CBX5 / HP1 Alpha is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
|Gene Name:||chromobox homolog 5|
|Synonyms:||CBX5, Chromobox homolog 5, HP1Hs alpha, HP1Hs-alpha, HP1, HP1 alpha homolog, HP1 alpha, HP1-ALPHA, HP1A, Antigen p25, Chromobox protein homolog 5|
|Target Sequences:||NM_012117 NP_036249.1 P45973|
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