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ITGA4 / VLA-4 / CD49d

integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.

Gene Name: integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGA4, 269C wild type, CD49D, IA4, Integrin alpha-4, Integrin alpha 4, Integrin alpha-4 subunit, Integrin alpha-IV, VLA-4, VLA-4 subunit alpha, CD49d antigen
Target Sequences: NM_000885 NP_000876.3 P13612

Publications (6)

1
CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells. Kleinewietfeld M, Starke M, Di Mitri D, Borsellino G, Battistini L, Rtzschke O, Falk K. Blood. 2009 113:827-36. [PubMed:18941119] Related Antibodies: LS-C40971.
2
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease. Palacios F, Moreno P, Morande P, Abreu C, Correa A, Porro V, Landoni AI, Gabus R, Giordano M, Dighiero G, Pritsch O, Oppezzo P. Blood. 2010 115:4488-96. [PubMed:20233972] Related Antibodies: LS-C40971.
3
Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells. Mattapallil MJ, Silver PB, Mattapallil JJ, Horai R, Karabekian Z, McDowell JH, Chan CC, James EA, Kwok WW, Sen HN, Nussenblatt RB, David CS, Caspi RR. Journal of immunology (Baltimore, Md. : 1950). 2011 187:1977-85. [PubMed:21765017] [PMC:PMC3150271] Related Antibodies: LS-C40971.
4
Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth. Beauvais DM, Jung O, Yang Y, Sanderson RD, Rapraeger AC. Cancer research. 2016 76:4981-93. (IP; Human) [Full Text Article] [PubMed:27364558] [PMC:PMC5010496]
5
Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours. Pulkka OP, Mpindi JP, Tynninen O, Nilsson B, Kallioniemi O, Sihto H, Joensuu H. Journal of cellular and molecular medicine. 2018 April;22:2220-2230. (Human) [Full Text Article] [PubMed:29377440] [PMC:PMC5867167] Related Antibodies: LS-A9385.
6
Renal denervation and CD161a immune ablation prevent cholinergic hypertension and renal sodium retention. Nandita Raikwar, Cameron Braverman, Peter M Snyder, Robert A Fenton, David K Meyerholz, Francois M Abboud, Sailesh C Harwani. American journal of physiology. Heart and circulatory physiology. 2019 September;317:H517-H530. [Full Text Article] [PubMed:31172810] [PMC:PMC6766722] Related Antibodies: LS-C192282.
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☰ Filters
Antibodies (169)
ELISA Kits (6)
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Primary (169)
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ITGA4 / VLA-4 / CD49d (179)
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ITGA4 / VLA-4 / CD49d Antibody - Anti-VLA-4 / CD49D antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10-20 ug/ml.
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ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
ITGA4 / VLA-4 / CD49d Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Rat, Hamster, Pig, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
ITGA4 / VLA-4 / CD49d Antibody - Anti-ITGA4 / Integrin Alpha 4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
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ITGA4 / VLA-4 / CD49d Rat anti-Mouse Monoclonal (Azide-free, Low Endotoxin) (PS/2) Antibody
Mouse, Human
Flo, IHC, IHC-Fr, Inhb
Unconjugated, Azide-free, Low Endotoxin
0.5 mg/$381
Select
ITGA4 / VLA-4 / CD49d Rat anti-Mouse Monoclonal (Low Endotoxin) (PS/2) Antibody
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated, Low Endotoxin
0.5 mg/$627
Select
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Rat, Hamster, Mouse, Human
ELISA, IHC, IP, RIA, WB
Unconjugated
100 µl/$725
ITGA4 / VLA-4 / CD49d Antibody - Western blot analysis of CD49d expression in HEK293T (A); Raw264.7 (B); H9C2 (C) whole cell lysates.
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ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$289
ITGA4 / VLA-4 / CD49d Antibody - Human peripheral blood lymphocytes stained with purified 9F10, followed by anti-mouse IgGs FITC
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ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (9F10) Antibody
Dog, Sheep, Bovine, Cat, Horse, Human, Monkey, Baboon
Flo, IHC, IHC-Fr
Unconjugated
25 µg/$230; 100 µg/$256
ITGA4 / VLA-4 / CD49d Antibody - Anti-ITGA4 / Integrin Alpha 4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
ITGA4 / VLA-4 / CD49d Antibody - Western blot of Integrin alpha 4 pAb in extracts from Jurkat cells.
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ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$433
ITGA4 / VLA-4 / CD49d Antibody - Immunofluorescence of Integrin alpha 4 in Jurkat cells with Integrin alpha 4 antibody at 2 ug/ml.
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ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
0.1 mg/$420
Select
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal Antibody
Bovine, Rat, Pig, Cynomolgus, Human, Monkey
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$547; 200 µg/$742
Select
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$547; 200 µg/$780
ITGA4 / VLA-4 / CD49d Antibody - Immunohistochemistry of paraffin-embedded human spleen tissue at dilution of 1:100
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ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$284; 100 µg/$348
Select
ITGA4 / VLA-4 / CD49d Rat anti-Mouse Monoclonal Antibody
Mouse, Human
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$547; 250 µg/$742
Select
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (HP2/1) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$363
ITGA4 / VLA-4 / CD49d Antibody - Integrin alpha 4 antibody IHC-paraffin. IHC(P): Human Mammary Cancer Tissue.
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ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (aa999-1028) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$421
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ITGA4 / VLA-4 / CD49d Rat anti-Mouse Monoclonal (Biotin) (PS/2) Antibody
Mouse
Flo, IHC, IP
Biotin Conjugated
500 µg/$485
ITGA4 / VLA-4 / CD49d Antibody - Flow cytometry of ITGA4  /  VLA-4 / CD49d antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (FITC) (BU49) Antibody
Human
Flo, Func, IHC
FITC Conjugated
120 Tests/$411
Select
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (FITC) (9F10) Antibody
Cat, Cow, Horse, Dog, Sheep, Human, Non-Human Primates
Flo, Func, IHC-Fr
FITC Conjugated
100 Tests/$327
Select
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IHC, IP, RIA
Unconjugated
100 µg/$745
Select
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, Flo, ICC, IHC, IP, RIA, WB
Biotin Conjugated
100 µl/$848
Select
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, Flo, ICC, IHC, IP, RIA, WB
APC Conjugated
100 µl/$848
Select
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, Flo, ICC, IHC, IP, RIA, WB
PE Conjugated
100 µl/$848
Select
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IHC, IP, RIA
Unconjugated
100 µg/$745
Viewing 1-25 of 179 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).