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A2M / Alpha-2-Macroglobulin

alpha-2-macroglobulin

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Gene Name: alpha-2-macroglobulin
Synonyms: A2M, CPAMD5, A2MD, FWP007, Alpha-2-M, Alpha-2-macroglobulin, S863-7
Target Sequences: NM_000014 NP_000005.2 P01023

☰ Filters
Antibodies (171)
ELISA Kits (28)
Proteins (18)
cDNAs (13)
cDNA Clone (1)
Competitive EIA (3)
Custom (2)
Development Kit (1)
Expression-Ready ORF Clone (12)
Native (2)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Primary (171)
Recombinant (12)
Sandwich (20)
Sandwich CLIA (2)
A2M / Alpha-2-Macroglobulin (230)
Human (106)
Mouse (35)
Rat (47)
Bovine (2)
Chicken (1)
Chimpanzee (3)
Dog (2)
Duck (3)
Gibbon (3)
Monkey (3)
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IHC (23)
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WB (140)
ELISA (61)
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ID (4)
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rabbit (111)
mouse (34)
goat (22)
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sheep (2)
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IgG1 (6)
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IgG2a,k (1)
IgG2b,k (19)
IgM (1)
monoclonal mc (34)
polyclonal pc (137)
2B5 (1)
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3127485 (1)
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590CT15.5.5 (1)
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A1 (8)
F1-P1C11 #3 (1)
F1-P1C11#3 (2N1/10) (1)
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aa818-1048 (10)
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A2M / Alpha-2-Macroglobulin Antibody - Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
A2M / Alpha-2-Macroglobulin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IE, IHC, IHC-P
Unconjugated
250 µg/$515
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$318
A2M / Alpha-2-Macroglobulin Antibody
Select
A2M / Alpha-2-Macroglobulin Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP
Unconjugated
100 µl/$341
A2M / Alpha-2-Macroglobulin Antibody - Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
A2M / Alpha-2-Macroglobulin Antibody - Anti-Alpha-2-Macroglobulin / A2M antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Rabbit, Dog, Pig, Human
ELISA, IE, IHC, IHC-P, IP
Unconjugated
0.5 mg/$440
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
625 - 40000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$574
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
3.7 - 300 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$602
A2M / Alpha-2-Macroglobulin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
A2M / Alpha-2-Macroglobulin Sheep anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
0.5 ml/$505
A2M / Alpha-2-Macroglobulin Antibody
Select
A2M / Alpha-2-Macroglobulin Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$341
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (HRP) Antibody
Rabbit, Dog, Pig, Human
ELISA, IE
HRP Conjugated
100 µg/$536
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (Biotin) Antibody
Human
ICC, WB
Biotin Conjugated
50 µg/$835
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$669
A2M / Alpha-2-Macroglobulin Antibody - Anti-A2M / Alpha-2-Macroglobulin antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$803
A2M / Alpha-2-Macroglobulin Antibody - Anti-A2M / Alpha-2-Macroglobulin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal (aa417-430) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
Select
A2M / Alpha-2-Macroglobulin Goat anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
10 ml/$458
A2M / Alpha-2-Macroglobulin Antibody - Western blot of recombinant Alpha-2-Macroglobulin / A2M.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Mouse Polyclonal (aa911-1042) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
200 µl/$351; 500 µl/$500; 1 ml/$577
A2M / Alpha-2-Macroglobulin Antibody - Immunohistochemistry of paraffin-embedded human endometrial cancer at dilution of 1:100
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$284; 100 µg/$351
A2M / Alpha-2-Macroglobulin Antibody - Western Blot; Sample: Recombinant a2M, Human.
Select
A2M / Alpha-2-Macroglobulin Mouse anti-Human Monoclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
200 µl/$333; 500 µl/$465; 1 ml/$531
A2M / Alpha-2-Macroglobulin Antibody - Immunohistochemistry of Macroglobulin alpha-2 antibody
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
Select
A2M / Alpha-2-Macroglobulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$376
A2M / Alpha-2-Macroglobulin Antibody - Western blot analysis of Alpha2-Macroglobulin antibody was performed by loading 5ul of Human Plasma and 5ul PageRuler Plus Prestained Protein Ladder onto a 4-20% Tris-Glycine polyacrylamide gel. Proteins were transferred to a nitrocellulose membrane using the G2 Fast Blotter and blocked with 5% milk in TBST for at least 1 hour at room temperature. Alpha 2 Macroglobulin was detected at ~180kD using an Alpha2-Macroglobulin monoclonal antibody at a concentration of 1 µg/mL in 5% milk in TBST overnight at 4C on a rocking platform, followed by an incubation with a goat anti-mouse IgG-HRP Superclonal secondary antibody at a dilution of 1:1000 for at least 1 hour. Chemiluminescent detection was performed using SuperSignal West Pico.
Select
A2M / Alpha-2-Macroglobulin Mouse anti-Human Monoclonal (F1-P1C11 #3) Antibody
Human
ELISA, IP, RIA, WB
Unconjugated
1000 µg/$776
A2M / Alpha-2-Macroglobulin Antibody - Clone PSA24 swine stomach, paraffin section
Select
A2M / Alpha-2-Macroglobulin Mouse anti-Porcine Monoclonal (PSA24) Antibody
Porcine
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$501
A2M / Alpha-2-Macroglobulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$653
Viewing 1-25 of 230 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).