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IL21 Receptor

Interleukin 21 Receptor

IL21 Receptor is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Gene Name: Interleukin 21 Receptor
Family/Subfamily: Interleukin
Synonyms: IL21R, CD360, Interleukin 21 receptor, Interleukin-21 receptor, NILR, IL-21 receptor, CD360 antigen, IL-21R, IL21 Receptor, Novel interleukin receptor
Target Sequences: NM_021798 NP_068570.1 Q9HBE5

Publications (1)

1
Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model. Keating JJ, Runge JJ, Singhal S, Nims S, Venegas O, Durham AC, Swain G, Nie S, Low PS, Holt DE. Cancer. 2017 May;123:1051-1060. [Full Text Article] [PubMed:28263385] [PMC:PMC5341137] Related Antibodies: LS-B572.

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Products
Proteins (19)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (7)
Recombinant (11)
IL21 Receptor (19)
No (19)
6His, C-terminus (2)
6His, N-terminus (2)
GST (1)
His (2)
His, C-Terminal (1)
His, N-Terminal (1)
His,C-terminus (1)
His-S (1)
Human IgG1 Fc (1)
Mouse Mutant IgG2a Fc (1)
Myc-DDK (Flag) (6)
Human (12)
Mouse (3)
Rat (1)
293T Cells (3)
CHO Cells (2)
E. coli (1)
HEK 293 Cells (6)
Human (1)
Human Cells (3)
Mammalian Cells (2)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (8)
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Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
25.7kD
10 µg/$248; 50 µg/$321; 500 µg/$725; 1 mg/$1,021
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26kD
10 µg/$243; 50 µg/$288; 500 µg/$785; 1 mg/$1,021
IL21 Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
57 kDa
20 µg/$215
IL21 Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
57 kDa
20 µg/$150
IL21 Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
57 kDa
20 µg/$215
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26.5 kDa
100 µg/$483
IL21 Receptor Protein - 12.5% SDS-PAGE of human IL21R stained with Coomassie Blue
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Wheat Germ Extract
GST
84.92 kDa
2 µg/$439
IL21 Receptor Protein - Recombinant  Interleukin 21 Receptor By SDS-PAGE
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E. coli
His-S
22.5 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
Select
HEK 293 Cells
6His, N-terminus
25 kDa
200 µl/$283
Select
HEK 293 Cells
6His, N-terminus
25 kDa
100 µg/$298
IL21 Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
57 kDa
100 µg/$494
IL21 Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
57 kDa
100 µg/$710
IL21 Receptor Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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HEK 293 Cells
His, N-Terminal
~35-45 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432
IL21 Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
57 kDa
100 µg/$710
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.0 kDa
10 µg/$244; 50 µg/$288
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.7 kDa
10 µg/$248; 50 µg/$317
Select
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$456
Select
CHO Cells
Mouse Mutant IgG2a Fc
Less than 0.06 EU/µg protein (determined by LAL method).
25 µg/$337
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26.5 kDa
100 µg/$721
Viewing 1-19 of 19 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).