EIF4G1 / EIF4G is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
|Gene Name:||eukaryotic translation initiation factor 4 gamma, 1|
|Synonyms:||EIF4G1, EIF4-gamma, EIF-4-gamma 1, EIF-4G1, EIF4F, EIF4G, p220, PARK18, EIF-4G 1, EIF4GI|
|Target Sequences:||NM_004953 NP_004944.3 Q04637|
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