MYC / c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
|Gene Name:||v-myc avian myelocytomatosis viral oncogene homolog|
|Synonyms:||MYC, BHLHe39, C-Myc, MRTL, Myc proto-oncogene protein, Proto-oncogene c-Myc, Rats1, Transcription factor p64, v-myc|
|Target Sequences:||NM_002467 NP_002458.2 P01106|
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