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MAP4K1 / HPK1

mitogen-activated protein kinase kinase kinase kinase 1

HPK1, a KHS protein kinase, is an upstream activator of the stress-activated protein kinase (SAPK) signaling pathway. The protein has a structure similar to other GCK (Group I) kinases and contains four consensus SH3 binding motifs, which have been shown to interact with the SH3 motifs of the MAP kinase kinase kinases MLK3 and MEKK1 and several adapter proteins that couple to tyrosine kinases, including BASH, Blnk, Clnk, Crk, CrkL and Grb2. Additionally, HPK1 has been shown to be phosphorylated and activated by the tyrosine kinase c-Abl in response to genotoxic agents. At least two mRNA transcripts have been reported.

Gene Name: mitogen-activated protein kinase kinase kinase kinase 1
Family/Subfamily: Protein Kinase , KHS
Synonyms: MAP4K1, HPK1, MEKKK 1, MEK kinase kinase 1, MHPK1
Target Sequences: NM_007181 NP_009112.1 Q92918

☰ Filters
Antibodies (40)
Proteins (5)
ELISA Kits (3)
Over-Expression Lysate (2)
Primary (40)
Recombinant (3)
Sandwich (3)
MAP4K1 / HPK1 (48)
Human (42)
Mouse (18)
Rat (7)
Bat (4)
Bovine (4)
Chimpanzee (6)
Dog (8)
Gibbon (6)
Guinea pig (4)
Horse (4)
Monkey (4)
Orangutan (3)
Pig (8)
IHC (11)
IHC-P (3)
WB (32)
DB (7)
ELISA (22)
IF (1)
IP (2)
Peptide-ELISA (3)
rabbit (39)
goat (1)
Product Group
IHCPlus (2)
Ig (3)
IgG (30)
polyclonal pc (40)
96-Well Strip Plate (2)
AP Conjugated (3)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (21)
aa321-350 (8)
pSer171 (7)
aa218-267 (4)
aa61-110 (4)
340-420 aa, Internal (1)
Leu397 (1)
Ser421 (1)
aa1-50 (1)
aa2-14 (1)
aa348-397 (1)
aa371-420 (1)
aa550-600 (1)
No (48)
Cell Lysates (1)
Plasma (2)
Serum (2)
Tissue Homogenates (1)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (5)
293T Cells (1)
HEK 293 Cells (1)
Insect Cells (1)
Wheat Germ Extract (2)
Purified (1)
Biologically active (1)
MAP4K1 / HPK1 Antibody - Anti-MAP4K1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Select
MAP4K1 / HPK1 Goat anti-Human Polyclonal (aa2-14) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$440
MAP4K1 / HPK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
MAP4K1 / HPK1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
MAP4K1 / HPK1 Antibody - Western blot of HPK1 (L397) pAb in extracts from HepG2 cells.
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MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (Leu397) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$394
MAP4K1 / HPK1 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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MAP4K1 / HPK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$642
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$825
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$825
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$825
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
200 µl/$825
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$825
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$825
MAP4K1 / HPK1 Antibody - All lanes: Anti-MAP4K1 (Y381) Antibody at 1:2000 dilution Lane 1: Jurkat whole cell lysate Lane 2: Raji whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 91 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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MAP4K1 / HPK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
200 µl/$376
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (pSer171) (PE) Antibody
Human
DB, ELISA
PE Conjugated
200 µl/$832
MAP4K1 / HPK1 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa218-267) Antibody
Rat, Pig, Horse, Bat, Mouse, Dog, Human
WB
Unconjugated
100 µl/$414
MAP4K1 / HPK1 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa218-267) (FITC) Antibody
Mouse, Dog, Rat, Pig, Horse, Bat, Gibbon, Chimpanzee, Human
WB
FITC Conjugated
100 µl/$459
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa550-600) Antibody
Human
IP
Unconjugated
100 µl/$483
MAP4K1 / HPK1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$485
MAP4K1 / HPK1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$376
MAP4K1 / HPK1 Antibody - Western blot of HPK1 antibody
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (340-420 aa, Internal) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
MAP4K1 / HPK1 Antibody - Western blot of Human Fetal Muscle. MAP4K1 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa61-110) Antibody
Mouse, Dog, Guinea pig, Bovine, Pig, Human, Monkey
WB
Unconjugated
100 µl/$414
MAP4K1 / HPK1 Antibody - Western blot of Human Fetal Muscle. MAP4K1 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa61-110) (FITC) Antibody
Mouse, Dog, Guinea pig, Bovine, Pig, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$459
MAP4K1 / HPK1 Protein - 12.5% SDS-PAGE of human MAP4K1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
118.58 kDa
2 µg/$429
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
Select
MAP4K1 / HPK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
Viewing 1-25 of 48 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).