EPHA4 / EPH Receptor A4

EPH receptor A4

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

☰ Filters

Products

ELISA Kits (8)

Type

Custom (2)

Sandwich (6)

Target

EPHA4 / EPH Receptor A4 (8)

Reactivity

Human (4)

Mouse (2)

Rat (1)

Chicken (1)

Format

96-Well Strip Plate (6)

Publications

No (8)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (2)

EDTA Plasma (2)

Heparin Plasma (2)

Plasma (3)

Serum (5)

Tissue Homogenates (3)

Select

Human EPHA4 / EPH Receptor A4 (Sandwich ELISA) ELISA Kit - LS-F25447

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

Select

Human EPHA4 / EPH Receptor A4 (Sandwich ELISA) ELISA Kit - LS-F51842

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

25 - 1600 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

Select

Mouse EPHA4 / EPH Receptor A4 (Sandwich ELISA) ELISA Kit - LS-F57307

Type:

Sandwich

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Sample Types:

Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$1,150

Select

Rat EPHA4 / EPH Receptor A4 (Sandwich ELISA) ELISA Kit - LS-F57309

Type:

Sandwich

Reactivity:

Rat

Range:

31.2 - 2000 pg/ml

Sample Types:

Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum

Price:

1 Plate/$1,150

Select

Chicken EPHA4 / EPH Receptor A4 (Custom ELISA) ELISA Kit - LS-F14245

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

Select

Mouse EPHA4 / EPH Receptor A4 (Custom ELISA) ELISA Kit - LS-F14246

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human EPHA4 / EPH Receptor A4 (Sandwich ELISA) ELISA Kit - LS-F32942

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 mIU/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human EPHA4 / EPH Receptor A4 (Sandwich ELISA) ELISA Kit - LS-F11379

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 U/l

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Viewing 1-8 of 8 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: ELISA Kits

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.