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CELF1 / CUGBP1

CUGBP, Elav-like family member 1

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.

Gene Name: CUGBP, Elav-like family member 1
Synonyms: CELF1, Bruno-like protein 2, BRUNOL2, Bruno-like 2, CELF-1, CUG RNA-binding protein, CUGBP1, CUG-BP, EDEN-BP, HNab50, NAB50, NAPOR, RNA-binding protein BRUNOL-2, CUG-BP1, CUGBP, Deadenylation factor CUG-BP, EDEN-BP homolog
Target Sequences: NM_006560 NP_006551.1 Q92879

Publications (10)

1
A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. Good PJ, Chen Q, Warner SJ, Herring DC. The Journal of biological chemistry. 2000 275:28583-92. [PubMed:10893231]
2
Ribonuclear inclusions in skeletal muscle in myotonic dystrophy types 1 and 2. Mankodi A, Teng-Umnuay P, Krym M, Henderson D, Swanson M, Thornton CA. Annals of neurology. 2003 54:760-8. [PubMed:14681885]
3
Nuclear RNA foci in the heart in myotonic dystrophy. Mankodi A, Lin X, Blaxall BC, Swanson MS, Thornton CA. Circulation research. 2005 97:1152-5. (IHC) [PubMed:16254211]
4
Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy. Lin X, Miller JW, Mankodi A, Kanadia RN, Yuan Y, Moxley RT, Swanson MS, Thornton CA. Human molecular genetics. 2006 15:2087-97. (ICC, WB; Mouse, Human) [PubMed:16717059]
5
Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice. Kress C, Gautier-Courteille C, Osborne HB, Babinet C, Paillard L. Molecular and cellular biology. 2007 27:1146-57. [PubMed:17130239] [PMC:PMC1800704]
6
Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy. Orengo JP, Chambon P, Metzger D, Mosier DR, Snipes GJ, Cooper TA. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:2646-51. [PubMed:18272483] [PMC:PMC2268190]
7
Ectopic expression of CGG containing mRNA is neurotoxic in mammals. Hashem V, Galloway JN, Mori M, Willemsen R, Oostra BA, Paylor R, Nelson DL. Human molecular genetics. 2009 18:2443-51. [PubMed:19377084] [PMC:PMC2694692]
8
CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1. Ward AJ, Rimer M, Killian JM, Dowling JJ, Cooper TA. Human molecular genetics. 2010 19:3614-22. [PubMed:20603324] [PMC:PMC2928132]
9
Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia. Xiao Q, Ford AL, Xu J, Yan P, Lee KY, Gonzales E, West T, Holtzman DM, Lee JM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:13587-96. (ICC, IHC, WB, GS; Mouse, Rat) [PubMed:23015448] [PMC:PMC3482490]
10
The FMRP-MOV10 complex: a translational regulatory switch modulated by G-Quadruplexes. Phillip J Kenny, Miri Kim, Geena Skariah, Joshua Nielsen, Monica C Lannom, Stephanie Ceman. Nucleic acids research. 2019 Jan;48:862-878. [Full Text Article] [PubMed:31740951] [PMC:PMC7145700] Related Antibodies: LS-C408897.
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CELF1 / CUGBP1 (81)
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CELF1 / CUGBP1 Antibody - Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa120-169) Antibody
Xenopus, Chicken, Zebrafish, Horse, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$485
CELF1 / CUGBP1 Antibody - Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa120-169) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Rat, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$459
CELF1 / CUGBP1 Antibody - Anti-CELF1 / CUGBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa120-169) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Rat, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Chimpanzee, Orangutan
IHC, IHC-P, WB
FITC Conjugated
100 µl/$459
CELF1 / CUGBP1 Antibody - Western blot analysis of extracts of various cell lines.
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
CELF1 / CUGBP1 Antibody - Anti-CELF1 / CUGBP1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal (3B1) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
CELF1 / CUGBP1 Antibody - IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-CUGBP1 mouse monoclonal antibody. (Dilution 1:50).
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal (OTI5B8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
CELF1 / CUGBP1 Antibody - IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-CUGBP1 mouse monoclonal antibody. (Dilution 1:50).
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI5B8) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$473
CELF1 / CUGBP1 Antibody - Immunohistochemical analysis of CUGBP1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Zebrafish, Bovine, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$289
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$614
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$767
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$767
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$767
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa1-30) (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
200 µl/$767
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$767
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$767
CELF1 / CUGBP1 Antibody - Western blot of CUG-BP1 antibody
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (40-120 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
CELF1 / CUGBP1 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC, IP, WB
Unconjugated
200 µg/$673
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal (HRP) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC, IP, WB
HRP Conjugated
100 µl/$823
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal (Biotin) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC, IP, WB
Biotin Conjugated
100 µl/$823
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal (FITC) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC, IP, WB
FITC Conjugated
100 µl/$823
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal (PE) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC, IP, WB
PE Conjugated
100 µl/$823
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal (AP) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC, IP, WB
AP Conjugated
100 µl/$823
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CELF1 / CUGBP1 Mouse anti-Human Monoclonal (APC) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human
ICC, IP, WB
APC Conjugated
100 µl/$823
CELF1 / CUGBP1 Antibody - CUGBP1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human pancreas tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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CELF1 / CUGBP1 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$376
Viewing 1-25 of 81 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).