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MSLN / Mesothelin

mesothelin

This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described. Their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. MPF is a cytokine with megakaryocyte potentiating activity. Mesothelin null mutant mice show a normal phenotype suggesting that mesothelin function is not essential for growth or reproduction in mice (Bera et al., 2000).

Gene Name: mesothelin
Synonyms: MSLN, CAK1 antigen, MPF, SMRP, Mesothelin, CAK1
Target Sequences: NM_013404 NP_037536.2 Q13421

Publications (3)

1
New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA. Onda M, Willingham M, Nagata S, Bera TK, Beers R, Ho M, Hassan R, Kreitman RJ, Pastan I. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 11:5840-6. [PubMed:16115924] Related Antibodies: LS-C154007.
2
A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express a-gal epitopes. Furukawa K, Tanemura M, Miyoshi E, Eguchi H, Nagano H, Matsunami K, Nagaoka S, Yamada D, Asaoka T, Noda T, Wada H, Kawamoto K, Goto K, Taniyama K, Mori M, Doki Y. PloS one. 2017 12:e0184901. (IHC-P; Human) [Full Text Article] [PubMed:29077749]
3
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. Watanabe K, Luo Y, Da T, Guedan S, Ruella M, Scholler J, Keith B, Young RM, Engels B, Sorsa S, Siurala M, Havunen R, Tähtinen S, Hemminki A, June CH. JCI insight. 2018 April;3:pii: 99573. (Mouse) [Full Text Article] [PubMed:29618658] [PMC:PMC5928866] Related Antibodies: LS-C179484.

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MSLN / Mesothelin Antibody - Anti-Mesothelin Antibody - Immunohistochemistry. Immunohistochemistry using anti-mesothelin antibodies to detect mesothelin in PEFF human tissue sections treated by antigen retrieval methods. Anti-mesothelin primary antibodies were used to label these sections as follows: C, MAb MB; and D, MAb MN. Reprinted with permission fromClin. Cancer Res. 11(16):5840-6.
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MSLN / Mesothelin Mouse anti-Human Monoclonal (MB-G10) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$485
MSLN / Mesothelin Antibody - Anti-MSLN / Mesothelin antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.
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MSLN / Mesothelin Mouse anti-Human Monoclonal (MN-1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
MSLN / Mesothelin Antibody
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MSLN / Mesothelin Rat anti-Mouse Monoclonal (B35) Antibody
Mouse
Flo
Unconjugated
100 µg/$415
MSLN / Mesothelin Antibody - Mesothelin antibody IHC-paraffin. IHC(P): Mouse Lung Tissue.
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MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (aa308-576) Antibody
Mouse
IHC, IHC-P
Unconjugated
100 µg/$397
MSLN / Mesothelin Antibody - Immunodetection Analysis: Representative blot from a previous lot. Lane 1, recombinant protein MSLN. The membrane blot was probed with antiMSLN primary antibody (1µg/ml). Proteins were visualized using a Donkey Anti-Rabbit secondary antibody conjugated to IRDye 800CW detection system. Arrows indicate cellular MSLN from human and mouse cells (34 kDa).
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MSLN / Mesothelin Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$231; 100 µg/$293; 200 µg/$324; 500 µg/$442
MSLN / Mesothelin Antibody - MSLN / Mesothelin antibody Western blot of MCF7 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa540-589) Antibody
Mouse, Guinea pig, Bovine, Pig, Human
WB
Unconjugated
100 µl/$416
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$730
MSLN / Mesothelin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
34.9kD
10 µg/$253; 50 µg/$306; 500 µg/$810; 1 mg/$1,168
MSLN / Mesothelin Antibody - Western Blot; Sample: Recombinant protein.
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MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (aa345-548) Antibody
Mouse
WB
Unconjugated
100 µl/$302; 200 µl/$345; 500 µl/$489; 1 ml/$561
MSLN / Mesothelin ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
250 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$571
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MSLN / Mesothelin Rat anti-Human Monoclonal Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$747
MSLN / Mesothelin Antibody - Human Lung, Mesothelium: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa 37-598) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
MSLN / Mesothelin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
MSLN / Mesothelin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$821
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MSLN / Mesothelin Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IP, WB
Biotin Conjugated
100 µl/$734
MSLN / Mesothelin Antibody - MSLN / Mesothelin antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa395-444) Antibody
Human
WB
Unconjugated
100 µl/$396
MSLN / Mesothelin Protein
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HEK 293 Cells
Human IgG1 Fc, N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human MSLN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 545 amino acids and has a predicted molecular mass of 60.7 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.
100 µg/$431; 50 µg/$338
MSLN / Mesothelin Protein
Select
E. coli
6His, N-terminus
33 kDa
10 µg/$255; 50 µg/$305; 100 µg/$355
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Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
61kD
10 µg/$267; 50 µg/$376; 500 µg/$1,439; 1 mg/$2,055
Select
HEK 293 Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
60.7 kDa
50 µg/$473; 100 µg/$677
MSLN / Mesothelin Antibody - Western blot analysis of extracts of various cell lines.
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MSLN / Mesothelin Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
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MSLN / Mesothelin Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$284; 100 µg/$351
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MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated
50 µg/$284; 100 µg/$351
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MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
50 µg/$284; 100 µg/$351
Viewing 1-25 of 186 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).