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CCL2 / MCP1

chemokine (C-C motif) ligand 2

CCL2 / MCP1 is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Gene Name: chemokine (C-C motif) ligand 2
Family/Subfamily: Intercrine , Intercrine beta
Synonyms: CCL2, C-C motif chemokine 2, Chemokine (C-C motif) ligand 2, GDCF-2, HC11, HSMCR30, MCP1, SCYA2, Small-inducible cytokine A2, Monocyte secretory protein JE, MCAF, MCP-1, Monocyte chemotactic protein 1, SMC-CF
Target Sequences: NM_002982 NP_002973.1 P13500

Publications (8)

1
Protective Role of Interleukin-17 in Murine NKT Cell-Driven Acute Experimental Hepatitis. Zenebech Wondimu, Tania Santodomingo-Garzon, Tai Le, and Mark G. Swain. The American journal of pathology. 2010 177:2334-46. (IHC-P; Mouse) [Full Text Article] [PubMed:20847291] [PMC:PMC2966792]
2
Reduction of activated macrophages after ischaemia-reperfusion injury diminishes oxidative stress and ameliorates renal damage. Fet NG, Fiebeler A, Klinge U, Park JK, Barth S, Thepen T, Tolba RH. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 27:3149-55. (IHC; Rat) [PubMed:22402584]
3
Infection with Mycobacterium avium subsp. paratuberculosis results in rapid interleukin-1 release and macrophage transepithelial migration. Lamont EA, O'Grady SM, Davis WC, Eckstein T, Sreevatsan S. Infection and immunity. 2012 80:3225-35. (Human) [PubMed:22778093] [PMC:PMC3418758]
4
Small heat shock proteins induce a cerebral inflammatory reaction. Bruinsma IB, de Jager M, Carrano A, Versleijen AA, Veerhuis R, Boelens W, Rozemuller AJ, de Waal RM, Verbeek MM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:11992-2000. (ICC; Human) [Full Text Article] [PubMed:21849559] Related Antibodies: LS-C8642.
5
Comparative pulmonary toxicity of a DWCNT and MWCNT-7 in rats. El-Gazzar AM, Abdelgied M, Alexander DB, Alexander WT, Numano T, Iigo M, Naiki A, Takahashi S, Takase H, Hirose A, Kannno J, Elokle OS, Nazem AM, Tsuda H. Archives of toxicology. 2019 January;93:49-59. [Full Text Article] [PubMed:30341734] [PMC:PMC6343020]
6
Renal denervation and CD161a immune ablation prevent cholinergic hypertension and renal sodium retention. Nandita Raikwar, Cameron Braverman, Peter M Snyder, Robert A Fenton, David K Meyerholz, Francois M Abboud, Sailesh C Harwani. American journal of physiology. Heart and circulatory physiology. 2019 September;317:H517-H530. [Full Text Article] [PubMed:31172810] [PMC:PMC6766722] Related Antibodies: LS-C104751.
7
Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. Akiko Nakayama, Julián Albarrán-Juárez, Guozheng Liang, Kenneth Anthony Roquid, András Iring, Sarah Tonack, Min Chen, Oliver J Müller, Lee S Weinstein, Stefan Offermanns. JCI insight. 2020 December;5: [Full Text Article] [PubMed:33268595] [PMC:PMC7714404] Related Antibodies: LS-C169178.
8
Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis. Divya Bhatia, Kuei-Pin Chung, Kiichi Nakahira, Edwin Patino, Michelle C Rice, Lisa K Torres, Thangamani Muthukumar, Augustine Mk Choi, Oleh M Akchurin, Mary E Choi. JCI insight. 2019 December;4: [Full Text Article] [PubMed:31639106] [PMC:PMC6962025]
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CCL2 / MCP1 Antibody - Anti-CCL2 / MCP1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
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CCL2 / MCP1 Rabbit anti-Human Polyclonal (aa62-89) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$515
CCL2 / MCP1 Antibody - IHC of paraffin-embedded liver cancer tissues using CCL2 mouse monoclonal antibody with DAB staining.
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CCL2 / MCP1 Mouse anti-Human Monoclonal (2D8) Antibody
Mouse, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$415
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CCL2 / MCP1 Mouse anti-Human Monoclonal (5D3-F7 (aka MNA.1)) Antibody
Human
ELISA, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$800
CCL2 / MCP1 Antibody - Western Blot (reducing) of CCL2 / MCP-1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CCL2 / MCP1 Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
CCL2 / MCP1 Antibody - Anti-MCP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CCL2 / MCP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CCL2 / MCP1 Antibody - Immunohistochemistry of CCL2 in spleen tissue with CCL2 antibody at 5 ug/ml.
