg/$677; 500 µg/$1,515
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (aa20-94) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$299; 200 µl/$342; 500 µl/$483; 1 ml/$553
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (aa20-94) (HRP) Antibody
Human
ICC, IP, WB
HRP Conjugated
200 µl/$384; 500 µl/$567; 1 ml/$707
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (aa20-94) (Biotin) Antibody
Human
ICC, IP, WB
Biotin Conjugated
200 µl/$356; 500 µl/$511; 1 ml/$597
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (aa20-94) (PE) Antibody
Human
ICC, IP, WB
PE Conjugated
200 µl/$483; 500 µl/$824; 1 ml/$900
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
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DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (aa20-94) (APC, Cy7) Antibody
Human
ICC, IP, WB
APC, Cy7 Conjugated
1 ml/$1,175
DEFA5 / Defensin 5 Antibody - Western blot of recombinant DEFA5 / Defensin 5.
Select
DEFA5 / Defensin 5 Mouse anti-Human Monoclonal (aa20-94) (APC) Antibody
Human
ICC, IP, WB
APC Conjugated
200 µl/$483; 500 µl/$824; 1 ml/$900
Select
DEFA5 / Defensin 5 Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$620
Viewing 1-25 of 70 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).