This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.
|Gene Name:||CD55 molecule, decay accelerating factor for complement (Cromer blood group)|
|Synonyms:||CD55, CD55 antigen, Decay-accelerating factor, TC, CR, CROM, DAF|
|Target Sequences:||NM_000574 NP_000565.1 P08174|
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