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MYC / c-Myc

v-myc avian myelocytomatosis viral oncogene homolog

MYC / c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

Gene Name: v-myc avian myelocytomatosis viral oncogene homolog
Synonyms: MYC, BHLHe39, C-Myc, MRTL, Myc proto-oncogene protein, Proto-oncogene c-Myc, Rats1, Transcription factor p64, v-myc
Target Sequences: NM_002467 NP_002458.2 P01106

Publications (25)

1
Characterization of monoclonal antibodies reactive to several biochemically distinct human cytomegalovirus glycoprotein complexes. Kari B, Lussenhop N, Goertz R, Wabuke-Bunoti M, Radeke R, Gehrz R. Journal of virology. 1986 60:345-52. [PubMed:3021969] [PMC:PMC288899]
2
The ornithine decarboxylase gene is a transcriptional target of c-Myc. Bello-Fernandez C, Packham G, Cleveland JL. Proceedings of the National Academy of Sciences of the United States of America. 1993 90:7804-8. [PubMed:8356088] [PMC:PMC47231]
3
Association of the class V myosin Myo4p with a localised messenger RNA in budding yeast depends on She proteins. Mnchow S, Sauter C, Jansen RP. Journal of cell science. 1999 1511-8. (IP; Yeast) [PubMed:10212145]
4
Oncogenes and male breast carcinoma: c-erbB-2 and p53 coexpression predicts a poor survival. Pich A, Margaria E, Chiusa L. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2000 18:2948-56. (IHC-P; Human) [PubMed:10944127]
5
Anti-c-myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose. Hilpert K, Hansen G, Wessner H, Kttner G, Welfle K, Seifert M, Hhne W. Protein engineering. 2001 14:803-6. [PubMed:11739900]
6
Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Tanaka S, Diffley JF. Nature cell biology. 2002 4:198-207. (IP; Bacteria) [PubMed:11836525]
7
The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Zhang H, Richardson DO, Roberts DN, Utley R, Erdjument-Bromage H, Tempst P, Ct J, Cairns BR. Molecular and cellular biology. 2004 24:9424-36. [PubMed:15485911] [PMC:PMC522225]
8
Global position and recruitment of HATs and HDACs in the yeast genome. Robert F, Pokholok DK, Hannett NM, Rinaldi NJ, Chandy M, Rolfe A, Workman JL, Gifford DK, Young RA. Molecular cell. 2004 16:199-209. [PubMed:15494307] [PMC:PMC3004369]
9
Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation. Sanders JA, Gruppuso PA. Biochimica et biophysica acta. 2005 1743:141-50. [PubMed:15777849]
10
Activation of the Kaposi's sarcoma-associated herpesvirus major latency locus by the lytic switch protein RTA (ORF50). Matsumura S, Fujita Y, Gomez E, Tanese N, Wilson AC. Journal of virology. 2005 79:8493-505. [PubMed:15956592] [PMC:PMC1143749]
11
Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH. American journal of physiology. Heart and circulatory physiology. 2007 292:H1847-60. [PubMed:17158653]
12
Visualization of intracellular PP1 targeting through transiently and stably expressed fluorescent protein fusions. Trinkle-Mulcahy L, Chusainow J, Lam YW, Swift S, Lamond A. Methods in molecular biology (Clifton, N.J.). 2007 365:133-54. [PubMed:17200560]
13
Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Silvestri L, Pagani A, Camaschella C. Blood. 2008 111:924-31. [PubMed:17938254]
14
