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CPSF3 / CPSF

cleavage and polyadenylation specific factor 3, 73kDa

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.

Gene Name: cleavage and polyadenylation specific factor 3, 73kDa
Synonyms: CPSF3, CPSF 73 kDa subunit, CPSF-73, CPSF73, CPSF, YSH1
Target Sequences: NM_016207 NP_057291.1 Q9UKF6

☰ Filters
Antibodies (30)
cDNAs (30)
Proteins (5)
cDNA Clone (2)
Expression-Ready ORF Clone (28)
Over-Expression Lysate (2)
Primary (30)
Recombinant (3)
CPSF3 / CPSF (65)
Human (30)
Mouse (9)
Rat (9)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (6)
Dog (4)
Gibbon (6)
Guinea pig (4)
Horse (4)
Monkey (8)
Orangutan (6)
Pig (4)
Rabbit (8)
Xenopus (4)
Zebrafish (4)
IHC (7)
IHC-P (7)
WB (29)
ELISA (9)
IF (1)
IP (1)
rabbit (28)
mouse (2)
Product Group
IHCPlus (2)
IgG (28)
IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (29)
1H8 (1)
AP Conjugated (2)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (12)
aa192-221 (8)
C-Terminus (4)
aa189-238 (4)
aa634-684 (2)
aa1-50 (1)
No (65)
DDK (Flag), C-terminus (2)
DDK (Flag), N-terminus (2)
GFP, C-terminus (4)
GFP, N-terminus (2)
GST (1)
GST, N-terminus (1)
HA, C-terminus (2)
HA, N-terminus (2)
His, C-terminus (2)
His, N-terminus (2)
Myc, C-terminus (2)
Myc, N-terminus (2)
Myc-DDK (Flag) (3)
OFP, C-terminus (2)
OFP, N-terminus (2)
Untagged (4)
Human (15)
Mouse (15)
Lentiviral (2)
Mammalian (26)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
CPSF3 / CPSF Antibody - CPSF3 monoclonal antibody (M06), clone 1H8. Western blot of CPSF3 expression in PC-12.
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CPSF3 / CPSF Mouse anti-Human Monoclonal (1H8) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$407
CPSF3 / CPSF Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa189-238) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
100 µl/$355
CPSF3 / CPSF Antibody - Anti-CPSF3 / CPSF antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa634-684) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
50 µl/$485
CPSF3 / CPSF Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CPSF3 / CPSF Antibody - Detection of Human and Mouse CPSF73 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-CPSF73 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa634-684) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$457
CPSF3 / CPSF Antibody - CPSF3 antibody ARP40841_T100-NP_057291-CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CPSF3 / CPSF Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$355
CPSF3 / CPSF Antibody - CPSF3 antibody ARP40841_T100-NP_057291-CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CPSF3 / CPSF Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Rat, Rabbit, Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$380
CPSF3 / CPSF Antibody - CPSF3 antibody ARP40841_T100-NP_057291-CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Rat, Rabbit, Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$380
CPSF3 / CPSF Antibody - CPSF3 antibody ARP40841_T100-NP_057291-CPSF3 (cleavage and polyadenylation specific factor 3, 73kDa) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Rat, Rabbit, Human, Monkey, Chimpanzee, Orangutan, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$380
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa192-221) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$614
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa192-221) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$767
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa192-221) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$767
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa192-221) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$767
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa192-221) (AP) Antibody
Human
ELISA, WB
AP Conjugated
200 µl/$767
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa192-221) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$767
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa192-221) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$767
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$396
Select
CPSF3 / CPSF Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$582
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$622
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$774
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (AP) Antibody
Human
WB
AP Conjugated
100 µl/$774
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$774
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$774
CPSF3 / CPSF Antibody - CPSF3 Antibody western blot of A375 cell line lysates (35 ug/lane). The CPSF3 antibody detected the CPSF3 protein (arrow).
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal (aa192-221) Antibody
Human
WB
Unconjugated
400 µl/$376
CPSF3 / CPSF Antibody - Western blot analysis of extracts of various cell lines, using CPSF3 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.
Select
CPSF3 / CPSF Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
Viewing 1-25 of 65 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).