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SENP6

SUMO1/sentrin specific peptidase 6

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).

Gene Name: SUMO1/sentrin specific peptidase 6
Family/Subfamily: Protease , Cysteine C48
Synonyms: SENP6, KIAA0797, Protease fksg6, Sentrin-specific protease 6, SUMO-1 protease-1, SUMO-1-specific protease 1, SUSP1, SSP1
Target Sequences: NM_015571 NP_056386.2 Q9GZR1

☰ Filters
Antibodies (52)
Proteins (3)
Over-Expression Lysate (2)
Primary (52)
Recombinant (1)
SENP6 (55)
Human (52)
Mouse (7)
Rat (7)
Bat (5)
Bovine (9)
Chicken (5)
Chimpanzee (6)
Dog (5)
Gibbon (3)
Hamster (1)
Horse (9)
Monkey (5)
Orangutan (3)
Pig (4)
Rabbit (5)
IHC (37)
IHC-P (5)
WB (21)
ELISA (36)
ICC (6)
IF (8)
Peptide-ELISA (3)
rabbit (49)
mouse (1)
goat (2)
Product Group
IHCPlus (1)
IgG (40)
IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (51)
4B7 (1)
AP Conjugated (4)
APC Conjugated (4)
Azide-free (4)
Biotin Conjugated (7)
FITC Conjugated (7)
HRP Conjugated (7)
PE Conjugated (4)
Unconjugated (19)
N-Terminus (14)
C-Terminus (12)
aa1081-1112 (8)
aa788-837 (4)
1010-1090 aa, C-terminal (1)
Lys1077 (1)
aa1042-1091 (1)
aa2-14 (1)
aa778-790 (1)
No (55)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
SENP6 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SENP6 Rabbit anti-Human Polyclonal (aa1081-1112) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$515
SENP6 Antibody - Immunohistochemical analysis of SENP6 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
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SENP6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$289
SENP6 Antibody - SENP6 antibody Western Blot of Mouse Lung.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SENP6 Rabbit anti-Mouse Polyclonal (aa788-837) Antibody
Chicken, Bovine, Rat, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
WB
Unconjugated
100 µl/$434
SENP6 Antibody - Immunoperoxidase of monoclonal antibody to SENP6 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml]
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SENP6 Mouse anti-Human Monoclonal (4B7) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$407
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SENP6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IF, IHC
Unconjugated
200 µl/$614
Select
SENP6 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
ELISA, ICC, IF, IHC
Biotin Conjugated
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
ELISA, ICC, IF, IHC
FITC Conjugated
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (C-Terminus) (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, IHC
HRP Conjugated, Azide-free
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (C-Terminus) (APC) Antibody
Human
ELISA, ICC, IF, IHC
APC Conjugated
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (C-Terminus) (AP) Antibody
Human
ELISA, ICC, IF, IHC
AP Conjugated
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (C-Terminus) (PE) Antibody
Human
ELISA, ICC, IF, IHC
PE Conjugated
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (aa1081-1112) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$614
Select
SENP6 Rabbit anti-Human Polyclonal (aa1081-1112) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (aa1081-1112) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (aa1081-1112) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (aa1081-1112) (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (aa1081-1112) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$767
Select
SENP6 Rabbit anti-Human Polyclonal (aa1081-1112) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$767
SENP6 Antibody - 1:100 staining human Testis tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SENP6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
Select
SENP6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$614
Select
SENP6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$614
Select
SENP6 Rabbit anti-Human Polyclonal (1010-1090 aa, C-terminal) Antibody
Human
ELISA, IHC
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
SENP6 Antibody - Immunofluorescent analysis of Hela cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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SENP6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$284; 100 µg/$351
SENP6 Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using SENP6 Antibody. The picture on the right is blocked with the synthesized peptide.
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SENP6 Rabbit anti-Human Polyclonal (aa1042-1091) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$306; 100 µl/$366
SENP6 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SENP6 antibody.
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SENP6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$347
Viewing 1-25 of 55 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).