Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

DGCR8

DGCR8 microprocessor complex subunit

Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Involved in the silencing of embryonic stem cells self-renewal.

Gene Name: DGCR8 microprocessor complex subunit
Synonyms: DGCR8, DGCRK6, Gy1, C22orf12, Pasha
Target Sequences: NM_022720 NP_073557.3 Q8WYQ5

☰ Filters
Antibodies (38)
Proteins (5)
Over-Expression Lysate (2)
Primary (38)
Recombinant (3)
DGCR8 (43)
Human (38)
Mouse (15)
Rat (8)
Bat (1)
Bovine (5)
Chicken (1)
Chimpanzee (3)
Dog (5)
Gibbon (3)
Guinea pig (4)
Hamster (1)
Monkey (5)
Pig (5)
Rabbit (1)
Xenopus (1)
IHC (9)
IHC-P (5)
WB (35)
Flo (2)
ELISA (14)
IF (2)
IP (3)
Peptide-ELISA (1)
rabbit (34)
mouse (3)
goat (1)
Product Group
IHCPlus (1)
IgG (28)
IgG1 (1)
IgG2b,k (1)
monoclonal mc (2)
polyclonal pc (36)
4G3 (1)
AP Conjugated (2)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Preservative Free (1)
Unconjugated (20)
aa439-466 (8)
Internal (4)
aa180-229 (4)
aa1-50 (2)
aa400-450 (1)
aa446-460 (1)
pSer377 (1)
No (43)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
DGCR8 Antibody - Western blot analysis of extracts of various cell lines, using DGCR8 antibody.
Select
DGCR8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated
50 µl/$306; 100 µl/$381
DGCR8 Antibody - IHC analysis of DGCR8 using anti-DGCR8 antibody. DGCR8 was detected in paraffin-embedded section of mouse small intestine tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-DGCR8 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Select
DGCR8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$421
DGCR8 Antibody - Anti-DGCR8 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
DGCR8 Rabbit anti-Human Polyclonal (aa180-229) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$485
DGCR8 Antibody - Anti-DGCR8 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
DGCR8 Rabbit anti-Human Polyclonal (aa180-229) (HRP) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$459
DGCR8 Antibody - Anti-DGCR8 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
DGCR8 Rabbit anti-Human Polyclonal (aa180-229) (Biotin) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$459
DGCR8 Antibody - Anti-DGCR8 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
DGCR8 Rabbit anti-Human Polyclonal (aa180-229) (FITC) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$459
DGCR8 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Select
DGCR8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
DGCR8 Antibody - Detection of Human DGCR8 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-DGCR8 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
Select
DGCR8 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IP, WB
Unconjugated
100 µl/$483
Select
DGCR8 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
DGCR8 Antibody - Detection limit for recombinant GST tagged DGCR8 is 0.1 ng/ml as a capture antibody.
Select
DGCR8 Mouse anti-Human Monoclonal (4G3) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$413
DGCR8 Antibody - Western blot of DGCR8 Antibody in NCI-H460 cell line lysates (35 ug/lane). DGCR8 (arrow) was detected using the purified antibody.
Select
DGCR8 Rabbit anti-Human Polyclonal (aa439-466) Antibody
Human
Flo, WB
Unconjugated
400 µl/$376
DGCR8 Antibody - Detection of Human DGCR8 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-DGCR8 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
Select
DGCR8 Rabbit anti-Human Polyclonal (aa400-450) Antibody
Human
IHC, IP
Unconjugated
100 µl/$483
Select
DGCR8 Rabbit anti-Human Polyclonal (aa439-466) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$642
Select
DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$825
Select
DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$825
Select
DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (AP) Antibody
Human
ELISA, WB
AP Conjugated
200 µl/$825
Select
DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$825
Select
DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$825
Select
DGCR8 Rabbit anti-Human Polyclonal (aa439-466) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$825
Select
DGCR8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
Select
DGCR8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$321
DGCR8 Antibody
Select
DGCR8 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, WB
Unconjugated
100 µl/$317
DGCR8 Antibody - Detection of Human DGCR8 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-DGCR8 used at a dilution of 1:250.
Select
DGCR8 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC
Unconjugated
100 µl/$500
Select
DGCR8 Rabbit anti-Mouse Polyclonal (pSer377) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$438
Select
DGCR8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µg/$636
Viewing 1-25 of 43 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).