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PIAS4 / PIASY

protein inhibitor of activated STAT, 4

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Gene Name: protein inhibitor of activated STAT, 4
Synonyms: PIAS4, E3 SUMO-protein ligase PIAS4, PIAS-gamma, ZMIZ6, Piasg, PIASY
Target Sequences: NM_015897 NP_056981.2 Q8N2W9

Publications (3)

1
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7R surface expression. McLeod IX, Zhou X, Li QJ, Wang F, He YW. Journal of immunology (Baltimore, Md. : 1950). 2011 187:5051-61. [PubMed:22021616] [PMC:PMC3248807] Related Antibodies: LS-C98800.
2
Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. Conn KL, Wasson P, McFarlane S, Tong L, Brown JR, Grant KG, Domingues P, Boutell C. Journal of virology. 2016 90:4807-26. (ICC, WB; Human) [Full Text Article] [PubMed:26937035] [PMC:PMC4836348] Related Antibodies: LS-C108719.
3
SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. Brown JR, Conn KL, Wasson P, Charman M, Tong L, Grant K, McFarlane S, Boutell C. Journal of virology. 2016 90:5939-52. (ICC, WB; Human) [Full Text Article] [PubMed:27099310] [PMC:PMC4907222] Related Antibodies: LS-C108719.

☰ Filters
Antibodies (43)
Proteins (4)
ELISA Kits (1)
Cell-Based (1)
Over-Expression Lysate (2)
Primary (43)
Recombinant (2)
PIAS4 / PIASY (48)
Human (44)
Mouse (23)
Rat (7)
Bat (5)
Bovine (6)
Chicken (5)
Chimpanzee (3)
Dog (4)
Guinea pig (5)
Hamster (4)
Horse (5)
Monkey (6)
Pig (5)
Sheep (1)
Xenopus (4)
Zebrafish (4)
IHC (24)
IHC-P (5)
WB (43)
ELISA (27)
ICC (1)
IF (1)
Peptide-ELISA (1)
rabbit (43)
Product Group
IHCPlus (1)
IgG (35)
polyclonal pc (43)
96-Well Microplate (1)
AP Conjugated (3)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (22)
aa44-73 (8)
aa471-499 (8)
aa48-79 (8)
N-Terminus (4)
420-500 aa, C-terminal (1)
Asp488 (1)
C-Terminus (1)
aa295-310 (1)
aa44-60 (1)
aa451-500 (1)
No (46)
Yes (2)
Adherent Cell Cultures (1)
GST (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
PIAS4 / PIASY Antibody - Immunohistochemistry of PIAS4 in rat brain tissue with PIAS4 antibody at 5 µg/mL.
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$420
PIAS4 / PIASY Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$381
PIAS4 / PIASY Antibody - Anti-PIAS4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa451-500) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$505
PIAS4 / PIASY Antibody - Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Mouse, Dog, Guinea pig, Rat, Hamster, Human, Monkey
WB
Unconjugated
100 µl/$434
PIAS4 / PIASY Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (420-500 aa, C-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$614
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$614
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa48-79) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$767
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$347
PIAS4 / PIASY Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (aa471-499) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$376
PIAS4 / PIASY Antibody - Immunohistochemical analysis of PIAS4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$289
PIAS4 / PIASY Antibody - IHC of PIAS4 (D488) pAb in paraffin-embedded human lung carcinoma tissue.
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal (Asp488) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$319; 100 µl/$393
PIAS4 / PIASY Antibody - Western blot of PIAS4 expression in Jurkat cell extract
Select
PIAS4 / PIASY Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$295; 100 µg/$347
Viewing 1-25 of 48 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).