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DPP4 / CD26

dipeptidyl-peptidase 4

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Gene Name: dipeptidyl-peptidase 4
Family/Subfamily: Protease , Serine S9B
Synonyms: DPP4, ADCP-2, ADABP, Dipeptidyl peptidase IV, Dipeptidyl-peptidase 4, DPPIV, ADCP2, T-cell activation antigen CD26, CD26, CD26 antigen, Dipeptidyl peptidase 4, Dipeptidylpeptidase 4, DPP IV, TP103
Target Sequences: NM_001935 NP_001926.2 P27487

Publications (2)

1
Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. Proceedings of the National Academy of Sciences of the United States of America. 2016 113:4482-7. (WB; Rat) [Full Text Article] [PubMed:27044116] [PMC:PMC4843433] Related Antibodies: LS-C122983.
2
Overexpression of CD26/DPPIV in mesothelioma tissue and mesothelioma cell lines. Amatya VJ, Takeshima Y, Kushitani K, Yamada T, Morimoto C, Inai K. Oncology reports. 2011 26:1369-75. (IHC-P; Human) [Full Text Article] [PubMed:21894438] Related Antibodies: LS-A8060.

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Antibodies (213)
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DPP4 / CD26 (307)
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DPP4 / CD26 Antibody - Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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DPP4 / CD26 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
DPP4 / CD26 Antibody - Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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DPP4 / CD26 Rabbit anti-Human Polyclonal (Internal) (PE) Antibody
Human, Monkey
IHC, IHC-P
PE Conjugated
100 µl/$650
DPP4 / CD26 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DPP4 / CD26 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
DPP4 / CD26 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DPP4 / CD26 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
DPP4 / CD26 Antibody - Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
DPP4 / CD26 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
DPP4 / CD26 Antibody - Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
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DPP4 / CD26 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
DPP4 / CD26 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DPP4 / CD26 Rabbit anti-Human Polyclonal (aa663-712) Antibody
Rabbit, Mouse, Rat, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$485
DPP4 / CD26 Antibody - Anti-DPP4 / CD26 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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DPP4 / CD26 Mouse anti-Human Monoclonal (11D7) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$565
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$730
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$654
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DPP4 / CD26 Mouse anti-Human Monoclonal (M-A261) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
25 µg/$266; 0.1 mg/$363; 0.2 mg/$444
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DPP4 / CD26 Mouse anti-Rat Monoclonal Antibody
Rat
IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$891
DPP4 / CD26 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DPP4 / CD26 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DPP4 / CD26 Antibody - DPP4 / CD26 antibody (0.3µg/ml) staining of Rat Lung lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
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DPP4 / CD26 Goat anti-Rat Polyclonal (Internal Region) Antibody
Rat
Peptide-ELISA, WB
Unconjugated
100 µg/$451
DPP4 / CD26 Antibody - Anti-CD26 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
DPP4 / CD26 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
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DPP4 / CD26 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IP
Unconjugated
100 µg/$498
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DPP4 / CD26 Mouse anti-Rat Monoclonal (Biotin) (OX-61) Antibody
Rat
Flo, IHC, IHC-Fr, IP, WB
Biotin Conjugated
100 µg/$315; 500 µg/$451
DPP4 / CD26 Antibody - Western blot analysis of CD26 expression in HEK293T (A); NS-1 (B); PC12 (C) whole cell lysates.
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DPP4 / CD26 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$289
DPP4 / CD26 Antibody
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DPP4 / CD26 Rabbit anti-Human Polyclonal (aa484-728) Antibody
Pig, Human
WB
Unconjugated
100 µl/$289; 200 µl/$327; 500 µl/$454; 1 ml/$517
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DPP4 / CD26 Mouse anti-Human Monoclonal (DPP4/910) Antibody
Rat, Human
Flo, IF, IHC, IHC-Fr
Unconjugated
20 µg/$347; 100 µg/$522
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DPP4 / CD26 Mouse anti-Rat Monoclonal (PE) (OX-61) Antibody
Rat
Flo
PE Conjugated
50 µg/$317; 200 µg/$525
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DPP4 / CD26 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$571
DPP4 / CD26 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$574
DPP4 / CD26 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,646; 100 µg/$565; 20 µg/$395
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DPP4 / CD26 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo, IHC, IHC-Fr, IP
Biotin Conjugated
100 Tests/$644
Viewing 1-25 of 307 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).