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Huynh H, Ngo VC, Fargnoli J, Ayers M, Soo KC, Koong HN, Thng CH, Ong HS, Chung A, Chow P, Pollock P, Byron S, Tran E. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 14:6146-53. (WB) [PubMed:18829493]
15
Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX. Murri-Plesko MT, Hulikova A, Oosterwijk E, Scott AM, Zortea A, Harris AL, Ritter G, Old L, Bauer S, Swietach P, Renner C. European journal of pharmacology. 2011 657:173-83. [PubMed:21315712]
16
MCM proteins are negative regulators of hypoxia-inducible factor 1. Hubbi ME, Luo W, Baek JH, Semenza GL. Molecular cell. 2011 42:700-12. (WB, IP; Human) [PubMed:21658608] [PMC:PMC3131976]
17
The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase. Kim MY, Jung J, Mo JS, Ann EJ, Ahn JS, Yoon JH, Park HS. Experimental cell research. 2011 317:2438-46. [PubMed:21820430]
18
Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines. Kondo S, Wakisaka N, Muramatsu M, Zen Y, Endo K, Murono S, Sugimoto H, Yamaoka S, Pagano JS, Yoshizaki T. Journal of virology. 2011 85:11255-64. (WB; Human) [PubMed:21849440] [PMC:PMC3194961] Related Antibodies: LS-B3910.
19
CutA divalent cation tolerance homolog (Escherichia coli) (CUTA) regulates -cleavage of -amyloid precursor protein (APP) through interacting with -site APP cleaving protein 1 (BACE1). Zhao Y, Wang Y, Hu J, Zhang X, Zhang YW. The Journal of biological chemistry. 2012 287:11141-50. (WB; Human) [PubMed:22351782] [PMC:PMC3322838]
20
Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential. Decarpentrie F, Vernet N, Mahadevaiah SK, Longepied G, Streichemberger E, Aknin-Seifer I, Ojarikre OA, Burgoyne PS, Metzler-Guillemain C, Mitchell MJ. Human molecular genetics. 2012 21:2631-45. [PubMed:22407129] [PMC:PMC3363334] Related Antibodies: LS-B3910.
21
Autoregulation of MARCH1 expression by dimerization and autoubiquitination. Bourgeois-Daigneault MC, Thibodeau J. Journal of immunology (Baltimore, Md. : 1950). 2012 188:4959-70. [PubMed:22508929] Related Antibodies: LS-B3910.
22
CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks. Wang H, Shao Z, Shi LZ, Hwang PY, Truong LN, Berns MW, Chen DJ, Wu X. The Journal of biological chemistry. 2012 287:21471-80. (WB, IP; Human) [PubMed:22544744] [PMC:PMC3375568]
23
Staphylococcus aureus adherence to Candida albicans hyphae is mediated by the hyphal adhesin Als3p. Peters BM, Ovchinnikova ES, Krom BP, Schlecht LM, Zhou H, Hoyer LL, Busscher HJ, van der Mei HC, Jabra-Rizk MA, Shirtliff ME. Microbiology (Reading, England). 2012 158:2975-86. [PubMed:22918893] Related Antibodies: LS-B3910.
24
The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. Lu CS, Truong LN, Aslanian A, Shi LZ, Li Y, Hwang PY, Koh KH, Hunter T, Yates JR, Berns MW, Wu X. The Journal of biological chemistry. 2012 287:43984-94. (WB, IP; Human) [PubMed:23115235] [PMC:PMC3527981]
25
Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair. Robu M, Shah RG, Petitclerc N, Brind'Amour J, Kandan-Kulangara F, Shah GM. Proceedings of the National Academy of Sciences of the United States of America. 2013 110:1658-63. [PubMed:23319653] [PMC:PMC3562836] Related Antibodies: LS-B3910.
more

