Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

CSF1R / CD115 / FMS

colony stimulating factor 1 receptor

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.

Gene Name: colony stimulating factor 1 receptor
Family/Subfamily: Protein Kinase , PDGF Receptor
Synonyms: CSF1R, CD115 antigen, CSF-1R, CSF-1-R, CSF-1 receptor, FMS, Fim-2, FIM2, FMS proto-oncogene, M-CSFR, HDLS, M-cfs receptor, C-FMS, CD115, CSF1 receptor, CSFR, M-CSF-R, MCSF Receptor, Proto-oncogene c-Fms
Target Sequences: NM_005211 NP_005202.2 P07333

Publications (6)

1
Selective depletion of cultured macrophages by magnetite nanoparticles modified with gelatin. Komohara Y, Kawauchi R, Makiyama E, Mikami K, Horlad H, Fujiwara Y, Kida T, Takeya M, Niidome T. Experimental and therapeutic medicine. 2017 14:1640-1646. (WB; Human) [Full Text Article] [PubMed:28810630] [PMC:PMC5526123]
2
Colony-Stimulating Factor-1 Receptor Is Required for Nurse-like Cell Survival in Chronic Lymphocytic Leukemia. Avery Polk, Ye Lu, Tianjiao Wang, Erlene Seymour, Nathanael G Bailey, Jack W Singer, Philip S Boonstra, Megan S Lim, Sami Malek, Ryan A Wilcox. Clinical cancer research : an official journal of the American Association for Cancer Research. 2016 December;22:6118-6128. [Full Text Article] [PubMed:27334834] [PMC:PMC5161678]
3
Interleukin-34, a Novel Paracrine/Autocrine Factor in Mouse Testis, and Its Possible Role in the Development of Spermatogonial Cells In Vitro. Alaa Sawaied, Eitan Lunenfeld, Mahmoud Huleihel. International journal of molecular sciences. 2020 October;21: [Full Text Article] [PubMed:33143373] [PMC:PMC7662511] Related Antibodies: LS-C164350.
4
Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear. Jinsei Jung, Jee Eun Yoo, Young Ho Choe, Sang Chul Park, Hyun Jae Lee, Hack June Lee, Byunghwa Noh, Sung Huhn Kim, Gyeong-Yi Kang, Kang-Mu Lee, Sang Sun Yoon, Dong Su Jang, Joo-Heon Yoon, Young-Min Hyun, Jae Young Choi. Cell host & microbe. 2019 Apr;25:513-525e6. [Full Text Article] [PubMed:30905438] Related Antibodies: LS-C164350.
5
Tumor necrosis factor-inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor-driven model of rheumatoid arthritis. Binder NB, Puchner A, Niederreiter B, Hayer S, Leiss H, Bl[Character fc]ml S, Kreindl R, Smolen JS, Redlich K. Arthritis and rheumatism. 2013 Mar;65:608-17. [Full Text Article] [PubMed:23280418] Related Antibodies: LS-C117866.
6
Gene silencing of Tead3 abrogates radiation-induced adaptive response in cultured mouse limb bud cells. Vares G, Wang B, Tanaka K, Shang Y, Taki K, Nakajima T, Nenoi M. Journal of radiation research. 2011 52:39-46. [Full Text Article] [PubMed:21293071] Related Antibodies: LS-C8599.
more

