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MAPT / Tau

microtubule-associated protein tau

Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU.

Gene Name: microtubule-associated protein tau
Synonyms: MAPT, FTDP-17, MSTD, Neurofibrillary tangle protein, PHF-tau, MTBT2, PPND, DDPAC, MAPTL, MTBT1, Paired helical filament-tau, TAU
Target Sequences: NM_016835 P10636

Publications (3)

1
Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease. Puri R, Suzuki T, Yamakawa K, Ganesh S. The Journal of biological chemistry. 2009 284:22657-63. (IHC, WB) [PubMed:19542233] [PMC:PMC2755673]
2
Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells. Fu ZQ, Shao QL, Shen JL, Zhang YJ, Zhao XX, Yao L. Journal of neuroimmunology. 2010 221:15-24. (ICC, WB) [PubMed:20163877]
3
Serum levels of tau protein increase according to the severity of the injury in DAI rat model. Keisuke Tomita, Taka-Aki Nakada, Taku Oshima, Rui Kawaguchi, Shigeto Oda. F1000Research. 2020 December;9:29. [Full Text Article] [PubMed:33299544] [PMC:PMC7707115]

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MAPT / Tau Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
MAPT / Tau Mouse anti-Human Monoclonal (MCA-2E9) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
Select
MAPT / Tau Mouse anti-Human Monoclonal Antibody
Rat, Human
WB
Unconjugated
100 µg/$727
MAPT / Tau Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MAPT / Tau Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$555
Select
MAPT / Tau Rabbit anti-Human Polyclonal (aa677-707) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$614
Select
MAPT / Tau Rabbit anti-Human Polyclonal (aa677-707) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$767
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MAPT / Tau Rabbit anti-Human Polyclonal (aa677-707) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$767
MAPT / Tau ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$809
MAPT / Tau ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
MAPT / Tau ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$654
MAPT / Tau ELISA Kit
Select
Sandwich
96-Well Microplate
Human
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$654
Select
MAPT / Tau Mouse anti-Bovine Monoclonal (Magnetic beads) (TAU-93) Antibody
Mouse, Bovine, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$363
MAPT / Tau ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$792
MAPT / Tau ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$654
MAPT / Tau Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
500 µg/$1,279; 100 µg/$548; 20 µg/$385
Select
MAPT / Tau Rabbit anti-Human Polyclonal (680-760 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
MAPT / Tau Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
MAPT / Tau Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$440
MAPT / Tau ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
45.85kD
10 µg/$274; 50 µg/$421; 500 µg/$1,439; 1 mg/$2,055
Select
MAPT / Tau Mouse anti-Bovine Monoclonal (TAU-5) Antibody
Mouse, Sheep, Bovine, Rat, Human
IF, IP, WB
Unconjugated
500 µl/$631
Select
MAPT / Tau Mouse anti-Bovine Monoclonal (Biotin) (TAU-5) Antibody
Mouse, Sheep, Bovine, Rat, Human
IF, IP, WB
Biotin Conjugated
500 µl/$809
Select
MAPT / Tau Rabbit anti-Human Polyclonal (pThr205) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$327; 100 µl/$409
Select
MAPT / Tau Mouse anti-Human Monoclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$231; 100 µg/$293; 200 µg/$324; 500 µg/$442
Select
MAPT / Tau Rabbit anti-Human Polyclonal (660-740 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
MAPT / Tau Antibody - Western blot analysis of extracts from mouse brain tissue using Tau (Ab-205) antibody (Line 1 and 2) and Tau (phospho- Thr205) antibody (Line 3 and 4).
Select
MAPT / Tau Rabbit anti-Human Polyclonal (pThr205) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$347
MAPT / Tau Antibody - Western blot of extracts from mouse brain and CAD cells, using Tau, phosphorylated (Ser396). The phospho-specificity of the antibody was verified by peptide blocking using no peptide, phospho-peptide or nonphospho-peptide.
Select
MAPT / Tau Mouse anti-Human Monoclonal (pSer396) Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$611
Viewing 1-25 of 496 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).