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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TS / Thymidylate Synthase

thymidylate synthetase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Gene Name: thymidylate synthetase
Synonyms: TYMS, HST422, Thymidylate synthetase, TMS, TS, Thymidylate synthase, Tsase
Target Sequences: NM_001071 NP_001062.1 P04818

Publications (1)

1
Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. Haqqani AS, Cowling RT, Maroun JA, Birnboim HC. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1999 47:1563-74. [PubMed:10567440]

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TS / Thymidylate Synthase Antibody - Anti-TYMS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (2B2) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$495
TS / Thymidylate Synthase Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (3F1) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$425
TS / Thymidylate Synthase Antibody - Anti-TYMS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TS / Thymidylate Synthase Sheep anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$425
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$635
TS / Thymidylate Synthase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$790
TS / Thymidylate Synthase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$510
TS / Thymidylate Synthase Protein - Recombinant  Thymidylate Synthetase By SDS-PAGE
Select
E. coli
His-S
35.6 kDa
10 µg/$275; 50 µg/$445; 100 µg/$590; 200 µg/$860; 1 mg/$2,205
TS / Thymidylate Synthase Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (OTI2C3) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$425
TS / Thymidylate Synthase Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (10F12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$425
TS / Thymidylate Synthase Antibody - Detection of Human and Mouse TS by Western Blot. Samples: Whole cell lysate (50 ug) from Jurkat, 293T, HeLa, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-TS antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
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TS / Thymidylate Synthase Rabbit anti-Human Polyclonal (aa263-313) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
100 µl/$405
TS / Thymidylate Synthase Antibody - TYSY Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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TS / Thymidylate Synthase Rabbit anti-Human Polyclonal (aa265-294) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$325
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
500 µl/$665
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$635
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
HRP Conjugated
100 µl/$815
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Biotin Conjugated
100 µl/$815
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
FITC Conjugated
100 µl/$815
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
APC Conjugated
100 µl/$815
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
PE Conjugated
100 µl/$815
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715).
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (TMS715) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$295; 100 µg/$465
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715). This image was taken for the unmodified form of this product. Other forms have not been tested.
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Ready-to-Use) (TMS715) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Ready-to-Use
7 ml/$465
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715). This image was taken for the unmodified form of this product. Other forms have not been tested.
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Azide-free) (TMS715) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free
100 µg/$465
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IF, WB
Unconjugated
50 µl/$315; 100 µl/$345
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TS106).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Azide-free) (TS106) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free
100 µg/$465
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TS106).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Ready-to-Use) (TS106) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$465
TS / Thymidylate Synthase Antibody - Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TS106 + TMS715).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
TS / Thymidylate Synthase Mouse anti-Human Monoclonal (Ready-to-Use) (TS106 + TMS715) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$465
Viewing 1-25 of 137 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).