☰ Filters
Antibodies (159)
Proteins (41)
ELISA Kits (19)
Cell-Based (1)
Cell-Based Phosphorylation (2)
Custom (3)
Over-Expression Lysate (2)
Primary (159)
Recombinant (39)
Sandwich (13)
CSF1R / CD115 / FMS (219)
Human (113)
Mouse (90)
Rat (53)
Bat (2)
Bovine (4)
Cat (4)
Chicken (4)
Dog (3)
Hamster (1)
Horse (3)
Monkey (4)
Pig (5)
Porcine (1)
Rabbit (1)
Sheep (2)
Zebrafish (2)
IHC (50)
IHC-Fr (1)
IHC-P (21)
WB (120)
Flo (28)
Bind (5)
Block (1)
Depl (1)
ELISA (80)
Func (3)
ICC (8)
IF (21)
IP (1)
Neut (1)
Peptide-ELISA (13)
SDS-PAGE (11)
rabbit (131)
mouse (15)
goat (2)
rat (10)
sheep (1)
Product Group
IHCPlus (2)
IgG (84)
IgG1 (5)
IgG1,k (2)
IgG2a (3)
IgG2a,k (6)
IgG2b (4)
monoclonal mc (25)
polyclonal pc (134)
1486CT328.53.37 (1)
1G4 (1)
460615 (1)
4C9G2 (1)
604B5 2E11 (2)
6B9B9 (1)
6B9H2 (1)
AFS98 (6)
ROS8G11 (3)
ROS-AV170 (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (6)
96-Well Strip Plate (12)
AP Conjugated (3)
APC (3)
APC Conjugated (11)
Azide-free (4)
Biotin Conjugated (8)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (10)
HRP Conjugated (8)
Low Endotoxin (1)
PE Conjugated (8)
Preservative Free (4)
RPE Conjugated (1)
Unconjugated (104)
aa639-868 (8)
aa734-900 (8)
aa768-928 (8)
aa895-923 (8)
aa940-971 (8)
pTyr809 (7)
750-830 aa (4)
C-Terminus (3)
pTyr561 (3)
pTyr723 (3)
500-580 aa (2)
640-720 aa (2)
660-740 aa (2)
Extracellular Domain (2)
aa344-497 (2)
aa781-830 (2)
p809 (2)
pTyr699 (2)
pTyr708 (2)
650-730 aa (1)
Ab-561 (1)
Ab-699 (1)
Asn805 (1)
Gln718 (1)
Glu557 (1)
Internal (1)
Tyr699 (1)
Tyr708 (1)
Tyr723 (1)
Tyr923 (1)
aa20-511 (1)
aa531-580 (1)
aa669-718 (1)
aa691-740 (1)
aa700-710 (1)
aa734-744 (1)
aa955-972 (1)
p723 (1)
No (216)
Yes (3)
Adherent Cell Cultures (3)
Cell Culture Supernatants (4)
Cell Lysates (1)
Plasma (9)
Serum (9)
Tissue Homogenates (3)
6His, C-terminus (4)
DDK (Flag)-His, C-terminus (1)
DDK,C-terminus (1)
Fc, C-terminus (4)
Fc/His,C-terminus (1)
GST, N-terminus (1)
His (5)
His,C-terminus (5)
His-Fc (1)
His-GST (2)
His-GST, N-terminus (2)
His-SUMO (1)
Human IgG Fc, C-terminus (2)
Human IgG1 Fc (1)
Human IgG1 Fc, C-terminus (2)
Human IgG1 Fc-His, C-terminus (1)
Mouse IgG2a Fc, C-terminus (1)
Myc-DDK (Flag) (3)
Cat (1)
Crab-eating macaque (2)
Human (26)
Mouse (8)
Rat (3)
293T Cells (1)
Baculovirus (4)
E. coli (4)
HEK 293 Cells (21)
Human Cells (4)
Insect Cells (1)
Mammalian Cells (4)
Sf9 Cells (1)
Wheat Germ Extract (1)
Purified (6)
Low endotoxin level (30)
Biologically active (11)
CSF1R / CD115 / FMS Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CSFR Antibody. The picture on the right is blocked with the synthesized peptide.
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (aa531-580) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$306; 100 µl/$366
CSF1R / CD115 / FMS Antibody - Mouse Csf1r Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse cerebellum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
CSF1R / CD115 / FMS Rabbit anti-Mouse Polyclonal (aa895-923) Antibody
Mouse, Rat
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
400 µl/$376
CSF1R / CD115 / FMS Antibody - IHC of paraffin-embedded pancreas tissues using CSF1R mouse monoclonal antibody with DAB staining.
Select
CSF1R / CD115 / FMS Mouse anti-Human Monoclonal (aa344-497) (6B9B9) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$415
CSF1R / CD115 / FMS Antibody - IHC of paraffin-embedded prostate cancer tissues using CSF1R mouse monoclonal antibody with DAB staining.
Select
CSF1R / CD115 / FMS Mouse anti-Human Monoclonal (aa344-497) (6B9H2) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$415
CSF1R / CD115 / FMS Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using M-CSF Receptor Antibody. The picture on the right is blocked with the synthesized peptide.
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (aa691-740) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