☰ Filters
Antibodies (338)
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1788CT320.61.28 (1)
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MYC / c-Myc Antibody - Anti-MYC / c-Myc antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer Pathology
Cancer
MYC / c-Myc Mouse anti-Human Monoclonal (aa408-439) (9E10) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$440
MYC / c-Myc Antibody - Anti-MYC / c-Myc antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer Pathology
Cancer
MYC / c-Myc Mouse anti-Human Monoclonal (aa400-450) (9E10) Antibody
All species, Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
Select
MYC / c-Myc Mouse anti-Human Monoclonal (aa423-435) (FITC) (9E10) Antibody
All species, Human
Flo, IHC-P, IP, WB
FITC Conjugated
0.1 mg/$358
MYC / c-Myc Antibody - Anti-MYC / c-Myc antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
MYC / c-Myc Rabbit anti-Human Polyclonal (aa 398-439) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$505
MYC / c-Myc Antibody - IHC of paraffin-embedded Human breast tissue using anti-MYC mouse monoclonal antibody.
Select
MYC / c-Myc Mouse anti-Human Monoclonal (OTI5G3) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
MYC / c-Myc Antibody - c-Myc Antibody (9E10) - Western blot of c-myc in Jurkat cell lysates.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
MYC / c-Myc Mouse anti-Human Monoclonal (9E10) Antibody
Mouse, Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
0.1 ml/$376
MYC / c-Myc Antibody - Western Blot: c-Myc Antibody (9E10) [Biotin] - Analysis of c-myc in Jurkat cell lysates. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
MYC / c-Myc Mouse anti-Human Monoclonal (Biotin) (9E10) Antibody
Drosophila, Mouse, Human
ELISA, Flo, ICC, IF, IHC, IHC-Fr, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$406
Select
MYC / c-Myc Chicken Polyclonal (Biotin) Antibody
ELISA, WB
Biotin Conjugated
100 µg/$514
MYC / c-Myc ELISA Kit
Select
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$774
MYC / c-Myc ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$792
MYC / c-Myc ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
MYC / c-Myc ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$654
Select
E. coli
6His, N-terminus
52.8 kDa
1 mg/$1,152; 10 µg/$282; 100 µg/$400
MYC / c-Myc Protein - Active V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) by WB
Select
E. coli
His-GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
65kDa
10 µg/$329; 50 µg/$765; 200 µg/$1,306; 100 µg/$1,129; 1 mg/$3,073
MYC / c-Myc Protein
Select
E. coli
6His, N-terminus
51 kDa
10 µg/$255; 50 µg/$305; 100 µg/$355
MYC / c-Myc Antibody - Anti-MYC / c-Myc antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Cancer Pathology
Cancer
MYC / c-Myc Rabbit anti-Human Polyclonal (aa25-74) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$460
Select
MYC / c-Myc Sheep anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
500 µg/$369
MYC / c-Myc Antibody - Immunohistochemical analysis of c-Myc staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
MYC / c-Myc Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$289
MYC / c-Myc Antibody - MYC / c-Myc antibody Western blot of HT1080 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
MYC / c-Myc Rabbit anti-Human Polyclonal (aa35-84) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Rat, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
100 µl/$434
MYC / c-Myc Protein
Select
E. coli
GST, N-terminus
53 kD
1 mg/$1,646; 100 µg/$490; 20 µg/$354
MYC / c-Myc Antibody - Immunohistochemical analysis of c-Myc (pT58) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
MYC / c-Myc Rabbit anti-Human Polyclonal (pThr58) Antibody
Chicken, Zebrafish, Pig, Mouse, Dog, Sheep, Bovine, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$305
MYC / c-Myc Antibody - IHC of p-Myc (T58) pAb in paraffin-embedded human breast carcinoma tissue.
Select
MYC / c-Myc Rabbit anti-Human Polyclonal (pThr58) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$327; 100 µl/$409
MYC / c-Myc Antibody - Anti-MYC mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MYC.
Select
MYC / c-Myc Mouse anti-Human Monoclonal (OTI5E9G2) Antibody
Dog, Rat, Human, Monkey
IF, WB
Unconjugated
100 µl/$409
Select
MYC / c-Myc Mouse anti-Human Monoclonal (Biotin) (9E10) Antibody
All species, Human
Flo, IHC-P, IP, WB
Biotin Conjugated
0.1 mg/$358
MYC / c-Myc Antibody - MYC / c-Myc antibody MYC(myc protein) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
MYC / c-Myc Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Guinea pig, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Viewing 1-25 of 395 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).