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CD95 / FAS

Fas cell surface death receptor

CD95 / FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Gene Name: Fas cell surface death receptor
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: FAS, ALPS1A, APO-1, APT1, Apo-1 antigen, APO-1 cell surface antigen, Apo11 antigen, Apoptosis antigen 1, CD95 antigen, Delta Fas/APO-1/CD95, Fas AMA, FAS1, Fasl receptors, FASLG receptor, FASTM, FAS 827dupA, Fasl receptor, TNFRSF6, CD95
Target Sequences: NM_152877 NP_000034.1 P25445

Publications (2)

1
Combined evaluation of the FAS cell surface death receptor and CD8+ tumor infiltrating lymphocytes as a prognostic biomarker in breast cancer. Blok EJ, van den Bulk J, Dekker-Ensink NG, Derr R, Kanters C, Bastiaannet E, Kroep JR, van de Velde CJ, Kuppen PJ. Oncotarget. 2017 8:15610-15620. (Flo; Human) [Full Text Article] [PubMed:28121628] [PMC:PMC5362509] Related Antibodies: LS-B2820.
2
Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata. Chang JS, Kuo HP, Chang KL, Kong ZL. PloS one. 2015 10:e0136782. (IHC; Human) [Full Text Article] [PubMed:26327534] Related Antibodies: LS-C179869.

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CD95 / FAS Antibody - Anti-FAS antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CD95 / FAS Mouse anti-Human Monoclonal (LT95) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
0.05 mg/$440
CD95 / FAS Antibody - Surface staining of human peripheral blood cells with anti-CD95 (LT95) PE.
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CD95 / FAS Mouse anti-Human Monoclonal (PE) (LT95) Antibody
Human
Flo, IHC-P
PE Conjugated
100 Tests/$355
CD95 / FAS Antibody - Anti-FAS antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CD95 / FAS Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$555
CD95 / FAS Antibody - Anti-FAS antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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CD95 / FAS Goat anti-Human Polyclonal (aa224-237) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$585
CD95 / FAS Antibody - Induction of apoptosis in various hematopoetic cell lines by use of anti-Fas antibodies.  Suspensions of used cell lines were incubated with soluble (or without as control) anti-Fas antibodies. Induction of apoptosis was measured by Apoptosis Assay Kit - FITC.  Histograms:  Red (full) – untreated control cells  Black – standard apoptosis-inducing anti-Fas antibody  Green – anti-Fas (UT-1)    A – JURKAT human peripheral blood T cell leukemia cell line  B – TF-1 human bone marrow erythroleukemia cell line  C – CEM human leukemia cell line  D – MOLT-4 human acute lymphoblastic T cell leukemia cell line
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CD95 / FAS Mouse anti-Human Monoclonal (Azide-free) (UT-1) Antibody
Human
Flo
Unconjugated, Azide-free
0.1 mg/$327
CD95 / FAS Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CD95 / FAS Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Mouse, Rat
IF, IHC-P, WB
Unconjugated
50 µg/$440
CD95 / FAS Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD95 / FAS Mouse anti-Human Monoclonal (PE) (UB2) Antibody
Human
Flo, IHC
PE Conjugated
50 Tests/$431
CD95 / FAS Antibody
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CD95 / FAS Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$358; 200 µg/$498
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CD95 / FAS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$278; 120 µl/$338; 200 µl/$440
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CD95 / FAS Mouse anti-Human Monoclonal (CH11) Antibody
Human
Flo, ICC, WB
Unconjugated
50 µg/$817
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CD95 / FAS Rabbit anti-Rat Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat
IP
Magnetic beads Conjugated
100 µg/$363
CD95 / FAS Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
CD95 / FAS Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
CD95 / FAS Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CD95 / FAS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µl/$460
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CD95 / FAS Rat anti-Mouse Monoclonal (Biotin) Antibody
Mouse, Bovine
IP, WB
Biotin Conjugated
100 µl/$837
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CD95 / FAS Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IHC, IHC-Fr
Unconjugated
100 µg/$625
CD95 / FAS Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CD95 / FAS Rabbit anti-Human Polyclonal (aa281-330) Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$505
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.6 kDa
5 µg/$252; 20 µg/$325
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CD95 / FAS Mouse anti-Human Monoclonal (APO-1-3) Antibody
Human
Flo, Func, IP, WB
Unconjugated
50 µg/$334
Select
CD95 / FAS Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IHC, IHC-Fr, IP
FITC Conjugated
100 Tests/$517
Select
CD95 / FAS Mouse anti-Human Monoclonal (PE, Cy5) Antibody
Human
Flo, IHC, IHC-Fr, IP
PE, Cy5 Conjugated
100 Tests/$554
CD95 / FAS Antibody - Western blot of FAS antibody
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CD95 / FAS Rabbit anti-Human Polyclonal (230-310 aa) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
Select
CD95 / FAS Rabbit anti-Rat Polyclonal (aa87-109) Antibody
Rat
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$614
CD95 / FAS Antibody
Select
CD95 / FAS Mouse anti-Human Monoclonal (UB2) Antibody
Human
Flo, IHC
Unconjugated
100 µg/$446
CD95 / FAS Antibody
Select
CD95 / FAS Rat anti-Mouse Monoclonal (RMF6) Antibody
Mouse
Flo
Unconjugated
100 µg/$399
CD95 / FAS Antibody - FAS Antibody in Immunofluorescence (IF)
Select
CD95 / FAS Mouse anti-Human Monoclonal (4F8H6) Antibody
Human
Flo, ICC, IF, WB
Unconjugated
100 µg/$460
Viewing 1-25 of 462 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).