CSF1R / CD115 / FMS Antibody - Immunofluorescent analysis of CD115 staining in COLO205 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 ??C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Rat, Human, Monkey
ICC, IF, WB
Unconjugated
30 µl/$245; 100 µl/$289; 200 µl/$341
CSF1R / CD115 / FMS Antibody - Immunohistochemical analysis of CD115 staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Zebrafish, Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$245; 100 µl/$289; 200 µl/$341
CSF1R / CD115 / FMS ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$721
CSF1R / CD115 / FMS ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (pTyr723) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µl/$611
CSF1R / CD115 / FMS ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$571
Select
CSF1R / CD115 / FMS Sheep anti-Mouse Polyclonal (Extracellular Domain) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
100 µg/$806
Select
CSF1R / CD115 / FMS Mouse anti-Human Monoclonal (Extracellular Domain) (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$762
CSF1R / CD115 / FMS Protein - Human CSF1R / CD115 / CD6, human recombinant
Select
HEK 293 Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
55.1 kDa, DTT-reduced protein migrates as 80-95 kDa polypeptide in SDS-PAGE.
100 µg/$867; 20 µg/$372
CSF1R / CD115 / FMS Antibody - CSF1R monoclonal antibody (M01), clone 1G4. Western Blot analysis of CSF1R expression in human colon.
Select
CSF1R / CD115 / FMS Mouse anti-Human Monoclonal (1G4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$407
CSF1R / CD115 / FMS Antibody - HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human CSF1R with C-terminal MYC tag probed with (0.5ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed (1mg/ml) in Lane B. Primar
Select
CSF1R / CD115 / FMS Goat anti-Human Polyclonal (aa700-710) Antibody
Mouse, Dog, Rat, Hamster, Horse, Bat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$451
CSF1R / CD115 / FMS Antibody - HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human CSF1R with C-terminal MYC tag probed with (1ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed (1mg/ml) in Lane B. Primary
Select
CSF1R / CD115 / FMS Goat anti-Human Polyclonal (aa734-744) Antibody
Dog, Bovine, Pig, Horse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$451
Select
CSF1R / CD115 / FMS Rat anti-Mouse Monoclonal (aa20-511) (APC) Antibody
Mouse
Flo
APC Conjugated
100 Tests/$747
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (pTyr809) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$611
CSF1R / CD115 / FMS Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (aa768-928) Antibody
Human
ICC, IHC-P, IP, WB
Unconjugated
50 µl/$460
CSF1R / CD115 / FMS Antibody - WB of CSF1R / CD115 / FMS antibody. WB: Rat Intestines Tissue Lysate.
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (aa955-972) Antibody
Sheep, Bovine, Horse, Bat, Human, Monkey
WB
Unconjugated
100 µg/$369
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, Flo, ICC, IF, WB
FITC Conjugated
200 µl/$767
CSF1R / CD115 / FMS Antibody - Western blot of recombinant CSF1R / CD115 / FMS.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CSF1R / CD115 / FMS Rabbit anti-Rat Polyclonal (aa734-900) Antibody
Rat
WB
Unconjugated
100 µl/$302; 200 µl/$346; 500 µl/$491; 1 ml/$563
CSF1R / CD115 / FMS Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using M-CSF Receptor (Phospho-Tyr723) Antibody. The picture on the right is blocked with the phospho peptide.
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (pTyr723) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
Select
CSF1R / CD115 / FMS Rabbit anti-Human Polyclonal (660-740 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
Viewing 1-25 of 219 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).