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IGF1R / IGF1 Receptor

insulin-like growth factor 1 receptor

Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Gene Name: insulin-like growth factor 1 receptor
Family/Subfamily: Protein Kinase , Insulin receptor
Synonyms: IGF1R, CD221 antigen, CD221, IGF1 Receptor, IGFR, IGF-I receptor, Soluble IGF1R variant 1, Soluble IGF1R variant 2, Type 1 IGF receptor, IGFIR, JTK13
Target Sequences: NM_000875 NP_000866.1 P08069

☰ Filters
Antibodies (185)
ELISA Kits (25)
Proteins (17)
Cell-Based (1)
Cell-Based Phosphorylation (2)
Custom (3)
Over-Expression Lysate (4)
Primary (185)
Recombinant (13)
Sandwich (18)
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IGF1R / IGF1 Receptor (227)
Human (191)
Mouse (75)
Rat (65)
Bat (4)
Bovine (12)
Chicken (11)
Chimpanzee (3)
Dog (6)
Gibbon (3)
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Orangutan (3)
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IHC (73)
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rabbit (122)
mouse (62)
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monoclonal mc (62)
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12 (2)
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aa763-955 (8)
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1100-1180 aa (6)
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1280-1360 aa (2)
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IGF1R / IGF1 Receptor Antibody - Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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IGF1R / IGF1 Receptor Mouse anti-Human Monoclonal (1H7) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
IGF1R / IGF1 Receptor Antibody - Anti-IGF1 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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IGF1R / IGF1 Receptor Mouse anti-Human Monoclonal (RPE) (1H7) Antibody
Human
Flo
RPE Conjugated
100 Tests/$456
IGF1R / IGF1 Receptor Antibody - Anti-IGF1 Receptor antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroscience
Cancer Pathology
IGF1R / IGF1 Receptor Mouse anti-Human Monoclonal (aa1264-1367) (JBW902) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$565
IGF1R / IGF1 Receptor Antibody - Anti-IGF1 Receptor antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (aa1126-1175) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
IGF1R / IGF1 Receptor Antibody - Immunohistochemistry: IGF1 Receptor Antibody - Analysis of IGF1R in human kidney carcinoma using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Primate, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$376
IGF1R / IGF1 Receptor Antibody - IHC of paraffin-embedded human breast tumor section, showing membrane and cytoplasmic staining, using Insulin-Like Growth Factor I Receptor, beta (IGF1Rb).
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$580
IGF1R / IGF1 Receptor Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using IGF1R (Phospho-Tyr1161) Antibody. The picture on the right is blocked with the phospho peptide.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (pTyr1161) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, Peptide-ELISA, WB
Unconjugated
50 µl/$318; 100 µl/$378
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IGF1R / IGF1 Receptor Mouse anti-Human Monoclonal (Azide-free) (24-31) Antibody
Rabbit, Human
ELISA, IP
Unconjugated, Azide-free
100 µl/$771; 200 µl/$937
IGF1R / IGF1 Receptor Antibody - Immunohistochemical analysis of IGF1 Receptor (pY1161) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (pTyr1161) Antibody
Chicken, Zebrafish, Bovine, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$253; 100 µl/$305; 200 µl/$369
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IGF1R / IGF1 Receptor Goat anti-Human Polyclonal Antibody
Human
IHC, Neut, WB
Unconjugated
100 µg/$819
IGF1R / IGF1 Receptor Antibody - IHC of paraffin-embedded ovarian cancer tissues using IGF1R-Beta mouse monoclonal antibody with DAB staining.
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IGF1R / IGF1 Receptor Mouse anti-Human Monoclonal (3G5C1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$404
IGF1R / IGF1 Receptor Antibody - Immunohistochemistry: IGF1 Receptor Antibody - Analysis of IGF1R in human kidney carcinoma using DAB with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Primate, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$376
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IGF1R / IGF1 Receptor Mouse anti-Human Monoclonal (1B1) Antibody
Human
Flo, IF, IP, WB
Unconjugated
100 µg/$574
IGF1R / IGF1 Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$809
IGF1R / IGF1 Receptor Antibody - IGF1R Antibody (N-term K66) IHC of formalin-fixed and paraffin-embedded brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of the IGF1R Antibody (N-term K66) for immunohistochemistry.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (aa51-77) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$376
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IGF1R / IGF1 Receptor Mouse anti-Human Monoclonal (17-69) Antibody
Rabbit, Pig, Human
IP
Unconjugated
0.1 ml/$319; 0.5 ml/$544; 1 ml/$823
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IGF1R / IGF1 Receptor Mouse anti-Human Monoclonal (24-60) Antibody
Rabbit, Pig, Human
IP
Unconjugated
100 µl/$356; 500 µl/$696; 1 ml/$908
IGF1R / IGF1 Receptor Antibody - 1:200 staining rat lung tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (pTyr1165,pTyr1166) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
IGF1R / IGF1 Receptor Antibody - Western blot analysis of IGF1 Receptor (pY1165/Y1166) expression in HEK293T (A); MCF7 (B) whole cell lysates.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (pTyr1165/Tyr1166) Antibody
Chicken, Zebrafish, Bovine, Mouse, Rat, Human
WB
Unconjugated
100 µl/$305
IGF1R / IGF1 Receptor Antibody - Western blot analysis of IGF1 Receptor expression in HEK293T (A); SP2/0 (B); NIH3T3 (C) whole cell lysates.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Zebrafish, Bovine, Mouse, Rat, Human
WB
Unconjugated
100 µl/$289
IGF1R / IGF1 Receptor ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$721
IGF1R / IGF1 Receptor Protein - Recombinant Insulin Like Growth Factor 1 Receptor (IGF1R) by SDS-PAGE
Select
E. coli
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
25.7kDa
10 µg/$268; 50 µg/$403; 200 µg/$803; 100 µg/$641; 1 mg/$1,814; 500 µg/$1,350; 5 mg/$3,902
IGF1R / IGF1 Receptor Antibody - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (pTyr1161) Antibody
IF, IHC, WB
Unconjugated
20 µl/$253; 50 µl/$306; 100 µl/$381; 200 µl/$489
IGF1R / IGF1 Receptor Antibody - IGF1R / IGF1 Receptor antibody. IHC(P): Rat Pancreatic Gland Tissue.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (aa1353-1367) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$421
IGF1R / IGF1 Receptor Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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IGF1R / IGF1 Receptor Rabbit anti-Human Polyclonal (aa19-51) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$381
Viewing 1-25 of 227 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).