TANK2 / TNKS2

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.

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Products

Proteins (2)

Type

Recombinant (2)

Target

TANK2 / TNKS2 (2)

Publications

No (2)

Tag

GST, N-terminus (1)

His-T7, N-terminus (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human TANK2 / TNKS2 Protein (Recombinant GST, N-terminus) (aa1068-1166) - LS-G63250

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TANK2 / TNKS2 Protein (Recombinant His-T7, N-terminus) (Ser959-Gly1166) - LS-G132584

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

27.4kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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