ROR1 is a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
|Gene Name:||receptor tyrosine kinase-like orphan receptor 1|
|Family/Subfamily:||Protein Kinase , Trk/Ror|
|Synonyms:||ROR1, DJ537F10.1, NTRKR1, Protein tyrosine kinase t-ror1|
|Target Sequences:||NM_005012 NP_005003.2 Q01973|
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