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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TS / Thymidylate Synthase

thymidylate synthetase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Gene Name: thymidylate synthetase
Synonyms: TYMS, HST422, Thymidylate synthetase, TMS, TS, Thymidylate synthase, Tsase
Target Sequences: NM_001071 NP_001062.1 P04818

Publications (1)

1
Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. Haqqani AS, Cowling RT, Maroun JA, Birnboim HC. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1999 47:1563-74. [PubMed:10567440]


TS / Thymidylate Synthase Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone 3F1] (IgG2a) to Human TS / Thymidylate Synthase
Human
IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
TS / Thymidylate Synthase Antibody - Anti-TYMS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 2B2] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   $495.00
TS / Thymidylate Synthase Antibody - Anti-TYMS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Sheep Polyclonal to Human TS / Thymidylate Synthase
Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50µl   10mg/ml   $425.00
TS / Thymidylate Synthase Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone 10F12] (IgG2a) to Human TS / Thymidylate Synthase
Human
IHC, IHC-P, WB
Unconjugated
100µl   $425.00
TS / Thymidylate Synthase Antibody - Anti-TYMS/TS/Thymidylate Synthase antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Sheep Polyclonal to Human TS / Thymidylate Synthase
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.5ml   $485.00
TS / Thymidylate Synthase Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone OTI2C3] (IgG2a) to Human TS / Thymidylate Synthase
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
Select
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg   $635.00
TS / Thymidylate Synthase Antibody - Detection of Human and Mouse TS by Western Blot. Samples: Whole cell lysate (50 ug) from Jurkat, 293T, HeLa, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-TS antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Select
Rabbit Polyclonal (IgG) to Human TS / Thymidylate Synthase
Mouse, Human
IHC, IP, WB
Unconjugated
100µl   1mg/ml   $405.00
TS / Thymidylate Synthase Antibody - TYSY Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Rabbit Polyclonal to Human TS / Thymidylate Synthase
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µg   $635.00
Select
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IP, WB
HRP Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IP, WB
Biotin Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IP, WB
FITC Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IP, WB
PE Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IP, WB
APC Conjugated
100µl   $815.00
Select
Mouse Monoclonal (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
500µl   $665.00
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715).
Select
Mouse Monoclonal [clone TMS715] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20µg   0.2mg/ml   $295.00; 100µg   0.2mg/ml   $465.00
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715). This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone TMS715] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Ready-to-Use
7ml   $465.00
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715). This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone TMS715] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free
100µg   1mg/ml   $465.00
Select
Mouse Monoclonal to Human TS / Thymidylate Synthase
Human
ELISA, Flo, ICC, IF, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $345.00
Select
Mouse Monoclonal [clone TS 106] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IP, WB
Unconjugated
0.1ml   $280.00; 0.5ml   $555.00; 1ml   $880.00
Select
Mouse Monoclonal [clone TS 106] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IP, WB
Unconjugated, Azide-free
0.1ml   $620.00; 0.2ml   $945.00
Select
Mouse Monoclonal [clone TS106] (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA, Flo, IF, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1mg   $875.00
TS / Thymidylate Synthase Antibody - Western blot analysis of extracts of various cell lines, using TYMS antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Select
Rabbit Polyclonal (IgG) to Human TS / Thymidylate Synthase
Human
Flo, IF, IHC, WB
Unconjugated
100µl   $295.00; 200µl   $385.00
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TS106).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone TS106] (IgG1,k) to Human TS / Thymidylate Synthase
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free
100µg   1mg/ml   $465.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).