MUC4

mucin 4, cell surface associated

May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

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Products

Antibodies (26)

Type

Primary (26)

Target

MUC4 (26)

Reactivity

Human (26)

Mouse (8)

Rat (9)

Application

IHC (6)

IHC-Fr (3)

IHC-P (3)

WB (23)

ELISA (9)

Peptide-ELISA (1)

Host

rabbit (17)

mouse (9)

Isotype

IgG (4)

IgG1 (8)

IgG2a,k (1)

Clonality

monoclonal mc (10)

polyclonal pc (16)

Clone

1G8 (1)

5B12 (1)

8G7 (2)

EP256 (1)

Format

APC (1)

APC Conjugated (2)

Biotin Conjugated (2)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Ready-to-Use (1)

Unconjugated (14)

Epitope

aa1154-1309 (8)

C-Terminus (1)

aa1249-1444 (1)

aa529-560 (1)

Publications

No (26)

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MUC4 Antibody (clone 5B12) LS-C104999

Antibody:

MUC4 Mouse anti-Human Monoclonal (5B12) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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MUC4 Antibody (clone 8G7) LS-C743525

Antibody:

MUC4 Mouse anti-Human Monoclonal (8G7) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$316

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MUC4 Antibody (clone 8G7, Ready-to-Use) LS-C743418

Antibody:

MUC4 Mouse anti-Human Monoclonal (Ready-to-Use) (8G7) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated, Ready-to-Use

Price:

3 ml/$325

• Unconjugated
• Unconjugated, Ready-to-Use

• Unconjugated
• Unconjugated, Ready-to-Use

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MUC4 Antibody (clone EP256) LS-C743556

Antibody:

MUC4 Rabbit anti-Human Monoclonal (EP256) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$321; 0.5 ml/$620; 1 ml/$899

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MUC4 Antibody (HRP) LS-C548124

Antibody:

MUC4 Mouse anti-Rat Monoclonal (HRP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

100 µl/$1,017

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MUC4 Antibody (Biotin) LS-C528023

Antibody:

MUC4 Mouse anti-Rat Monoclonal (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,017

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MUC4 Antibody (FITC) LS-C537984

Antibody:

MUC4 Mouse anti-Rat Monoclonal (FITC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$1,017

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MUC4 Antibody (APC) LS-C518202

Antibody:

MUC4 Mouse anti-Rat Monoclonal (APC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

100 µl/$1,017

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MUC4 Antibody (PE) LS-C656154

Antibody:

MUC4 Mouse anti-Rat Monoclonal (PE) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

100 µl/$1,017

• HRP
• Biotin
• FITC
• APC
• PE

• HRP
• Biotin
• FITC
• More...
  • APC
  • PE

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MUC4 Antibody LS-C666962

Antibody:

MUC4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

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MUC4 Antibody LS-C780736

Antibody:

MUC4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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MUC4 Antibody LS-C808074

Antibody:

MUC4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MUC4 Antibody LS-C340994

Antibody:

MUC4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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MUC4 Antibody (aa1154-1309) LS-C295444

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa1154-1309) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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MUC4 Antibody (aa1154-1309, HRP) LS-C708894

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa1154-1309) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511

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MUC4 Antibody (aa1154-1309, Biotin) LS-C300967

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa1154-1309) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279

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MUC4 Antibody (aa1154-1309, FITC) LS-C691840

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa1154-1309) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$341; 200 µl/$397; 500 µl/$583; 1 ml/$715; 2 ml/$953; 5 ml/$1,628

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MUC4 Antibody (aa1154-1309, APC) LS-C739349

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa1154-1309) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

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MUC4 Antibody (aa1154-1309, APC, Cy7) LS-C731952

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa1154-1309) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$489; 200 µl/$614; 500 µl/$1,108; 1 ml/$1,329; 2 ml/$1,860; 5 ml/$3,487

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MUC4 Antibody (aa1154-1309, Cy3) LS-C699871

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa1154-1309) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

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MUC4 Antibody (aa1154-1309, PE) LS-C722954

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa1154-1309) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• APC, Cy7
• Cy3
• More...
  • PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • APC, Cy7
  • Cy3
  • PE

Select

MUC4 Antibody (aa1249-1444) LS-C344004

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa1249-1444) Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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MUC4 Antibody (aa529-560) LS-C344406

Antibody:

MUC4 Rabbit anti-Human Polyclonal (aa529-560) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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MUC4 Antibody (C-Terminus) LS-C353754

Antibody:

MUC4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

Select

MUC4 Antibody LS-C783513

Antibody:

MUC4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

25 µg/$281; 100 µg/$400

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