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ACKR2 / CCR10 / D6

atypical chemokine receptor 2

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.

Gene Name: atypical chemokine receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: ACKR2, C-C chemokine receptor D6, CCBP2, Chemokine (C-C) receptor 9, Chemokine binding protein 2, C-C chemokine receptor 10, Chemokine-binding protein 2, CMKBR9, Chemokine receptor CCR-9, G protein coupled receptor d6, HD6, Cc-chemokine receptor type 10, Chemokine receptor CCR-10, Chemokine receptor D6, Chemokine-binding protein D6, D6
Target Sequences: NM_001296 NP_001287.2 O00590

☰ Filters
Antibodies (47)
Proteins (5)
ELISA Kits (3)
Custom (2)
Over-Expression Lysate (2)
Primary (47)
Recombinant (3)
Sandwich (1)
ACKR2 / CCR10 / D6 (55)
Human (46)
Mouse (15)
Rat (1)
Gibbon (3)
IHC (37)
IHC-P (22)
WB (29)
Flo (1)
ELISA (27)
ICC (14)
IF (8)
IP (7)
Peptide-ELISA (3)
rabbit (45)
mouse (1)
goat (1)
Product Group
GPCR Database Antibodies (14)
IHCPlus (13)
PathPlus Neuro (2)
IgG (29)
polyclonal pc (47)
96-Well Strip Plate (3)
AP Conjugated (4)
APC Conjugated (4)
Azide-free (4)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (4)
Unconjugated (20)
N-Terminus (11)
aa298-328 (8)
aa54-84 (8)
Internal (7)
310-390 aa, C-terminal (2)
aa335-384 (2)
Ser383 (1)
aa334-383 (1)
No (55)
Plasma (1)
Serum (1)
GST (2)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
ACKR2 / CCR10 / D6 Antibody - Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 24 ug/ml.
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Neuroscience
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
ACKR2 / CCR10 / D6 Antibody - Anti-ACKR2 / CCR10 / D6 antibody IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa335-384) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$505
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$396
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ACKR2 / CCR10 / D6 Mouse anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$582
ACKR2 / CCR10 / D6 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa298-328) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$376
ACKR2 / CCR10 / D6 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa54-84) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$376
ACKR2 / CCR10 / D6 Antibody - Western blot of Chemokine Receptor D6 antibody
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (310-390 aa, C-terminal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
ACKR2 / CCR10 / D6 Antibody - Brain, Medulla
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Neuroscience
Fast Shipping
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
ACKR2 / CCR10 / D6 Antibody - Brain, Medulla
Select
Fast Shipping
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody
Human
IHC, IHC-P
PE Conjugated
100 µl/$650
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa54-84) Antibody
ICC, IHC, IP, WB
Unconjugated
200 µl/$614
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa54-84) (Biotin) Antibody
Mouse, Human
ELISA, ICC, IHC, IP, WB
Biotin Conjugated
200 µl/$767
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa54-84) (FITC) Antibody
Mouse, Human
ELISA, ICC, IHC, IP, WB
FITC Conjugated
200 µl/$767
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa54-84) (AP) Antibody
Mouse, Human
ELISA, ICC, IHC, IP, WB
AP Conjugated
200 µl/$767
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa54-84) (PE) Antibody
Mouse, Human
ELISA, ICC, IHC, IP, WB
PE Conjugated
200 µl/$767
Select
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa54-84) (APC) Antibody
Mouse, Human
ELISA, ICC, IHC, IP, WB
APC Conjugated
200 µl/$767
Select
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa54-84) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, ICC, IHC, IP, WB
HRP Conjugated, Azide-free
200 µl/$767
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa298-328) (Biotin) Antibody
Mouse, Human
ELISA, ICC, IHC, WB
Biotin Conjugated
200 µl/$767
Select
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa298-328) (FITC) Antibody
Mouse, Human
ELISA, ICC, IHC, WB
FITC Conjugated
200 µl/$767
Select
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa298-328) (APC) Antibody
Mouse, Human
ELISA, ICC, IHC, WB
APC Conjugated
200 µl/$767
Select
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa298-328) (AP) Antibody
Mouse, Human
ELISA, ICC, IHC, WB
AP Conjugated
200 µl/$767
Select
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa298-328) (PE) Antibody
Mouse, Human
ELISA, ICC, IHC, WB
PE Conjugated
200 µl/$767
Select
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (aa298-328) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, ICC, IHC, WB
HRP Conjugated, Azide-free
200 µl/$767
ACKR2 / CCR10 / D6 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
ACKR2 / CCR10 / D6 Antibody - Peptide - + Immunofluorescence analysis of COS-7 cells, using CCBP2 antibody.
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µl/$347
ACKR2 / CCR10 / D6 Antibody - Western blot of Chemokine Receptor D6 (S383) pAb in extracts from HepG2.
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ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (Ser383) Antibody
Human
IF, IHC, WB
Unconjugated
50 µl/$319; 100 µl/$393
Viewing 1-25 of 55 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).