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CCL2 / MCP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.1 mg/$420
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CCL2 / MCP1 Rat anti-Mouse Monoclonal (aa102-130) (ECE.2) Antibody
Mouse
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$486
CCL2 / MCP1 Antibody - Western Blot (non-reducing) of CCL2 / MCP-1 antibody
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CCL2 / MCP1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$297
CCL2 / MCP1 Antibody
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CCL2 / MCP1 Hamster-Armenian anti-Mouse Monoclonal (2H5) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$253
CCL2 / MCP1 Antibody - Immunohistochemistry of paraffin-embedded human colon tissue.
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CCL2 / MCP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
CCL2 / MCP1 Antibody - Western Blot (non-reducing) of CCL2 / MCP-1 antibody
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CCL2 / MCP1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
CCL2 / MCP1 Antibody - Anti-Human MCP-1 Antibody - Western Blot. Anti-human MCP-1 by western blot shows detection of recombinant human MCP-1 raised in E. coli. Recombinant (0.1 ug, 8.6 kD) protein was loaded onto and resolved by SDS-PAGE, then transferred to nitrocellulose. The membrane was blocked with 1% BSA in TBST for 30 min at RT, followed by incubation with Anti-Human MCP-1. After washing, membrane was probed with secondary antibody Dylight 649 Conjugated Anti-Rabbit IgG (H&L) (Goat) Antibody ( diluted 1:20000 in blocking buffer (p/n MB-070) for 30 min. at RT. Data was collected using Bio-Rad VersaDoc 4000 MP imaging system.
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CCL2 / MCP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$485
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CCL2 / MCP1 Mouse anti-Human Monoclonal (MNA1) Antibody
Human
Flo, Func, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$486
CCL2 / MCP1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
2.048 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$537
CCL2 / MCP1 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
3 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$537
CCL2 / MCP1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Ascites, Cell Culture Supernatants, Cerebrospinal Fluid, Plasma, Saliva, Serum, Tissue Homogenates, Urine
1 Plate/$734
CCL2 / MCP1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$653
CCL2 / MCP1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$653
CCL2 / MCP1 Protein - Recombinant Monocyte Chemotactic Protein 1 By SDS-PAGE
Select
E. coli
His
10.2 kDa
10 µg/$284; 50 µg/$498; 100 µg/$796; 200 µg/$993; 1 mg/$2,145
CCL2 / MCP1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$653
CCL2 / MCP1 Antibody - Western Blot (non-reducing) of CCL2 / MCP-1 antibody
Select
CCL2 / MCP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
CCL2 / MCP1 Antibody - Anti-Bovine CCL2 Antibody - Western Blot. Western blot of protein-A purified anti-bovine CCL2 antibody shows detection of recombinant bovine CCL2 at 8.8kD (arrow) raised in yeast. Protein was purified and resolved by SDS-PAGE, then transferred to PVDF membrane. Membrane was blocked with 3% BSA (BSA-30, diluted 1:10), and probed with Inc. Anti-bovine CCL2. After washing, membrane was probed with Dylight 649 Conjugated Anti-Rabbit IgG (H&L) (Donkey) Antibody (.
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CCL2 / MCP1 Rabbit anti-Bovine Polyclonal (Lyophilized) Antibody
Bovine
ELISA, WB
Unconjugated, Lyophilized
100 µg/$485
CCL2 / MCP1 Antibody - MCP-1 Antibody in Immunohistochemistry (IHC)
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CCL2 / MCP1 Mouse anti-Human Monoclonal (2D8) Antibody
Mouse, Human, Non-Human Primate
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$460
Select
CCL2 / MCP1 Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-Fr
Unconjugated
100 µg/$493
Select
CCL2 / MCP1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$381; 100 µg/$461
Viewing 1-25 of 458 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).