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IL-10

interleukin 10

IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Gene Name: interleukin 10
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IL10, CSIF, GVHDS, IL-10, IL10A, Interleukin-10, Interleukin 10, TGIF
Target Sequences: NM_000572 NP_000563.1 P22301

Publications (2)

1
Antibodies to human IL-10 neutralize ebvIL-10-mediated cytokine suppression but have no effect on cmvIL-10 activity. Brodeur ND, Spencer JV. Virus research. 2010 153:265-8. (WB; Human) [Full Text Article] [PubMed:20728483] [PMC:PMC3769974] Related Antibodies: LS-C47137.
2
Skin-Derived Mesenchymal Stem Cells Alleviate Atherosclerosis via Modulating Macrophage Function. Li Q, Sun W, Wang X, Zhang K, Xi W, Gao P. Stem cells translational medicine. 2015 November;4:1294-301. (Mouse) [Full Text Article] [PubMed:26400926] [PMC:PMC4622403] Related Antibodies: LS-B4913.

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Antibodies (175)
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IL-10 Antibody - Anti-IL-10 antibody IHC of mouse small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Cancer
IL-10 Rat anti-Mouse Monoclonal (JES5-2A5) Antibody
Mouse, Goat
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$440
IL-10 Antibody - Anti-IL-10 antibody IHC of human spleen, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IL-10 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
IL-10 Antibody - Western blot of human IL-10 recombinant protein probed with Rat anti-Human Interleukin-10 (RAT ANTI HUMAN INTERLEUKIN-10) followed by F(ab)2 Rabbit anti-Rat IgG:HRP (STAR21B).
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IL-10 Rat anti-Human Monoclonal (JES3-12G8) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
0.5 mg/$502
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IL-10 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, WB
Unconjugated
500 µg/$548; 1 mg/$771
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IL-10 Mouse anti-Bovine Monoclonal (Low Endotoxin) (CC320) Antibody
Bovine
ELISA, Flo
Unconjugated, Low Endotoxin
0.5 mg/$627
IL-10 Antibody
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IL-10 Mouse anti-Human Monoclonal (3C12C12) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$318
IL-10 Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma reacted with IL10 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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IL-10 Rabbit anti-Human Polyclonal (aa27-53) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$376
IL-10 Antibody - Western Blot (non-reducing) of IL-10 antibody
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IL-10 Rat anti-Mouse Monoclonal (15B9-1-2) Antibody
Mouse
ELISA, WB
Unconjugated
500 µg/$297
IL-10 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
IL-10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$809
IL-10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Serum
1 Plate/$841
IL-10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$653
Select
IL-10 Mouse anti-Pig Monoclonal Antibody
Pig
ELISA
Unconjugated
500 µg/$682
IL-10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Hamster
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
IL-10 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
2.344 - 150 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$537
IL-10 Antibody - WB of IL10 antibody. Lane 1: Recombinant Rat IL10 Protein 10ng. Lane 2: Recombinant Rat IL10 Protein 5ng. Lane 3: Recombinant Rat IL10 Protein 2.5ng..
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IL-10 Rabbit anti-Rat Polyclonal (aa19-178) Antibody
Rat
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$397
Select
IL-10 Mouse anti-Human Monoclonal (945A5D11) Antibody
Human
ELISA
Unconjugated
500 µg/$631
Select
IL-10 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
100 Tests/$637
IL-10 Antibody - Western blot of IL-10 antibody.
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IL-10 Rabbit anti-Dog Polyclonal (aa21-181) Antibody
Dog
WB
Unconjugated
100 µl/$302; 200 µl/$345; 500 µl/$489; 1 ml/$561
IL-10 Antibody - Western Blot; Sample: Recombinant IL10, Rat.
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IL-10 Mouse anti-Rat Monoclonal Antibody
Rat
WB
Unconjugated
100 µl/$302; 200 µl/$346; 500 µl/$491; 1 ml/$563
IL-10 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
IL-10 ELISA Kit
Select
Sandwich
96-Well Microplate
Chicken
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$630
IL-10 ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$630
IL-10 Protein - Eukaryotic Interleukin 10 (IL10) by SDS-PAGE
Select
293F Cells
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
20kDa
10 µg/$311; 50 µg/$660; 200 µg/$1,184; 100 µg/$1,032; 1 mg/$2,709
IL-10 Antibody - Immunohistochemistry of paraffin-embedded mouse heart.
Select
IL-10 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
Viewing 1-25 of 406 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).