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CXCL1 / GRO Alpha

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

GRO Alpha (CXCL1), a small cytokine belonging to the CXC chemokine family, secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. GRO alpha is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. GRO Alpha plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. An initial study in mice showed evidence that GRO alpha decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Gene Name: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Family/Subfamily: Intercrine , Intercrine alpha
Synonyms: CXCL1, C-X-C motif chemokine 1, Fibroblast secretory protein, FSP, GRO1, GROa, Growth-regulated alpha protein, GRO-alpha(1-73), MGSA, MGSA-a, Small inducible cytokine b1, GRO, MGSA alpha, NAP-3, SCYB1
Target Sequences: NM_001511 NP_001502.1 P09341

Publications (6)

1
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFa-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A. PloS one. 2015 10:e0119415. (IHC; Human) [Full Text Article] [PubMed:25785838] [PMC:PMC4364666] Related Antibodies: LS-C104351.
2
Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. Brochu ME, Girard S, Lavoie K, Sébire G. Journal of neuroinflammation. 2011 8:55. (WB; Rat) [Full Text Article] [PubMed:21599903]
3
3'-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. Kang LJ, Kwon ES, Lee KM, Cho C, Lee JI, Ryu YB, Youm TH, Jeon J, Cho MR, Jeong SY, Lee SR, Kim W, Yang S. British journal of pharmacology. 2018 December;175:4295-4309. [Full Text Article] [PubMed:30152858] [PMC:PMC6240131]
4
In vivo imaging reveals unique neutrophil transendothelial migration patterns in inflamed intestines. Sullivan DP, Bui T, Muller WA, Butin-Israeli V, Sumagin R. Mucosal immunology. 2018 November;11:1571-1581. [Full Text Article] [PubMed:30104624] [PMC:PMC6279495]
5
Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II-induced arthritis. Li ZY, Zhou JJ, Luo CL, Zhang LM. Molecular medicine reports. 2019 November;20:4540-4550. [Full Text Article] [PubMed:31702035] [PMC:PMC6797944]
6
Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury. Anna Piotrowska, Ewelina Rojewska, Katarzyna Pawlik, Grzegorz Kreiner, Agata Ciechanowska, Wioletta Makuch, Irena Nalepa, Joanna Mika. Frontiers in immunology. 2019 Sep;10:2198. [Full Text Article] [PubMed:31616413] [PMC:PMC6775284] Related Antibodies: LS-C104778.
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Antibodies (149)
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CXCL1 / GRO Alpha (238)
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CXCL1 / GRO Alpha Antibody - Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
CXCL1 / GRO Alpha Antibody - Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$325; 50 µg/$361
CXCL1 / GRO Alpha Antibody - Anti-GRO Alpha antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, Neut, WB
Unconjugated
0.1 mg/$485
CXCL1 / GRO Alpha Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$460
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CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (aa36-107) (7A11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$614
CXCL1 / GRO Alpha Antibody - Western blot of GRO / CXCL1 antibody.
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CXCL1 / GRO Alpha Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat
IHC, IP, WB
Unconjugated
100 µg/$471
CXCL1 / GRO Alpha Antibody - IHC of GRO (P88) pAb at 1:50 in paraffin-embedded human brain tissue.
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CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal (Pro88) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
100 µl/$394
CXCL1 / GRO Alpha Antibody - Detection limit for recombinant GST tagged CXCL1 is 1 ng/ml as a capture antibody.
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CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (2D7) Antibody
Human
ELISA
Unconjugated
100 µg/$413
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.614 - 150 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$537
CXCL1 / GRO Alpha Protein - Neutrophils chemoattracted by human CXCL1.
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E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 73 amino acid recombinant protein has a predicted molecular mass of approximately 7.8 kD. The DTT-reduced protein migrates at approximately 10 kD and non-reduced protein migrates at slightly higher than 10 kD by SDS-PAGE. The N-terminal amino acid is
10 µg/$262; 25 µg/$324; 100 µg/$602; 500 µg/$1,562
CXCL1 / GRO Alpha Antibody - Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CXCL1 / GRO Alpha Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
CXCL1 / GRO Alpha Antibody - Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CXCL1 / GRO Alpha Rabbit anti-Rat Polyclonal (Biotin) Antibody
Rat
ELISA, WB
Biotin Conjugated
25 µg/$325; 50 µg/$361
CXCL1 / GRO Alpha ELISA Kit
Select
Development Kit
200 Wells
Mouse
4 - 1000 pg/ml
Colorimetric - 405nm (ABTS)
1 Test/$180
CXCL1 / GRO Alpha ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
CXCL1 / GRO Alpha ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
CXCL1 / GRO Alpha Antibody - Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$325; 100 µg/$361
CXCL1 / GRO Alpha Antibody - Western Blot (non-reducing) of GRO / CXCL1 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
25 µg/$325; 50 µg/$361
CXCL1 / GRO Alpha Antibody - 1:100 staining human uterus tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
CXCL1 / GRO Alpha Antibody
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CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (aa36-107) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$425
Select
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$284; 100 µg/$348
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CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
50 µg/$284; 100 µg/$348
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CXCL1 / GRO Alpha Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, Neut, WB
HRP Conjugated
100 µl/$596
Select
CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$782
Select
CXCL1 / GRO Alpha Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$782
CXCL1 / GRO Alpha Antibody - Western blot of recombinant GRO / CXCL1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CXCL1 / GRO Alpha Rabbit anti-Mouse Polyclonal (aa25-96) Antibody
Mouse
WB
Unconjugated
100 µl/$282; 200 µl/$316; 500 µl/$431; 1 ml/$489
Viewing 1-25 of 238 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).