IPO4

Importin 4

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

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IPO4 (3)

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No (3)

Tag

Myc-DDK (Flag) (3)

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Human (2)

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293T Cells (1)

HEK 293 Cells (2)

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Human IPO4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83784

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118.5 kDa

Price:

20 µg/$150

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IPO4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109864

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118.5 kDa

Price:

100 µg/$494

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Human IPO4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69069

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118.5 kDa

Price:

20 µg/$1,107

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