Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

SIK1 / MSK

salt-inducible kinase 1

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1.

Gene Name: salt-inducible kinase 1
Family/Subfamily: Protein Kinase , AMPK/SNF1
Synonyms: SIK1, KID2, Salt-inducible kinase, Salt-inducible kinase 1, Salt-inducible protein kinase, SIK, MSK, SIK-1, SNF1-like kinase, Myocardial SNF1-like kinase, QIK, Qin-induced kinase, SNF1LK
Target Sequences: NM_173354 NP_775490.2 P57059

Publications (1)

1
The Effects of Low-Dose and High-Dose Decoctions of Fructus aurantii in a Rat Model of Functional Dyspepsia. Jing Zhu, Hengli Tong, Xide Ye, Jinlian Zhang, Yi Huang, Ming Yang, Lingyun Zhong, Qianfeng Gong. Medical science monitor : international medical journal of experimental and clinical research. 2020 April;26:e919815. [Full Text Article] [PubMed:32248203] [PMC:PMC7156881]

☰ Filters
Antibodies (43)
cDNAs (15)
Proteins (5)
ELISA Kits (4)
cDNA Clone (1)
Custom (2)
Expression-Ready ORF Clone (14)
Over-Expression Lysate (2)
Primary (43)
Recombinant (3)
Sandwich (2)
SIK1 / MSK (67)
Human (39)
Mouse (23)
Rat (10)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (8)
Monkey (4)
Xenopus (4)
IHC (18)
IHC-P (8)
WB (38)
ELISA (26)
IF (6)
Peptide-ELISA (1)
rabbit (42)
mouse (1)
Product Group
IHCPlus (4)
IgG (36)
IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (42)
2C12 (1)
96-Well Strip Plate (4)
AP Conjugated (3)
APC Conjugated (3)
Azide-free (2)
Biotin Conjugated (6)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (3)
Unconjugated (16)
aa567-597 (8)
aa573-600 (8)
N-Terminus (4)
aa551-600 (4)
120-200 aa (1)
aa148-197 (1)
p182 (1)
No (66)
Yes (1)
Plasma (2)
Serum (2)
Tissue Homogenates (1)
DDK (Flag), C-terminus (1)
DDK (Flag), N-terminus (1)
GFP, C-terminus (2)
GFP, N-terminus (1)
GST (1)
GST, N-terminus (1)
HA, C-terminus (1)
HA, N-terminus (1)
His, C-terminus (1)
His, N-terminus (1)
Myc, C-terminus (1)
Myc, N-terminus (1)
Myc-DDK (Flag) (2)
OFP, C-terminus (1)
OFP, N-terminus (1)
Untagged (2)
Human (15)
Lentiviral (1)
Mammalian (13)
Human (4)
293T Cells (1)
HEK 293 Cells (1)
Insect Cells (1)
Wheat Germ Extract (2)
Purified (1)
Biologically active (1)
SIK1 / MSK Antibody - Anti-SIK1 / MSK antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa567-597) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$515
SIK1 / MSK Antibody - SIK1 / SNF1LK antibody Western blot of Rat Lung lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIK1 / MSK Rabbit anti-Rat Polyclonal (aa551-600) Antibody
Chicken, Mouse, Dog, Guinea pig, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
100 µl/$434
SIK1 / MSK Antibody - Anti-SIK1 / SNF1LK antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
SIK1 / MSK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$545
SIK1 / MSK Antibody - Anti-SIK1 / SNF1LK antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
SIK1 / MSK Mouse anti-Human Monoclonal (2C12) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$545
SIK1 / MSK Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer using SIK1 Polyclonal Antibody at dilution of 1:40.
Select
SIK1 / MSK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$242; 60 µl/$278; 120 µl/$338; 200 µl/$440
SIK1 / MSK Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa148-197) Antibody
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$505
SIK1 / MSK Antibody - SIK1 / SNF1LK antibody SNF1LK(SNF1-like kinase) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human stomach.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Xenopus, Horse, Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$404
SIK1 / MSK Antibody - SIK1 / SNF1LK antibody SNF1LK(SNF1-like kinase) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human stomach.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Xenopus, Bovine, Horse, Human, Chimpanzee, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$429
SIK1 / MSK Antibody - SIK1 / SNF1LK antibody SNF1LK(SNF1-like kinase) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human stomach.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Bovine, Horse, Human, Chimpanzee, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$429
SIK1 / MSK Antibody - SIK1 / SNF1LK antibody SNF1LK(SNF1-like kinase) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human stomach.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Bovine, Horse, Human, Chimpanzee, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$429
SIK1 / MSK Antibody - Western blot of SIK1 antibody
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (120-200 aa) Antibody
Rat, Human
ELISA, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
IF, WB
Biotin Conjugated
100 µl/$774
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Human
IF, WB
PE Conjugated
100 µl/$774
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Human
IF, WB
APC Conjugated
100 µl/$774
SIK1 / MSK Antibody - Sik1 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The Sik1 antibody detected the Sik1 protein (arrow).
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa573-600) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$376
Select
SIK1 / MSK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$376
SIK1 / MSK Antibody - Immunohistochemistry of paraffin-embedded human lung cancer using SIK1 Antibody at dilution of 1:100
Select
SIK1 / MSK Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$284; 100 µg/$351
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa567-597) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$614
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa567-597) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$767
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa567-597) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$767
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa567-597) (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
200 µl/$767
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa567-597) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$767
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa567-597) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$767
Select
SIK1 / MSK Rabbit anti-Human Polyclonal (aa567-597) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$767
Select
SIK1 / MSK Rabbit anti-Mouse Polyclonal (aa573-600) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$614
Viewing 1-25 of 67 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).