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EP300 / p300

E1A binding protein p300

Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity.

Gene Name: E1A binding protein p300
Synonyms: EP300, E1A binding protein p300, Histone acetyltransferase p300, KAT3B, p300 HAT, E1A-associated protein p300, E1A-binding protein, 300kD, p300, RSTS2
Target Sequences: NM_001429 NP_001420.2 Q09472

Publications (5)

1
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Eckner R, Ewen ME, Newsome D, Gerdes M, DeCaprio JA, Lawrence JB, Livingston DM. Genes & development. 1994 8:869-84. [PubMed:7523245]
2
Association of p300 and CBP with simian virus 40 large T antigen. Eckner R, Ludlow JW, Lill NL, Oldread E, Arany Z, Modjtahedi N, DeCaprio JA, Livingston DM, Morgan JA. Molecular and cellular biology. 1996 16:3454-64. [PubMed:8668161] [PMC:PMC231340]
3
Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Eckner R, Yao TP, Oldread E, Livingston DM. Genes & development. 1996 10:2478-90. [PubMed:8843199]
4
Polyomavirus large T antigen binds the transcriptional coactivator protein p300. Nemethova M, Wintersberger E. Journal of virology. 1999 73:1734-9. [PubMed:9882390] [PMC:PMC104009]
5
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM. Genes & development. 1999 13:64-75. [PubMed:9887100] [PMC:PMC316375]
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EP300 / p300 (123)
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Human (5)
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EP300 / p300 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
EP300 / p300 Mouse anti-Human Monoclonal (aa1572-2371) (RW128) Antibody
Mouse, Rat, Mustelid, Primate, Human
IF, IHC-P, IP, WB
Unconjugated
0.1 mg/$460
EP300 / p300 Antibody - Anti-EP300 / p300 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EP300 / p300 Mouse anti-Human Monoclonal (aa1572-2371) (Biotin) (RW128) Antibody
Mouse, Rat, Primate, Human
IF, IHC, IHC-P, IP, WB
Biotin Conjugated
0.2 ml/$406
EP300 / p300 Antibody - Anti-EP300 / p300 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EP300 / p300 Mouse anti-Human Monoclonal (aa1572-2371) (DY650) (RW128) Antibody
Mouse, Rat, Primate, Human
IF, IHC, IHC-P, IP, WB
DY650 Conjugated
0.2 ml/$406
EP300 / p300 Antibody - Anti-EP300 / p300 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EP300 / p300 Mouse anti-Human Monoclonal (aa1572-2371) (DY488) (RW128) Antibody
Mouse, Rat, Primate, Human
IF, IHC, IHC-P, IP, WB
DY488 Conjugated
0.2 ml/$406
EP300 / p300 Antibody - Anti-EP300 / p300 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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EP300 / p300 Mouse anti-Human Monoclonal (aa1572-2371) (DY550) (RW128) Antibody
Mouse, Rat, Primate, Human
IF, IHC, IHC-P, IP, WB
DY550 Conjugated
0.2 ml/$406
EP300 / p300 Antibody - Anti-EP300 / p300 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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EP300 / p300 Mouse anti-Human Monoclonal (1D2) Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$545
EP300 / p300 Antibody - Western blot analysis of p300 (AcK1542) expression in Jurkat (A); HeLa (B) whole cell lysates.
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EP300 / p300 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
WB
Unconjugated
30 µl/$253; 100 µl/$305; 200 µl/$369
EP300 / p300 Antibody - Western blot analysis of p300 (pS1834) expression in A549 (A); Raw264.7 (B); PC12 (C) whole cell lysates.
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EP300 / p300 Rabbit anti-Human Polyclonal (pSer1834) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$305
EP300 / p300 Antibody - Detection of Human p300 by Immunohistochemistry. Sample: FFPE section of human lung carcinoma. Antibody: Affinity purified rabbit anti-p300 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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EP300 / p300 Rabbit anti-Human Polyclonal (aa950-1000) Antibody
Human
ChIP-Seq, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$457
EP300 / p300 Antibody - Anti-EP300 / p300 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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EP300 / p300 Mouse anti-Human Monoclonal (aa1572-2371) (RW109) Antibody
Mouse, Rat, Mustelid, Primate, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
0.2 ml/$460
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EP300 / p300 Rabbit anti-Human Polyclonal (pSer1834) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$421
EP300 / p300 Antibody - Western blot of EP300 / p300 antibody.
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EP300 / p300 Rabbit anti-Human Polyclonal (aa1351-1601) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$341; 500 µl/$481; 1 ml/$551
EP300 / p300 Antibody - Anti-EP300 / p300 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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EP300 / p300 Mouse anti-Human Monoclonal (1B1) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$495
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EP300 / p300 Mouse anti-Human Monoclonal Antibody
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$604
EP300 / p300 Antibody - Anti-EP300 / p300 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Cancer
EP300 / p300 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
EP300 / p300 Antibody - Immunohistochemical analysis of p300 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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EP300 / p300 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$311
EP300 / p300 Antibody - Immunohistochemistry of paraffin-embedded human skin tissue at dilution 1:100
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EP300 / p300 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$284; 100 µg/$351
EP300 / p300 Antibody - Immunohistochemical analysis of human-uterus tissue. Anti-p300 at 1:200 (4°C, overnight). Antigen retrieval - Sodium Citrate pH6 (>98°C, 20min). Secondary - 1:200 (room temp, 30min). Negative control - Secondary only
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EP300 / p300 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
Select
EP300 / p300 Rabbit anti-Human Polyclonal (pSer89) Antibody
Human
DB, ELISA, IHC, WB
Unconjugated
200 µl/$614
EP300 / p300 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$571
EP300 / p300 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$821
EP300 / p300 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$861
EP300 / p300 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
EP300 / p300 Protein - Recombinant  E1A Binding Protein P300 By SDS-PAGE
Select
E. coli
His, N-Terminal
33.2 kDa
10 µg/$265; 50 µg/$384; 100 µg/$612; 200 µg/$765; 1 mg/$1,748
EP300 / p300 Antibody - KAT3B/p300 antibody IHC-paraffin: Mouse Intestine Tissue.
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EP300 / p300 Rabbit anti-Human Polyclonal (aa2065-2414) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$397
Viewing 1-25 of 123 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).